Stress and obesity can lead to high blood pressure and greatly increase the risk of life threatening cardiovascular events. This application seeks to determine which chemicals and parts of the brain are responsible for amplifying the responses to repeated stress and during obesity in animal models leading to hypertension.
MEDICINAL CHEMISTRY LED DISCOVERY OF NEW TREATMENTS FOR HUMAN AFRICAN TRYPANOSOMIASIS AND BETA-THALASSEMIA
Funder
National Health and Medical Research Council
Funding Amount
$636,524.00
Summary
I am a medicinal chemist interested in finding new treatments for sleeping sickness, a parasitic disease, and the blood diseases sickle cell anaemia and beta-thalassemia. After testing more than 80,000 compounds, we have discovered some promising starting points for drug discovery. These so-called “screening hits” are too weak to be useful but I hope to use my medicinal chemistry expertise to make these more potent, more selective, and hence therapeutically useful.
Affordable And Scaleable New Strategies For Cardiovascular Disease Control
Funder
National Health and Medical Research Council
Funding Amount
$609,384.00
Summary
This Fellowship will support Professor Anthony Rodgers to continue a track record of excellence in health research, public-private partnerships and innovation. He has led landmark cardiovascular trials and was Principal Author of the WHO World Health Report. He plans a program of research on new combination cardiovascular medicines ('polypills'). Polypill trials that Professor Rodgers initiated have recently shown improved clinical outcomes, patient acceptability, quality of life and cost saving ....This Fellowship will support Professor Anthony Rodgers to continue a track record of excellence in health research, public-private partnerships and innovation. He has led landmark cardiovascular trials and was Principal Author of the WHO World Health Report. He plans a program of research on new combination cardiovascular medicines ('polypills'). Polypill trials that Professor Rodgers initiated have recently shown improved clinical outcomes, patient acceptability, quality of life and cost savings.Read moreRead less
Clinical And Public Health Interventions For Preventing Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$137,595.00
Summary
Professor Neal’s research has two main components – the first will identify new drug therapies for the management of diabetes and the second will provide new evidence about ways to improve the healthiness of the food supply in Australia.
I am a cardiologist with a research focus on discovering and evaluating new treatments and novel clinical strategies for implementing evidence-based cardiovascular disease prevention into routine clinical practice.
Molecular Regulation Of Haematopoiesis In Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$863,413.00
Summary
The blood forming system coordinates production of cells that confer immunity to infection, transport oxygen and assist blood clotting. When the molecular mechanisms that control these functions go awry, diseases including leukaemia and autoimmunity result. This research will define fundamental molecular regulators of blood cell production and function, assess their role in blood cell diseases and explore their potential to provide leads for development of new therapeutics.
Developing And Implementing Proven Treatments And Systems Of Care In Stroke
Funder
National Health and Medical Research Council
Funding Amount
$873,684.00
Summary
This fellowship will allow me to continue undertaking large-scale, multicentre, national and international, randomised controlled trials and population-based epidemiological studies focussed on the prevention and managment of acute stroke and other aspects of cardiovascular disease related to ageing populations. Much of my research is focussed on research and health policy of populations in Asia, particularly China, where i have had a sustained program of collaborative research over 10 years.
My research projects in the fields of cancer biology, vascular biology and immunology assess molecular mechanisms of vascular remodelling and implications for disease.
Targeting Prevention And Treatment Of Hypertensive Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$774,540.00
Summary
Hypertension, high blood pressure, is a major global health burden. It contributes to heart disease, stroke and kidney failure, and as such is a major cause of premature death worldwide. Advances in the treatment of hypertension has meant that more people are living with disabilities associated with cardiovascular disease. Our work focuses on identifying new treatments to prevent the devastating effects of hypertension on organ function to improve quality of life in men and women.