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Research Topic : blood pressure regulation
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  • Funded Activity

    Developing A National Salt Reduction Program For India

    Funder
    National Health and Medical Research Council
    Funding Amount
    $935,028.00
    Summary
    Excess dietary salt is a leading cause of premature strokes and heart attacks around the world. India, the world’s second most populous nation has no coordinated national salt reduction program and lacks key data upon which to formulate a strategy. This research will bring together Australian experts in the field with leading Indian researchers to make the baseline assessments required to formulate and commence population-wide salt reduction efforts in India.
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    Funded Activity

    Randomised Controlled Trial Of Early Use Of A Simplified Treatment Regimen Incorporating A Half-dose, Three-in-one Blood Pressure Lowering Pill Vs. Usual Care For Improving Hypertension Control In India.

    Funder
    National Health and Medical Research Council
    Funding Amount
    $1,095,201.00
    Summary
    Hypertension affects a large proportion of the Indian population. Effective medications exist to lower blood pressure (BP) and the adverse effects of hypertension. However, complex medication regimes and the need to take multiple drugs can affect patient adherence to drugs, making it difficult to achieve good BP control. This research will investigate whether use of a simplified treatment protocol including a three-in-one BP lowering pill can improve BP control in Indians with hypertension.
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    Funded Activity

    Establishing A Blood-based Biomarker Panel For Pre-clinical Alzheimer’s Disease

    Funder
    National Health and Medical Research Council
    Funding Amount
    $716,778.00
    Summary
    The current gold standard biomarkers for Alzheimer’s disease (AD) are uneconomical and invasive, thus impeding early treatment prior to irreversible damage. I posit that biochemical changes associated with the disease are reflected in the blood several years prior to the clinical manifestation of the disease. Therefore, I propose to investigate these changes in individuals predisposed to AD, prior to the appearance of clinical symptoms, to identify biomarkers for the early diagnosis of AD.
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    Vasoactive Nutrients To Promote Healthy Ageing In Postmenopausal Women

    Funder
    National Health and Medical Research Council
    Funding Amount
    $598,031.00
    Summary
    Poor circulatory function in the brain, associated with mood and cognitive disturbances, can be further exacerbated by ageing and estrogen deprivation at postmenopause. My research will determine whether phytoestrogen supplementation with either resveratrol or genistein for 2 years can counteract menopause-related impairments in mood and mental performance by enhancing cerebral vasodilator function and whether the magnitude of improvement differs between early and late menopausal years.
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    Funded Activity

    Novel Targeted Degradable Multifunctional Poly(vinyl-co-ester) Nanoparticles For Alzheimer’s Disease Applications

    Funder
    National Health and Medical Research Council
    Funding Amount
    $601,940.00
    Summary
    Novel biodegradable polymeric nanoparticles for efficient and targeted delivery of Alzheimer related agents to the brain will be developed. The nanocarriers will be fabricated from biocompatible multifunctional compounds and possess the capability to co-deliver diagnostic and therapeutic agents across the blood-brain barrier. These systems are expected to become a new efficient class of brain delivery systems.
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    Funded Activity

    Pericyte Dysfunction Limiting Energy Supply In Alzheimer's Disease

    Funder
    National Health and Medical Research Council
    Funding Amount
    $717,708.00
    Summary
    One possible cause of Alzheimer’s disease (AD) could be narrowing of small blood vessels (capillaries) within the brain, limiting blood flow and energy supply. Pericytes, a cell only on capillaries, maintain blood flow throughout the brain. I believe that pericytes may die in AD leading to an energy deficit and memory problems. I will test using human brains and animal models whether pericyte loss causes AD and how this is happening. Pericytes could provide a new therapy option for AD.
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    Funded Activity

    Dementia Associated To Diabetes: Prevention Through The Modulation Of Cerebrovascular Integrity

    Funder
    National Health and Medical Research Council
    Funding Amount
    $719,770.00
    Summary
    Diabetic insulin resistance is reported to induce cognitive decline and dementia. An accumulating body of evidence suggest that compromised integrity of neurovascular unit and following changes in cerebral lipid homeostasis may be centrally involved in the neurodegeneration and cognitive deficits. Therefore, the project aims to prevent the insulin resistance-associated cognitive impairment by modulating the integrity of cerebrovasculature and lipid homeostasis.
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    Showing 1-7 of 7 Funded Activites

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