Characterisation Of Human Embryonic Stem Cell Differentiation To Haematopoietic Progenitors And Stem Cells
Funder
National Health and Medical Research Council
Funding Amount
$638,856.00
Summary
Blood stem cells, which are found in the bone marrow, are currently used for treating human blood disorders including leukemia and lymphoma. However, for the majority of bone marrow transplant candidates, suitable donors cannot be found. Using embryonic stem cells, this project aims to define the conditions required to generate blood stem cells in the laboratory. The aim of the work is to provide a new source of blood stem cells that could be used in place of donor derived bone marrow.
Simulating And Stimulating The Blood-Brain-Barrier: A Platform For Investigating Non-pharmaceutical Alzheimer's Therapy
Funder
National Health and Medical Research Council
Funding Amount
$680,758.00
Summary
Alzheimer's disease is a looming public health threat worldwide. Despite the widespread acknowledgement of this issue, there are a lack of effective drugs that can slow disease progression. This project aims to investigate a new class of non-pharmaceutical treatment methods based on controlled acoustic, electrical and optical stimulation methods to treat and reverse the base causes of Alzheimer's disease.
Representation Theory: Path models and decompositions. The research in this proposal develops tools for capitalising on the benefits of symmetry in large complex systems. These techniques and processes are applicable for solving complex problems in large interactive systems. This project will involve young researchers and train them for problem solving in a wealth of fields, including management, the sciences, the financial industries, and the development of technologies. The research is in o ....Representation Theory: Path models and decompositions. The research in this proposal develops tools for capitalising on the benefits of symmetry in large complex systems. These techniques and processes are applicable for solving complex problems in large interactive systems. This project will involve young researchers and train them for problem solving in a wealth of fields, including management, the sciences, the financial industries, and the development of technologies. The research is in one of the most active cutting edge areas of pure mathematics and will contribute to maintaining Australia's position as a leading nationality in research in representation theory and its applications.
Read moreRead less
Modelling Of Clinic And Ambulatory Blood Pressure On Cardiovascular Risk And Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$133,957.00
Summary
Whilst ambulatory blood pressure monitoring data has been shown to be a good predictor of cardiovascular events, there remains controversy as to its utility in clinical practice. This project will use data from existing population and clinical cohort studies to examine the role of ambulatory blood pressure in risk assessment and hypertension management in Australia and around the globe. The findings are likely to have a major impact on clinical guidelines for hypertension management.
Understanding The Origins Of Neurogenic Hypertension
Funder
National Health and Medical Research Council
Funding Amount
$668,914.00
Summary
Brain cells that control the cardiovascular system are thought to have stopped dividing by adulthood. We recently discovered that this is not the case. Our initial findings suggest that these nascent cells might be important for maintaining normal blood pressure. This work will allow us to elucidate the function of these nascent cells and how they integrate into the circuit that controls the cardiovascular system. Our findings will be fundamental for understanding diseases such as hypertension.
Assessing risk in aged mental health care. This study will explore practices and developments in relation to the assessment of risk in aged persons mental health from the perspective of multiple stakeholders. The aims are to gain a thorough understanding of existing practices with a view to developing and evaluating a comprehensive risk assessment model. The outcomes will enhance the provision of mental health services within aged mental health services.
Global wavefront propagation and non-elliptic Fredholm theory. Many significant phenomena in the natural world are described by partial differential equations that involve evolution in time. This project aims to develop new mathematical methods, involving recently discovered global wavefront set analysis and Fredholm theory, to solve such equations. These methods aim to extend the range of equations that can be solved as well as yield more information about solutions, in particular, their long-t ....Global wavefront propagation and non-elliptic Fredholm theory. Many significant phenomena in the natural world are described by partial differential equations that involve evolution in time. This project aims to develop new mathematical methods, involving recently discovered global wavefront set analysis and Fredholm theory, to solve such equations. These methods aim to extend the range of equations that can be solved as well as yield more information about solutions, in particular, their long-time asymptotics.Read moreRead less
Harmonic analysis and dispersive partial differential equations. This project aims to develop theoretical results and practical techniques in the study of Partial Differential Equations. Harmonic analysis is used to study these equations; in which a system’s local behaviour is used to analyse global properties, using techniques such as the Fourier transform. The project will investigate central problems in the area, revealing deep connections between analysis and geometry, and apply these to stu ....Harmonic analysis and dispersive partial differential equations. This project aims to develop theoretical results and practical techniques in the study of Partial Differential Equations. Harmonic analysis is used to study these equations; in which a system’s local behaviour is used to analyse global properties, using techniques such as the Fourier transform. The project will investigate central problems in the area, revealing deep connections between analysis and geometry, and apply these to study the solutions’ long-term behaviour to non-linear equations. Expected outcomes include theoretical results and practical techniques to solve non-linear dispersive equations, which arise in quantum and fluid mechanics.Read moreRead less
Diverse Teams and Health Care - Problem or Cure? Research that is able to improve the quality of work life and patient care of health care professionals is vital to communities around Australia where work pressures placed on healthcare professionals are at an all time high as are shortages of qualified personnel. The research team brings together leading edge researchers in healthcare management, diversity, teamwork and workplace management. The project will result in a comprehensive descripti ....Diverse Teams and Health Care - Problem or Cure? Research that is able to improve the quality of work life and patient care of health care professionals is vital to communities around Australia where work pressures placed on healthcare professionals are at an all time high as are shortages of qualified personnel. The research team brings together leading edge researchers in healthcare management, diversity, teamwork and workplace management. The project will result in a comprehensive description of the types of diverse teams working in hospitals, policy and practice and will make recommendations for diversity management in the healthcare system, and the development of new international research collaborations in hospital research and development.Read moreRead less
Partial differential equation: Schrodinger operator and long-time dynamics. This project aims to develop new analysis methods associated to the Schrodinger operator, and to solve several challenging problems regarding dispersive partial differential equations (PDE). Long-time dynamics of PDE solutions are a key goal in both pure and applied mathematics, and have been extensively studied by leading mathematicians and mathematical physicists. However, it is unknown how to investigate large soluti .... Partial differential equation: Schrodinger operator and long-time dynamics. This project aims to develop new analysis methods associated to the Schrodinger operator, and to solve several challenging problems regarding dispersive partial differential equations (PDE). Long-time dynamics of PDE solutions are a key goal in both pure and applied mathematics, and have been extensively studied by leading mathematicians and mathematical physicists. However, it is unknown how to investigate large solutions when the order of the PDE's nonlinearity is low. This project expects to develop new methods to attack such problems. The results of the project will be of great importance in mathematics and physics, as many fundamental physical models in areas such as optics, fluid mechanics and quantum mechanics fit the paradigm.Read moreRead less