Elucidating Metabolic Dysregulation In Alzheimer’s Disease: Profiling The Peripheral Immune Cell Lipidome To Unravel Pathological Mechanisms.
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Both the immune system and lipid metabolism have been identified to be important in Alzheimer’s disease (AD). With the failures of all clinical trials attempting to treat AD, we seek to determine a way to both better diagnose individuals with AD and to identify people at increased risk. This project uses a novel profiling technique to characterise the lipid composition of immune cells to diagnose, predict risk, monitor the disease and to identify potential disease modifying therapeutic targets.
Defining how molecular switches program cell identity during development. Aims: This project aims to investigate how molecular switches known as transcription factors, work together to turn genes on or off to program cell identity during development.
Significance: This project expects to generate new knowledge in the area of genetics and developmental biology using collaborative, cutting edge technologies.
Outcomes: Expected outcomes of this project include the identification of new genes impor ....Defining how molecular switches program cell identity during development. Aims: This project aims to investigate how molecular switches known as transcription factors, work together to turn genes on or off to program cell identity during development.
Significance: This project expects to generate new knowledge in the area of genetics and developmental biology using collaborative, cutting edge technologies.
Outcomes: Expected outcomes of this project include the identification of new genes important for programming the identity of cells that comprise our blood vessels, lymphatic vessels and circulating blood cells.
Benefits: Data generated will underpin the development of approaches to program/reprogram stem cells to produce mature cells for transplantation or tissue engineering purposes ex vivo.Read moreRead less
Faecal Microbiota Transplantation And Other Novel Therapeutic Microbial Manipulation Strategies In Inflammatory Bowel Disease
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
There is growing interest in the role of microbial-based strategies including faecal microbiota transplantation (FMT) for the treatment of inflammatory bowel disease. This project will develop such strategies into valid treatment options through a combination of clinical & basic science work including (1) characterising viral & fungal factors of importance, (2) evaluation of novel orally-delivered formulations of FMT, and (3) development of better defined, more reproducible microbial treatments.
Exploring The Occurrence And Potential Associated Risk Factors For Pilchard Orthomyxovirus (POMV) In Tasmanian Farmed Atlantic Salmon
Funder
Fisheries Research and Development Corporation
Funding Amount
$209,295.62
Summary
Following basic epidemiology principles, no infectious disease occurs ‘randomly’ and its occurrence follow logical and predictable patterns. The presence of an infectious agent is unlikely sufficient to explain these patterns and most aquatic diseases result from the complex interaction between the agent, the host and its environment. Therefore, the targeted outcome for a POMV control plan is threefold: 1. Decrease transmission between infected and susceptible fish groups – this requires ide ....Following basic epidemiology principles, no infectious disease occurs ‘randomly’ and its occurrence follow logical and predictable patterns. The presence of an infectious agent is unlikely sufficient to explain these patterns and most aquatic diseases result from the complex interaction between the agent, the host and its environment. Therefore, the targeted outcome for a POMV control plan is threefold: 1. Decrease transmission between infected and susceptible fish groups – this requires identifying risk factors associated with the introduction, spread, and maintenance of the pathogen within the industry; 2. Decrease the number of susceptible fish – this mainly requires identifying risk factors associated with the susceptibility of the host (e.g. husbandry-related stress) and the development of a safe and effective prophylaxis; 3. Decrease the amount of virus in the environment - this requires detecting infected fish cage(s) early to implement timely control strategies. Diagnostic capacity to confirmed POMV outbreak has been developed and is currently used in routine by the industry. A vaccine against POMV is currently under development at the Tasmanian Aquatic Animal Health and Vaccines Centre of Excellence and will be available in the future. However, little is known about risk factors specific to POMV and about its full economic impact. We define as a ‘risk factor’ any attribute of the agent, the host or its environment that increases the risk and intensity of a disease outbreak. Most of the environmental risk factors (including farming practices) facilitate the introduction, transmission, or maintenance of the pathogen; while the host risk factors affect the susceptibility of the host and its capacity to become diseased. Like the closely related ISAv, the magnitude and occurrence of POMV outbreaks appeared to be highly variable. This supports the existence of additional factors other than the POMV infection that contribute to the intensity of an outbreak. It is anticipated that by identifying and intervening on some of the manageable risk factors, the frequency and the severity of POMV outbreaks can be reduced. Objectives: 1. Describe the occurrence of POMV outbreaks in the Tasmanian salmon industry 2. Quantify the direct financial impact of POMV mortality to the Tasmanian salmon industry 3. Identify potential management, environmental and stock risk factors directly or indirectly increasing the risk and intensity of a POMV outbreaks Read moreRead less
Improved cryopreservation protocols for long term storage of platelets. The aim of this project is to characterise human blood platelet deterioration during cold storage and cryopreservation, and accelerate the development of improved long-term storage options. The project expects to generate important new knowledge about how platelets deteriorate during storage, and how such deterioration can be minimized. The expected outcomes are improved methods for long term platelet storage. This should be ....Improved cryopreservation protocols for long term storage of platelets. The aim of this project is to characterise human blood platelet deterioration during cold storage and cryopreservation, and accelerate the development of improved long-term storage options. The project expects to generate important new knowledge about how platelets deteriorate during storage, and how such deterioration can be minimized. The expected outcomes are improved methods for long term platelet storage. This should benefit blood donation services and hospitals by improving platelet delivery to remote locations, reducing wasted blood and the number of donations required, leading to significant financial savings.Read moreRead less
Minor Use Permit For Oxytetracycline In Marine And Freshwater Crustaceans
Funder
Fisheries Research and Development Corporation
Funding Amount
$75,000.00
Summary
This project will develop a Minor Use Permit application for oxytetracycline for use in crustacean aquaculture comprising: - a human health assessment focusing on worker exposure to OTC through mixing and administration - an environment assessment comprising use of existing trigger values with estimated release volumes of chemicals to understand environmental safety and to develop environmental release conditions - an efficacy and safety summary based on published information As ....This project will develop a Minor Use Permit application for oxytetracycline for use in crustacean aquaculture comprising: - a human health assessment focusing on worker exposure to OTC through mixing and administration - an environment assessment comprising use of existing trigger values with estimated release volumes of chemicals to understand environmental safety and to develop environmental release conditions - an efficacy and safety summary based on published information Assembly of these and all other relevant data into a Minor Use Permit application and submission to APVMA. Objectives: 1. Obtain a minor use permit for oxytetracycline use in crustacean aquaculture Read moreRead less
The Feasibility Of A Financial Safety-net: Investigating Financial Mechanisms To Protect Oyster Growers From Disease Outbreaks
Funder
Fisheries Research and Development Corporation
Funding Amount
$100,000.00
Summary
The oyster industry have long recognised their exposure to the unpredictable nature of the environment. Considerable time, effort and resources have been invested in risk mitigation activities. Examples such as Selective Breeding Programs, Quality Assurance Programs, Environmental Management Systems and innovations in growing techniques and animal husbandry are all designed to improve the attritubes of stock and to mitigate the likelihood & severity of a disturbance. It has been identified howev ....The oyster industry have long recognised their exposure to the unpredictable nature of the environment. Considerable time, effort and resources have been invested in risk mitigation activities. Examples such as Selective Breeding Programs, Quality Assurance Programs, Environmental Management Systems and innovations in growing techniques and animal husbandry are all designed to improve the attritubes of stock and to mitigate the likelihood & severity of a disturbance. It has been identified however, that there has been minimal investment in last resort options that support growers through worst-case scenarios.
While state & federal disaster arrangements are well established to support primary producers following declared natural disasters, the same mechanisms do not exist for disease outbreaks. Attempts to establish an aquatic deed (officially known as the aquatic EADRA - Emergency Aquatic Disease Response Arangement) have so far failed, and traditional stock insurance (such as that available to cattle producers, or ranched tuna) is not readily available to oyster farmers.
This situation has escalted following the Qx outbreak in Port Stephens, NSW. Despite suffering catastophic losses, oyster farmers in this estuary have received little support, beyond fee waivers and assistance associated with flooding events in the region. In 2019, the estuary hosted ~45 oyster farming businesses with an annual GVP of well-over $10m. Almost all of these businesses are now operating part-time, and even the most productive and profitable of growers have needed to find off-farm work to supplement their income. With considerable infrastructure in the water, farmers are unable to walk away from leases, as tipping fees alone are estimated to exceed $5m.
Understandably growers around the state have been rocked by the outbreak, the associated response and lack of financial support, and as a result have been reassessing their own exposure to risk. One thing that has also become clear, is that industry needs to take charge of their own future and look at measures to support their recovery, reestablishment or dignified exit following disease incursions.
This application seeks funding support for NSW Farmers to drive this process. This will involve the development and administration of a tender and contracting process to deliver an options document exploring the advantages and drawbacks of various financial support mechanisms current available and their appropraiteness for implementation in the oyster industry. This will include the investigation of solutions that are estbalished in other states, and other agricultural sectors. It is anticipated that recommedations put forward will be broadly split into 1) mechanisms that can be implemented at the farm/enterprise level, 2) mechanisms that may be implemented at the state/sector-wide level.
The options paper will provide valuable information which may inform the actions of fishing & aquaculture sectors around the country. Objectives: 1. By October 2024, obtain insights into potential financial support mechanisms, and their suitability for implementation in the NSW oyster industry. Read moreRead less