Transcriptional regulation of erythropoiesis. The major expected outcome from this proposal will be development of a pipeline for the study of how transcription factors work at a genome level. There will be national benefit in the areas of Frontier Technologies, and Promoting and Maintaining Good Health. There will be specific outcomes with respect to development of tests for human blood diseases, future design of drugs to target the aberrant activities of transcription factors in genetic and de ....Transcriptional regulation of erythropoiesis. The major expected outcome from this proposal will be development of a pipeline for the study of how transcription factors work at a genome level. There will be national benefit in the areas of Frontier Technologies, and Promoting and Maintaining Good Health. There will be specific outcomes with respect to development of tests for human blood diseases, future design of drugs to target the aberrant activities of transcription factors in genetic and degenerative diseases. Also, a strong bridge will be built upon the previous collaborations of the research teams in Brisbane and Pennsylvania, which will facilitate advanced teaching and training of Australian PhD and post-doctoral scientists.Read moreRead less
Defining how molecular switches program cell identity during development. Aims: This project aims to investigate how molecular switches known as transcription factors, work together to turn genes on or off to program cell identity during development.
Significance: This project expects to generate new knowledge in the area of genetics and developmental biology using collaborative, cutting edge technologies.
Outcomes: Expected outcomes of this project include the identification of new genes impor ....Defining how molecular switches program cell identity during development. Aims: This project aims to investigate how molecular switches known as transcription factors, work together to turn genes on or off to program cell identity during development.
Significance: This project expects to generate new knowledge in the area of genetics and developmental biology using collaborative, cutting edge technologies.
Outcomes: Expected outcomes of this project include the identification of new genes important for programming the identity of cells that comprise our blood vessels, lymphatic vessels and circulating blood cells.
Benefits: Data generated will underpin the development of approaches to program/reprogram stem cells to produce mature cells for transplantation or tissue engineering purposes ex vivo.Read moreRead less
An RNA interference based genetic screen for novel epigenetic modifiers involved in mammalian X inactivation. All the information required to form an adult human is contained in the DNA of the fertilized egg. Development is achieved by a complex orchestration of genes being switched on and off, controlled by proteins called epigenetic modifiers. Sometimes this goes awry, leading to disease. Despite their vital role, only around ten percent of the potential epigenetic modifiers have been characte ....An RNA interference based genetic screen for novel epigenetic modifiers involved in mammalian X inactivation. All the information required to form an adult human is contained in the DNA of the fertilized egg. Development is achieved by a complex orchestration of genes being switched on and off, controlled by proteins called epigenetic modifiers. Sometimes this goes awry, leading to disease. Despite their vital role, only around ten percent of the potential epigenetic modifiers have been characterized in humans, making it impossible to interpret how they work together, or when they fail. We will develop a novel screen-based technology to find hundreds more true epigenetic modifiers. This technology will aid us and other Australian scientists to understand the role of epigenetics in normal development and disease, ultimately leading to better public health.Read moreRead less