Improving The Long-term Quality Of Life For Preterm Children
Funder
National Health and Medical Research Council
Funding Amount
$638,517.00
Summary
My vision is to improve the long-term quality of life of preterm children (<37 weeks’ gestation), with a specific focus on those born very preterm (VP; <32 weeks’ gestation). To achieve this goal my research has two broad and related aims: 1) Determine the neurological and socio-environmental mechanisms leading to impairments in preterm children; and 2) Develop and assess the efficacy of perinatal and early intervention programs for preterm children.
Premature babies often need assistance to breathe but this can injure the lung and lead to abnormal lung development and long-term lung disease. We have recently identified 3 factors that we believe are fundamental to initiating this abnormal lung development. We will demonstrate that these 3 factors mediate abnormal lung development following lung injury at birth. This information can then be used to reduce the incidence and severity of chronic lung disease of the newborn.
Intermittent Preventive Treatment In Pregnancy With Sulphadoxine-pyrimethamine Plus Dihydroartemisinin-piperaquine To Reduce Adverse Pregnancy Outcomes And Prevent Malaria In Papua New Guinea: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$2,938,453.00
Summary
Millions of pregnancies are complicated by malaria worldwide. Monthly sulphadoxine-pyrimethamine (SP) treatments, the current treatment strategy, no longer protects from malaria but improves birth outcomes through non-malarial effects. Dihydroartemisinin-piperaquine clears malaria but babies are smaller compared to women who received SP. A clinical trial of their combination has potential to substantially improve health outcomes for women and babies in Papua New Guinea and beyond.
I am a molecular biologist-uterine biologist-placentalogist. My research focuses on the regulation of the dramatic uterine tissue remodelling during the establishment of pregnancy and placental development, and on the ultimate impact of uterine factors on
Impact Of Extreme Prematurity Or Extreme Low Birthweight On Young Adult Health And Well-Being: The Victorian Infant Collaborative Study (VICS) 1991-92 Longitudinal Cohort
Funder
National Health and Medical Research Council
Funding Amount
$725,496.00
Summary
Significant advances in medical care have increased survival of the tiniest and most premature babies. Those who have benefited from modern medicine are now in their mid-20s. We know they have more problems in childhood and adolescence compared with those born full term. However, we know little about their health problems in adulthood. This study will inform us of adult health problems in this vulnerable group and provide vital information about the best care for this increasing group of adults.
Centre For Clinical Research Excellence In Newborn Medicine
Funder
National Health and Medical Research Council
Funding Amount
$2,519,475.00
Summary
The Centre for Clinical Research Excellence in Newborn Medicine will study adverse outcomes for the brains and lungs of newborn babies; it will establish how often these occur in different types of babies (ranging from very premature babies, through to those born on time), investigate the different causes, develop treatments to either prevent or treat the adverse outcomes, determine the long-term consequences into adulthood, and continually re-evaluate the effectiveness of the various treatment ....The Centre for Clinical Research Excellence in Newborn Medicine will study adverse outcomes for the brains and lungs of newborn babies; it will establish how often these occur in different types of babies (ranging from very premature babies, through to those born on time), investigate the different causes, develop treatments to either prevent or treat the adverse outcomes, determine the long-term consequences into adulthood, and continually re-evaluate the effectiveness of the various treatment strategies designed to improve the health outcomes for newborn babies.Read moreRead less