Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to dete ....Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to detect parasite products in stool. Such testing technology is amenable to configuration in a robust format, suitable for large-scale manufacture. Given the worldwide prevalence of these parasites, the tests will have a market potential of international significance.Read moreRead less
Control of Protein Attachment and its Optical Detection. Protein array technologies have applications in the rapid diagnosis of disease. Biosensors can detect traces of biohazards. Before widespread implementation of these technologies can occur however, a rapid, sensitive and convenient readout method for the control and readout of attachment of proteins to antibodies is needed. I will use electric fields, combined with array imaging at surface plasmon resonance to achieve this aim. This protei ....Control of Protein Attachment and its Optical Detection. Protein array technologies have applications in the rapid diagnosis of disease. Biosensors can detect traces of biohazards. Before widespread implementation of these technologies can occur however, a rapid, sensitive and convenient readout method for the control and readout of attachment of proteins to antibodies is needed. I will use electric fields, combined with array imaging at surface plasmon resonance to achieve this aim. This protein diagnostic array technology will enable accurate and rapid diagnosis of disease, generating savings on health costs and improving public health. Manufacture in Australia will bring further economic benefits.Read moreRead less
Structural and pharmaceutical studies on a novel human protein, MIC-1. Cancer and obesity are two of the main health problems facing Australia, as reflected by the National Research Priority: Promoting and Maintaining Good Health. This project will develop new diagnostic tools for early cancer detection and prognosis using the protein, MIC-1. MIC-1 is responsible for cachexia, a wasting disorder responsible for 25% of cancer deaths, which has no effective therapy. MIC-1 and antibodies neutrali ....Structural and pharmaceutical studies on a novel human protein, MIC-1. Cancer and obesity are two of the main health problems facing Australia, as reflected by the National Research Priority: Promoting and Maintaining Good Health. This project will develop new diagnostic tools for early cancer detection and prognosis using the protein, MIC-1. MIC-1 is responsible for cachexia, a wasting disorder responsible for 25% of cancer deaths, which has no effective therapy. MIC-1 and antibodies neutralising MIC-1 may provide therapeutic agents to control cancer cachexia and severe obesity. The project will optimise these molecules for therapeutic uses. These diagnostic and therapeutic tools will form the basis of a spin-off company for commercialisation. Read moreRead less
New methods to improve regional isotope therapy of liver tumours in cancer patients. The most common cause of death in cancer patients is secondary tumours in vital organs. Successful treatment of liver tumours with regional isotope therapy now offers improved survival rates. This project will research novel radiolabelled nanoparticles and advanced computer imaging algorithms to improve regional isotope therapy of liver tumours. It will provide better methods of objective assessment and manageme ....New methods to improve regional isotope therapy of liver tumours in cancer patients. The most common cause of death in cancer patients is secondary tumours in vital organs. Successful treatment of liver tumours with regional isotope therapy now offers improved survival rates. This project will research novel radiolabelled nanoparticles and advanced computer imaging algorithms to improve regional isotope therapy of liver tumours. It will provide better methods of objective assessment and management that can reduce risk and improve patient survival.Read moreRead less
Intelligent Image Processing Techniques for Novel Biomarker Discovery. This project will make an impact on Australia's international research profile by seeking a solution to a worldwide challenging problem in biomarker discovery for the detection of diseases at an early stage which requires the incorporation of the skills and knowledge from biology, medicine, engineering, computer science, and information technology. The successful outcomes of this research will make an impact on Australia's e ....Intelligent Image Processing Techniques for Novel Biomarker Discovery. This project will make an impact on Australia's international research profile by seeking a solution to a worldwide challenging problem in biomarker discovery for the detection of diseases at an early stage which requires the incorporation of the skills and knowledge from biology, medicine, engineering, computer science, and information technology. The successful outcomes of this research will make an impact on Australia's engagement in using advanced image analysis and intelligent methods for the emerging research and development of targeted drug discovery. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100098
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Advanced facility for next generation sustainable energy, biomedical & nano-imaging optical fibre technologies. Remote optical fibre technologies are the way forward for effective and safe monitoring of many industries, and will play a big part in the sustainability of Australia's core oil, gas and alternative energy sectors. They are equally important to health industry applications, particularly in medical and imaging technologies. This facility brings together world-class Australian expertise ....Advanced facility for next generation sustainable energy, biomedical & nano-imaging optical fibre technologies. Remote optical fibre technologies are the way forward for effective and safe monitoring of many industries, and will play a big part in the sustainability of Australia's core oil, gas and alternative energy sectors. They are equally important to health industry applications, particularly in medical and imaging technologies. This facility brings together world-class Australian expertise—from across nine universities—in advanced structured optical fibres, complex fibre diagnostic systems, nanoscale imaging, and environment monitoring, to design and implement the next generation of technologies that will reduce the impact of climate change through reduced energy consumption and vastly improved health diagnostics.Read moreRead less