Oxide Bioceramics for Drug Delivery. Australia has the highest rate of skin cancer in the world. One out of every two Australians will develop skin cancer at some stage during their lives. On average, 740,000 new cases of skin cancer are diagnosed in Australia every year (1 million in the USA). The cost to Australia is over $200 million/year. While today more people are aware of the dangers of UV, the desire to be fashionable outweighs their health concerns. Melanotan is a novel sunscreen soluti ....Oxide Bioceramics for Drug Delivery. Australia has the highest rate of skin cancer in the world. One out of every two Australians will develop skin cancer at some stage during their lives. On average, 740,000 new cases of skin cancer are diagnosed in Australia every year (1 million in the USA). The cost to Australia is over $200 million/year. While today more people are aware of the dangers of UV, the desire to be fashionable outweighs their health concerns. Melanotan is a novel sunscreen solution: a drug that stimulates the body's natural defence mechanism against UV light. Alumina and zirconia bioceramics are ideal implantable drug delivery vehicles because of the long leaching periods possible.Read moreRead less
Design Optimisation for Fabrication of Ceramic Prosthetic Devices. The project aims to develop computer aided design and fabrication for ceramic prosthesis. It will help establish a world-class biomedical instrumentation company having part of its research and development in Australia. The study will not only foster domestic research expertise, but also provide the local prosthetic community and biomedical industry with an opportunity to participate in further innovation of biomaterials, biomedi ....Design Optimisation for Fabrication of Ceramic Prosthetic Devices. The project aims to develop computer aided design and fabrication for ceramic prosthesis. It will help establish a world-class biomedical instrumentation company having part of its research and development in Australia. The study will not only foster domestic research expertise, but also provide the local prosthetic community and biomedical industry with an opportunity to participate in further innovation of biomaterials, biomedical software and equipment. The outcomes will directly benefit the Australian prosthetic profession. Improvement in prosthesis restorative longevity for our increasing ageing population will support the national research goal of ageing well, ageing productively.Read moreRead less
Formation of bone-like materials for bone repair and regeneration. A successful outcome for this project would lead to the production and application of new bone-like calcium phosphate materials. Enhanced bioactivity of this material would lead to higher but controlled rates of calcium phosphate release. An understanding of the formation process of these materials and the controlled release of calcium phosphates has the potential to slow the development of metabolic diseases such as osteoporosis ....Formation of bone-like materials for bone repair and regeneration. A successful outcome for this project would lead to the production and application of new bone-like calcium phosphate materials. Enhanced bioactivity of this material would lead to higher but controlled rates of calcium phosphate release. An understanding of the formation process of these materials and the controlled release of calcium phosphates has the potential to slow the development of metabolic diseases such as osteoporosis. The WHO reports that osteoporosis is the second largest health care problem world-wide. In 2002, 44 million people in the USA were estimated to be at risk. This and similar figures in Australia and around the world emphasize the urgency of understanding and appropriately combating weak bone degenerative diseases.Read moreRead less
Failure of Complex Biomechanical Structures. Layer structures are replete in biological systems, both natural and artificial. Issues concerning the lifetime of such systems are paramount to the quality of life and economic well being of our aging society. Our project will analyse damage in brittle layer systems that simulate dental crown structures. We are now at a critical point in the understanding of how these structures fail, and are beginning to make substantive predictions to improve des ....Failure of Complex Biomechanical Structures. Layer structures are replete in biological systems, both natural and artificial. Issues concerning the lifetime of such systems are paramount to the quality of life and economic well being of our aging society. Our project will analyse damage in brittle layer systems that simulate dental crown structures. We are now at a critical point in the understanding of how these structures fail, and are beginning to make substantive predictions to improve designs for prolonged life. The project is connected to the dental community and international crown material manufacturers through a broader NIH project in the USA. The improved materials and crown designs resulting from this project will have impact worldwide, including Australia.Read moreRead less
Failure of Worn Tooth Structures. Layer structures are replete in biological systems, both natural and artificial. Issues concerning the lifetime of such systems are paramount to the quality of life and economic well being of our aging society. Our project will analyse damage in brittle layer systems that simulate natural teeth and dental crown structures that have been subject to wear. The project is connected to the dental community and international crown material manufacturers through a bro ....Failure of Worn Tooth Structures. Layer structures are replete in biological systems, both natural and artificial. Issues concerning the lifetime of such systems are paramount to the quality of life and economic well being of our aging society. Our project will analyse damage in brittle layer systems that simulate natural teeth and dental crown structures that have been subject to wear. The project is connected to the dental community and international crown material manufacturers through a broader National Institutes of Health project in the USA. The improved understanding of damage mechanisms in natural teeth and crown designs resulting from this project will have impact worldwide, including Australia.Read moreRead less
X-Ray Activation of Photocatalytic Titania-Coated Biomedical Implants in Situ. The main causes of biomedical implant failure are loosening and infection, which may require revision surgery. The project has the potential to solve these widespread and expensive problems by formation of a coating of strongly (chemically) bonded and photocatalytically active titania on the titanium implant surface and short-term low-dose X-irradiation. This work has the potential to provide the biomedical industry w ....X-Ray Activation of Photocatalytic Titania-Coated Biomedical Implants in Situ. The main causes of biomedical implant failure are loosening and infection, which may require revision surgery. The project has the potential to solve these widespread and expensive problems by formation of a coating of strongly (chemically) bonded and photocatalytically active titania on the titanium implant surface and short-term low-dose X-irradiation. This work has the potential to provide the biomedical industry with a revolutionary development in both implant coating design and quality with self-disinfection capacity after implantation.Read moreRead less
Crack Propagation within Graded Interfaces. Functionally graded interfaces are a technologically new way of joining materials in a wide range of biomedical and industrial applications. The reduction in the interfacial stresses resulting from the graded interface increases the structural integrity of the component, however, existing models do not fully address issues of plasticity and cyclic fatigue to their fracture. The intention of this study is to investigate how modifications to the ductil ....Crack Propagation within Graded Interfaces. Functionally graded interfaces are a technologically new way of joining materials in a wide range of biomedical and industrial applications. The reduction in the interfacial stresses resulting from the graded interface increases the structural integrity of the component, however, existing models do not fully address issues of plasticity and cyclic fatigue to their fracture. The intention of this study is to investigate how modifications to the ductile reinforcement phase and how the cyclic loading influence crack extension within a graded interface. These results will assist in future design and prediction of the in-service lifetime of components containing gradient interfaces.Read moreRead less
Some Outstanding Mechanics Problems in Layered Ferroelectromagnetic Composites with Enhanced Magnetoelectric Effect. The proposed research has high impact on both science and technology of ferroelectromagnetic materials. The outcomes will expand Australia's knowledge base and research capability in this emerging field. Relevant industries, such as smart materials and devices, can benefit from the results of this project. The theoretical, experimental and numerical results can be directly transfo ....Some Outstanding Mechanics Problems in Layered Ferroelectromagnetic Composites with Enhanced Magnetoelectric Effect. The proposed research has high impact on both science and technology of ferroelectromagnetic materials. The outcomes will expand Australia's knowledge base and research capability in this emerging field. Relevant industries, such as smart materials and devices, can benefit from the results of this project. The theoretical, experimental and numerical results can be directly transformed to design and application guidelines for the materials engineers and scientists to develop innovative and structurally/functionally reliable ferroelectromagnetic composites and their various devices and products.Read moreRead less
Surface Polymorphism of Hard Brittle Materials. The knowledge gained from this project will be of great value in creating components of hard brittle materials with enhanced properties and expanded margins of application. The outcome will have impact on the ultra-precision manufacturing giving a competitive edge to the Australian fabrication industry. The fundamental knowledge gained from this project has the potential to facilitate the development of new devices and techniques such as those requ ....Surface Polymorphism of Hard Brittle Materials. The knowledge gained from this project will be of great value in creating components of hard brittle materials with enhanced properties and expanded margins of application. The outcome will have impact on the ultra-precision manufacturing giving a competitive edge to the Australian fabrication industry. The fundamental knowledge gained from this project has the potential to facilitate the development of new devices and techniques such as those required for bio-medical, photonic and electronic technologies.Read moreRead less
Engineering of Crystalline Ternary Ceramic Precursors. Ti3SiC2 belongs to a large group of ternary carbides that exhibit an unique combination of high temperature ceramic properties, with the electrical and thermal conductivity of metals. A great number of potential applications have been identified, but are currently limited by residual intermediate compounds, that degrade the properties. This project will use crystal structure similarities between TiCx and Ti3SiC2 to engineer a crystalline pre ....Engineering of Crystalline Ternary Ceramic Precursors. Ti3SiC2 belongs to a large group of ternary carbides that exhibit an unique combination of high temperature ceramic properties, with the electrical and thermal conductivity of metals. A great number of potential applications have been identified, but are currently limited by residual intermediate compounds, that degrade the properties. This project will use crystal structure similarities between TiCx and Ti3SiC2 to engineer a crystalline precursor, Ti3C2, which circumvents intermediate compound formation. This innovative methodology will also reduce the cost and time of fabrication. Advanced in-situ neutron diffraction techniques will be used to quantify the synthesis kinetics and optimize the method.Read moreRead less