Multimodal Electrically Conducting Bionic Implant For Long-distance Oriented Axonal Regeneration
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Neurotrauma, defined as an injury to the central nervous system, is a debilitating medical condition affecting over 3 million people annually worldwide. Loss of function following injury is largely due to the limited potential of nerve cells to regenerate. I will develop a bionic platform that conducts electrical signals and delivers growth promoting proteins thereby enhancing the directed regeneration of nerve cells necessary to bridge the gap caused by the injury and restore organ function.
The Effect Of Titanium Surface Modification On The Immuno-regulation Of Osseointegration.
Funder
National Health and Medical Research Council
Funding Amount
$308,713.00
Summary
Titanium implants are an established treatment modality in both dentistry and orthopaedics. This project will determine how implant surface modification can modulate the inflammatory response and subsequent differentiation of stem cells involved in the process of integrating the implant with bone i.e. osseointegration. The identification of the molecular mechanisms involved will thus provide leads for novel ways to further to enhance the osseointegration process and improve clinical outcomes.
Functional Nano-cement Scaffolds For The Treatment Of Osteoporotic Bone Defects
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
Osteoporosis affects 1.2 million Australians and will cost $33.6 billion by 2022. This study aims to develop a novel nano-cement platform for custom-designed bone repair in osteoporosis, by using purpose-designed nanomaterials and advanced 3D printing technique. The research findings will lead to the development of a new bone repair strategy, expand knowledge on both biomaterials engineering and osteoporosis treatment, and improve the quality of life of Australians.
Photonic Crystals For Probing Enzyme Activity: Single Cells Vs Bulk Measurements
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
We are all unique and we are unique down to a single cell. Can we understand the behaviour of a single cell? A novel biosensing platform will be developed to detect biological activity of single cells by simple measurement of a colour change. Successful fabrication of this biosensor will aid in the development of diagnostic devices for predictive and preventive medicine.
There is an urgent need for engineered tissue repair and replacement components for cartilage implantation in damaged joints due to a shortage of donor tissue. This project will generate smart composite biomaterials with enhanced mechanical strength and physical properties that are desirable for cartilage repair. The fabricated scaffolds will mimic the microstructure of native cartilage and are next-generation biomaterials designed to facilitate cartilage regeneration.
Development Of Gene-activated Scaffolds As Bone Bioreactor For Bone Regeneration And Osteointegration
Funder
National Health and Medical Research Council
Funding Amount
$215,100.00
Summary
The worldwide market for bone substitutes has been estimated at over US $1 billion annually. The emerging technology of cell based therapy has opened a new window for the treatment of bone defects. This project is to develop gene-activated scaffolds able to induce blood vessel formation thus improving the local nutrition supply, and subsequently stimulating bone formation in bone defects, as well as osteointegration around implant surface. The knowledge generated from this project will help the ....The worldwide market for bone substitutes has been estimated at over US $1 billion annually. The emerging technology of cell based therapy has opened a new window for the treatment of bone defects. This project is to develop gene-activated scaffolds able to induce blood vessel formation thus improving the local nutrition supply, and subsequently stimulating bone formation in bone defects, as well as osteointegration around implant surface. The knowledge generated from this project will help the treatment of a number of orthopaedic and dental conditions.Read moreRead less
A Novel Strategy For The Treatment Of Chronic Skeletal Joint Defects
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Skeletal joint injuries often heal poorly with current treatment approaches and lead to the onset of osteoarthritis. This project will produce a synthetic graft with unique properties to mimic the complex structure of joint tissues, and high bioactivity to induce optimal healing of the joint. This graft will constitute a viable alternative for the treatment of skeletal joint defects, resulting in significant healthcare benefits and improved long-term outcomes.
Novel Strategy For The Treatment Of Large Bone Defects Using A Unique Biomaterial With Tailored Microstructure
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
There is a rapidly increasing and pressing medical need for the development of synthetic implants that can regenerate large amounts of lost or diseased bone. This project will produce a unique implant with optimal mechanical and biological performance, which represents a viable alternative to bone grafting with broad applications for the repair of large or challenging bone defects. Such an achievement will produce significant healthcare benefits and improved long-term outcomes.
Smart Hybrid Material For Cartilage Tissue Engineering
Funder
National Health and Medical Research Council
Funding Amount
$299,564.00
Summary
Tissue engineering is a promising approach to repair damaged/degenerated cartilage caused by various diseases or injuries. Because of its limited capacity for self repair cartilage becomes a constriant to normal everyday life once degenerated. This project aims to develop composite polymers for cartilage repair. The potential of this newly developed material for cartilage tissue engineering will be investigated through the material and biological characterisation techniques.