Discovery Early Career Researcher Award - Grant ID: DE120100907
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
The brain, maths and space: their interaction in health and disease. This project investigates how thinking about numbers affects how we think about the space that surrounds us - and vice versa. Investigations of commonalities in the neural and cognitive processing of space and numbers may lead to the development of innovative therapies for people suffering from attentional disorders after brain damage.
The articulate brain. Language is essential to human interaction, yet we know comparatively little about the mental processes involved and how they are represented in the brain, how genetic and environmental factors contribute to the development of language, or how effective treatments of language disorders work. The significance of this program of research lies in its capacity to enhance our understanding of a range of mechanisms responsible for a fundamentally human ability, and provide inform ....The articulate brain. Language is essential to human interaction, yet we know comparatively little about the mental processes involved and how they are represented in the brain, how genetic and environmental factors contribute to the development of language, or how effective treatments of language disorders work. The significance of this program of research lies in its capacity to enhance our understanding of a range of mechanisms responsible for a fundamentally human ability, and provide information that will ultimately inform clinical practice. In particular, new knowledge about the brain mechanisms involved in language processing and recovery will inform clinicians about the optimal choice of treatment to maximise outcomes for the individual patient. Read moreRead less
How does dopamine modulate adult new word learning? Stroke is a chronic disease of increasing prevalence with increasing age. There is a critical need to develop more effective treatments of communication disorders in this population. One way of achieving this is to combine certain drugs with language therapy. Through studying how these drugs influence language, this research will provide vital knowledge for developing effective forms of pharmacotherapy for adults with language disorders after b ....How does dopamine modulate adult new word learning? Stroke is a chronic disease of increasing prevalence with increasing age. There is a critical need to develop more effective treatments of communication disorders in this population. One way of achieving this is to combine certain drugs with language therapy. Through studying how these drugs influence language, this research will provide vital knowledge for developing effective forms of pharmacotherapy for adults with language disorders after brain injury. More effective language rehabilitation can have direct positive consequences on the ability to regain and maintain employment and social relationships after stroke or brain injury and will address the large and growing social and economic cost to the nation.Read moreRead less
A functional imaging study of semantic processing modulated by dopamine. The role of dopamine in language processing is largely unknown, despite emerging evidence that dopaminergic alterations can modulate language in schizophrenia, Parkinson's disease, and healthy individuals. The research aims to reveal the neural and behavioural correlates of dopaminergic modulation of semantic processing using neuroimaging in healthy individuals who have ingested levodopa. It is hypothesised that levodopa wi ....A functional imaging study of semantic processing modulated by dopamine. The role of dopamine in language processing is largely unknown, despite emerging evidence that dopaminergic alterations can modulate language in schizophrenia, Parkinson's disease, and healthy individuals. The research aims to reveal the neural and behavioural correlates of dopaminergic modulation of semantic processing using neuroimaging in healthy individuals who have ingested levodopa. It is hypothesised that levodopa will modulate brain activity under circumstances where there is heightened semantic competition, consistent with a contemporary theory of dopaminergic cognitive control. The expected outcome of the research is an increased understanding of the interactions between dopamine, the language faculty, and associated neural systems.Read moreRead less
ELEMENTS: A Virtual-Reality Augmented Workspace for Movement Rehabilitation of Traumatic Brain Injury Patients. The broad aim of the project is to design, develop and evaluate an interactive virtual environment (VE) called ELEMENTS that supports movement assessment and rehabilitation for patients recovering from Traumatic Brain Injury (TBI). We will use current knowledge of the neural basis of movement control and learning to create VEs that will help re-train patients' sense of multimodal space ....ELEMENTS: A Virtual-Reality Augmented Workspace for Movement Rehabilitation of Traumatic Brain Injury Patients. The broad aim of the project is to design, develop and evaluate an interactive virtual environment (VE) called ELEMENTS that supports movement assessment and rehabilitation for patients recovering from Traumatic Brain Injury (TBI). We will use current knowledge of the neural basis of movement control and learning to create VEs that will help re-train patients' sense of multimodal space, their position within it, and the predictive control of actions. We will adapt our training environments for use on readily available technologies, creating a treatment method amenable to remote delivery. This will extend rehabilitation practices beyond their current constraints.Read moreRead less
The relationship between cognitive capacity and driver competence following acquired brain injury: Implications for driver rehabilitation and training. This project develops a model of driver rehabilitation and training, based on speed of information processing variables, for people with acquired brain injuries (ABI). Current evaluations of fitness to drive lack sufficient theoretical and empirical foundations. Consequent problems include inappropriate decisions about fitness to drive, comprom ....The relationship between cognitive capacity and driver competence following acquired brain injury: Implications for driver rehabilitation and training. This project develops a model of driver rehabilitation and training, based on speed of information processing variables, for people with acquired brain injuries (ABI). Current evaluations of fitness to drive lack sufficient theoretical and empirical foundations. Consequent problems include inappropriate decisions about fitness to drive, compromised driver safety, and inadequate driver training. Accurate assessment of ABI processing deficits will generate driver-training programs tailored to individual needs. The project also addresses rehabilitation and training outcomes, particularly as they relate to reduced social services needs and enhanced quality of life. It provides a paradigm for evaluating rehabilitation outcomes in wider contexts.
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Discovery Early Career Researcher Award - Grant ID: DE180100741
Funder
Australian Research Council
Funding Amount
$342,996.00
Summary
Harnessing neural plasticity with brain stimulation. This project aims to investigate the links between the molecular mechanisms underlying brain plasticity and the effects of non-invasive brain stimulation. It will use a novel approach that integrates genetics, electrophysiology and biological modelling. Plasticity underpins all learning, memory and aging. Brain stimulation can drive plasticity in humans, but these effects are extremely difficult to harness and vary widely between people. Expec ....Harnessing neural plasticity with brain stimulation. This project aims to investigate the links between the molecular mechanisms underlying brain plasticity and the effects of non-invasive brain stimulation. It will use a novel approach that integrates genetics, electrophysiology and biological modelling. Plasticity underpins all learning, memory and aging. Brain stimulation can drive plasticity in humans, but these effects are extremely difficult to harness and vary widely between people. Expected outcomes include a critical understanding of the fundamental mechanisms governing plasticity. This will provide significant benefits such as the development of individually optimised brain stimulation protocols, enabling tailored, reliable approaches to address brain function and cognition.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100694
Funder
Australian Research Council
Funding Amount
$372,014.00
Summary
Does disconnection in the aging brain cause age-related movement decline? This project aims to use new neurophysiological approaches to understand the causal role of age-related changes in brain network connectivity to the movement control. Brain regions interact through complex and dynamic neural networks to control voluntary movement, but whether age-related changes in network connectivity drive age-related decline in movement control is unknown. This project will provide significant benefits ....Does disconnection in the aging brain cause age-related movement decline? This project aims to use new neurophysiological approaches to understand the causal role of age-related changes in brain network connectivity to the movement control. Brain regions interact through complex and dynamic neural networks to control voluntary movement, but whether age-related changes in network connectivity drive age-related decline in movement control is unknown. This project will provide significant benefits such as the neurophysiological knowledge required to develop targeted interventions to improve movement control in the aging population.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100575
Funder
Australian Research Council
Funding Amount
$423,604.00
Summary
Does neuroplasticity protect against late life cognitive impairment? This project aims to investigate neuroplasticity across the adult lifespan, using novel neurophysiological approaches to determine its role in protecting against age-related cognitive decline. This project expects to generate new knowledge in the area of human cognitive ageing, using an innovative and interdisciplinary approach. Expected outcomes of this project include a critical understanding of the basic neural mechanisms of ....Does neuroplasticity protect against late life cognitive impairment? This project aims to investigate neuroplasticity across the adult lifespan, using novel neurophysiological approaches to determine its role in protecting against age-related cognitive decline. This project expects to generate new knowledge in the area of human cognitive ageing, using an innovative and interdisciplinary approach. Expected outcomes of this project include a critical understanding of the basic neural mechanisms of healthy brain ageing. This will provide significant benefits, such as the neurophysiological knowledge required to develop novel biological markers to detect, as well as therapeutic agents to curb, cognitive decline in the aging population.Read moreRead less
Understanding working memory: from cells to brain stimulation. This project aims to understand the neural mechanisms of working memory, a fundamental cognitive function in humans, using a novel framework which combines non-invasive brain stimulation, neuroimaging, pharmacological and experimental manipulations, and biological modelling. Expected outcomes include a critical understanding of the cellular mechanisms underlying both neural activity and working memory ability in healthy individuals a ....Understanding working memory: from cells to brain stimulation. This project aims to understand the neural mechanisms of working memory, a fundamental cognitive function in humans, using a novel framework which combines non-invasive brain stimulation, neuroimaging, pharmacological and experimental manipulations, and biological modelling. Expected outcomes include a critical understanding of the cellular mechanisms underlying both neural activity and working memory ability in healthy individuals and a detailed knowledge of how to non-invasively interact with these mechanisms using brain stimulation. This will provide significant benefits such as the development of individually optimised brain stimulation protocols, enabling tailored approaches to reliably alter brain function and cognition.Read moreRead less