A Randomised Controlled Trial Of Alternative Treatments To Intramuscular Penicillin For Impetigo In Aboriginal Children
Funder
National Health and Medical Research Council
Funding Amount
$1,326,182.00
Summary
We will conduct clinical trials to find an effective, simple and cheap oral alternative to injected penicillin for skin sores which could become the universal standard of care whether the patient is in Melbourne or Milingimbi. It would also likely be adopted by the World Health Organization as a standard of care for developing countries. This would lead directly to a reduced burden of skin sores and their complications. It would also open the way for studies to explore even simpler regimens.
Skin Microbes and Animal Health: Understanding the Ecological Context. This project aims to understand the fundamental ecological relationships between animal hosts (frogs, geckos) and bacteria on their skin by separating host effects from environmental factors that determine skin microbiome composition. The research is significant because it will generate new knowledge needed to understand how skin microbes function in providing protection against disease. Expected outcomes include the provisio ....Skin Microbes and Animal Health: Understanding the Ecological Context. This project aims to understand the fundamental ecological relationships between animal hosts (frogs, geckos) and bacteria on their skin by separating host effects from environmental factors that determine skin microbiome composition. The research is significant because it will generate new knowledge needed to understand how skin microbes function in providing protection against disease. Expected outcomes include the provision of essential information that will guide future research efforts on the factors that determine a healthy skin microbial community (which is needed before skin diseases can be combated). The research will provide significant benefits, including more targeted conservation efforts to combat wildlife skin diseases.Read moreRead less
Learning to Talk, Talking to Learn: Effects of an early childhood language program in remote Northern Territory indigenous communities. Both the quality and quantity of language children hear, and adult understandings of child development, drive children's future outcomes. Understanding how to improve both is critical to the lifelong education, employment and social potential of children from low socioeconomic families, especially with hearing loss. This project aims to examine to what extent a ....Learning to Talk, Talking to Learn: Effects of an early childhood language program in remote Northern Territory indigenous communities. Both the quality and quantity of language children hear, and adult understandings of child development, drive children's future outcomes. Understanding how to improve both is critical to the lifelong education, employment and social potential of children from low socioeconomic families, especially with hearing loss. This project aims to examine to what extent a parent-implemented early childhood language program designed to buffer against effects of childhood otitis media can support indigenous children in remote northern Australia. Outcomes aim to be data on effects on children's language, attention, and school readiness, plus uptake of strategies and knowledge by parents and other adults, and evidence regarding best practice in such contexts.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100015
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
An Ultra High Resolution Mass Spectrometry Facility for Lipidomics Research. An ultra-high-resolution mass spectrometry facility for lipidomics research:
This proposal aims to establish an ultra-high-resolution, accurate mass spectrometry facility in Australia for comprehensive lipidomics research. The platform would consist of a Thermo Scientific Orbitrap Fusion mass spectrometer interfaced with ultra-high-pressure high-performance liquid chromatography. This proposal will address a major need ....An Ultra High Resolution Mass Spectrometry Facility for Lipidomics Research. An ultra-high-resolution mass spectrometry facility for lipidomics research:
This proposal aims to establish an ultra-high-resolution, accurate mass spectrometry facility in Australia for comprehensive lipidomics research. The platform would consist of a Thermo Scientific Orbitrap Fusion mass spectrometer interfaced with ultra-high-pressure high-performance liquid chromatography. This proposal will address a major need for advanced mass spectrometry-based lipid analysis capabilities across mammalian, plant, parasite, and microalgae research disciplines, as well as enabling fundamental studies of lipid separation, chemistry and reactivity. The instrumentation would be applicable to a diverse range of projects including studies of the role of lipid metabolism in mammalian biochemistry and cell biology, plant biology and parasitology, and micro algae biofuel production.Read moreRead less
Competition between regulatory processes in Amphibians: Testing the effects of physical and physiological factors on thermoregulation and hydroregulation. Regulation of body temperature is important for many animals, and it influences processes such as growth and reproduction. However, it is not clear to what extent wet-skinned animals can control body temperature because of evaporation. Understanding this about frogs is crucial to understanding their habitat requirements and the effects of clim ....Competition between regulatory processes in Amphibians: Testing the effects of physical and physiological factors on thermoregulation and hydroregulation. Regulation of body temperature is important for many animals, and it influences processes such as growth and reproduction. However, it is not clear to what extent wet-skinned animals can control body temperature because of evaporation. Understanding this about frogs is crucial to understanding their habitat requirements and the effects of climate change, habitat modification, and the invasion of cane toads on their populations. Amphibians are in decline worldwide, and research into the basic ways that these animals interact with the physical environment is needed before effective management plans can be produced. The unique physiological characteristics of Australian frogs make this is the best place in the world to do this research.Read moreRead less
Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying ....Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying regulators of lipid metabolism. The large diversity in humans necessitate sufficient sample sizes to identify true genetic regulators, but to date techniques capturing phenotypic data (lipids) have been largely limited. It is anticipated that this study will identify new regulators of lipid metabolism in humans.Read moreRead less
Integrative assessment of disturbance and land-use change on total greenhouse gas balance and nutrient cycling in savanna ecosystems. Climate change and variability is expected to have an impact on the NT environment and economy. This project will enable NT specific calibrations of climate variability-land use models, such as the National Carbon Accounting System. The NT Government will have access to a high quality database and calibrated models relating to greenhouse gas emissions as a functio ....Integrative assessment of disturbance and land-use change on total greenhouse gas balance and nutrient cycling in savanna ecosystems. Climate change and variability is expected to have an impact on the NT environment and economy. This project will enable NT specific calibrations of climate variability-land use models, such as the National Carbon Accounting System. The NT Government will have access to a high quality database and calibrated models relating to greenhouse gas emissions as a function of land use change. The project will improve estimates and management of GHG and provide a basis for the NT to potentially exploit future carbon-trading initiatives or GHG abatement schemes as fundamental data describing emissions as a function of land use will be available. This is of national significance given the size of the savanna biome in Australia.Read moreRead less
How does habitat complexity drive motor ageing and fitness in wild mammals? This project aims to demonstrate how habitat complexity shapes motor ageing in wild dasyurid marsupials, and to improve these animals’ motor function, slow its decline and increase reproductive output via behavioural and physiological changes. Motor decline should dramatically impact an animal growth, survival and reproduction by affecting how it moves through habitats when foraging, seeking mates, or escaping from preda ....How does habitat complexity drive motor ageing and fitness in wild mammals? This project aims to demonstrate how habitat complexity shapes motor ageing in wild dasyurid marsupials, and to improve these animals’ motor function, slow its decline and increase reproductive output via behavioural and physiological changes. Motor decline should dramatically impact an animal growth, survival and reproduction by affecting how it moves through habitats when foraging, seeking mates, or escaping from predators. However, little is known about the environmental drivers of motor ageing in wild animals. Our project addresses an important gap in the field of evolutionary ecology. Since decline in muscle function affects the quality of Australian's life, our work could lead to important economic and health implications.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989147
Funder
Australian Research Council
Funding Amount
$950,000.00
Summary
Advanced high throughput genomics facility for biological, medical, agricultural, environmental and evolutionary research. Infrastructure requested will expand the capacity of researchers in NSW/NT to undertake environmental, medical and evolutionary studies using state-of-the-art technologies based on the recent advances in DNA sequencing analyses. It will ensure the retention of leading researchers in the exciting areas of genomics and Systems Biology and make a significant contribution to bi ....Advanced high throughput genomics facility for biological, medical, agricultural, environmental and evolutionary research. Infrastructure requested will expand the capacity of researchers in NSW/NT to undertake environmental, medical and evolutionary studies using state-of-the-art technologies based on the recent advances in DNA sequencing analyses. It will ensure the retention of leading researchers in the exciting areas of genomics and Systems Biology and make a significant contribution to biomolecular research in medicine, agriculture and environmental biology, thereby providing major benefits to the wider community. The application will enhance existing genomic technologies by substantially increasing the scope of experiments that can be performed leading to important advances in gene discovery.Read moreRead less
ARC Research Network for Understanding and Managing Australian Biodiversity. Biodiversity research is strong in Australia but is highly uncoordinated and, along with recent major breakthroughs in both theory and techniques, has highlighted the need for a Network to properly integrate research and focus it on the most appropriate scale. This Network aims to bring together a diverse spectrum of highly experienced and early career researchers to pool their ideas and expertise to allow them to deter ....ARC Research Network for Understanding and Managing Australian Biodiversity. Biodiversity research is strong in Australia but is highly uncoordinated and, along with recent major breakthroughs in both theory and techniques, has highlighted the need for a Network to properly integrate research and focus it on the most appropriate scale. This Network aims to bring together a diverse spectrum of highly experienced and early career researchers to pool their ideas and expertise to allow them to determine how best to describe Australia's current biodiversity and the biological and environmental history leading up to the present. A major outcome will be the ability to predict the impacts of environmental change on biodiversity to assist management decisions across Australia, with lessons of global importance.Read moreRead less