Elucidating structure and function of activation-associated secreted proteins (ASPs) in blood-feeding hookworms – toward new methods of control. The national/community benefits are: (1) to develop a long-term, high quality scientific and technological program contributing to national objectives, including the maintenance of a strong capability in basic research, the development of new scientific concepts and the enhancement of international collaborative links; (2) to strengthen the links betwee ....Elucidating structure and function of activation-associated secreted proteins (ASPs) in blood-feeding hookworms – toward new methods of control. The national/community benefits are: (1) to develop a long-term, high quality scientific and technological program contributing to national objectives, including the maintenance of a strong capability in basic research, the development of new scientific concepts and the enhancement of international collaborative links; (2) to strengthen the links between basic and applied research; (3) to develop excellence in research by promoting collaborative research, resulting in a more efficient use of resources in a national and international context; (4) to enhance the skills-base in biology and biotechnology; (5) to substantially increase global visibility through quality research, leading to an increased investment in Australian science.Read moreRead less
Mitogenomics using a massively parallel reactor platform - from barcoding to diagnostic tools for pathogens of major socioeconomic importance. The national/community benefits are: (1) to develop a long-term, high quality scientific and technological program contributing to national objectives, including the maintenance of a strong capability in basic research, the development of new scientific concepts and the enhancement of international collaborative links; (2) to strengthen the links between ....Mitogenomics using a massively parallel reactor platform - from barcoding to diagnostic tools for pathogens of major socioeconomic importance. The national/community benefits are: (1) to develop a long-term, high quality scientific and technological program contributing to national objectives, including the maintenance of a strong capability in basic research, the development of new scientific concepts and the enhancement of international collaborative links; (2) to strengthen the links between basic and applied research; (3) to develop excellence in research by promoting collaborative research, resulting in a more efficient use of resources in a national and international context; (4) to enhance the skills-base in biology and biotechnology; (5) to substantially increase global visibility through quality research, leading to an increased investment in Australian science.
Read moreRead less
Mass Spectrometric Investigations of Conformation and Dynamics of Biological Complexes. The new collaboration between the leading mass spectrometry groups at University Wollongong and Cambridge University will benefit both partners. Researchers at Wollongong will have access to an ion mobility mass spectrometry technology not currently available in Australia that will contribute to our understanding of complicated cellular processes such as chromosome replication. The researchers' experience wit ....Mass Spectrometric Investigations of Conformation and Dynamics of Biological Complexes. The new collaboration between the leading mass spectrometry groups at University Wollongong and Cambridge University will benefit both partners. Researchers at Wollongong will have access to an ion mobility mass spectrometry technology not currently available in Australia that will contribute to our understanding of complicated cellular processes such as chromosome replication. The researchers' experience with this technology will pave the way for introduction of the technology to Australia and benefit the wider scientific community in wide-ranging projects such as development of new antibiotics and vaccines. Students from both institutions will benefit from experiencing science from an international perspective.Read moreRead less
Bioinformatics network for the interrogation of adult stem cells. This project addresses the National Research Priority 'Frontier Technologies for Building and Transforming Australian Industries'. The use of state of the art DNA sequencing results in huge amounts of data that is hard to interpret without the use of computers. This project builds Australia's capacity to deal with huge biological datasets by creating software and expertise in handling these datasets. The application of this softwa ....Bioinformatics network for the interrogation of adult stem cells. This project addresses the National Research Priority 'Frontier Technologies for Building and Transforming Australian Industries'. The use of state of the art DNA sequencing results in huge amounts of data that is hard to interpret without the use of computers. This project builds Australia's capacity to deal with huge biological datasets by creating software and expertise in handling these datasets. The application of this software and expertise to our stem cell population in Parkinson's disease patients will enable new insight into the difference between patients and controls.Read moreRead less
Special Research Initiatives - Grant ID: SR0567460
Funder
Australian Research Council
Funding Amount
$85,000.00
Summary
Development of a collaborative environment for high throughput biology discovery pipelines. Modern biological science involves the parallel high-throughput investigation of many hundreds of different experimental targets. Traditional approaches for recording, analysing, mining and cross comparing experimental data are inadequate for conducting high throughput experiments. This proposal aims to develop new algorithms in the high throughput arena that will revolutionize biological discovery.
Infrakingdom Alveolata: searching for a defining structural feature. This project will establish the first molecular nexus between a cellular structure currently used to define an Infrakingdom of life. It will aid in the higher order systematics of our microscopic diversity and allow us to interpret how important parasites learned to penetrate host cells to establish infection. We will train excellent graduate and Honours students in cellular and molecular biology.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347727
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Computational infrastructure for high-throughput genome bioinformatics. We propose a high-performance computing and web facility for genome bioinformatics. It will provide a common software development environment in support of molecular biosciences, systems biology and complex systems modelling at the Institute for Molecular Bioscience at University of Queensland, and at Queensland University of Technology. The platform will support Australia's first genome-scale bioinformatics research website ....Computational infrastructure for high-throughput genome bioinformatics. We propose a high-performance computing and web facility for genome bioinformatics. It will provide a common software development environment in support of molecular biosciences, systems biology and complex systems modelling at the Institute for Molecular Bioscience at University of Queensland, and at Queensland University of Technology. The platform will support Australia's first genome-scale bioinformatics research website, with unique software and mirrors of the IBM Biological Pattern Discovery, UC San Diego MEME/MetaMEME/MAST, and NGI comparative genomics websites. Australian/NZ researchers will access the facility at no cost for high-throughput use of unique software, website mirrors and other important tools for genome bioinformatics.Read moreRead less
Who were the ancestors of Homo floresiensis? The discovery of a tiny, new hominid species living in Indonesia until just 12,000 years ago, at the same time as modern humans in the region, has sparked world-wide public interest and debate. Finding the ancestors of this species will further promote Australian research as high profile, high calibre and cutting edge. Collaboration with researchers and institutions in Indonesia, USA, Kenya, Tanzania, South Africa and the Republic of Georgia will stre ....Who were the ancestors of Homo floresiensis? The discovery of a tiny, new hominid species living in Indonesia until just 12,000 years ago, at the same time as modern humans in the region, has sparked world-wide public interest and debate. Finding the ancestors of this species will further promote Australian research as high profile, high calibre and cutting edge. Collaboration with researchers and institutions in Indonesia, USA, Kenya, Tanzania, South Africa and the Republic of Georgia will strengthen our links with these nations.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347962
Funder
Australian Research Council
Funding Amount
$218,000.00
Summary
Adelaide Mass Spectrometry and Analysis Facility. This joint proposal by two South Australian universities and the Hanson Institute seeks to establish a facility for rapid characterisation and identification of biomolecules by means of MALDI-TOF and Nano LC mass spectrometry. The requested equipment is not available in South Australia. This proposal would establish a Nano LC (Q-TOF) node at the University of Adelaide-University of South Australia location and a MALDI-TOF node at the Flinders loc ....Adelaide Mass Spectrometry and Analysis Facility. This joint proposal by two South Australian universities and the Hanson Institute seeks to establish a facility for rapid characterisation and identification of biomolecules by means of MALDI-TOF and Nano LC mass spectrometry. The requested equipment is not available in South Australia. This proposal would establish a Nano LC (Q-TOF) node at the University of Adelaide-University of South Australia location and a MALDI-TOF node at the Flinders location. Its presence would greatly enhance the quality of research and teaching in priority areas such as proteomics, bioinformatics and nanotechnology and would provide a basis for fostering university and biotechnology industry collaborations.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0239035
Funder
Australian Research Council
Funding Amount
$900,000.00
Summary
Regional facility for surface and micro-structure analysis. Adelaide, Flinders and SA Universities seek to enhance the regional facility for surface and microstructure analysis. Equipment includes electron back scatter pattern imaging, high resolution coater, microprobe (CAMECA SX51) upgrade and X ray microtomography to be located at Adelaide University Centre for Electron Microscopy and Microstructure Analysis, the hub of the regional facility. The University of South Australia Ian Wark Researc ....Regional facility for surface and micro-structure analysis. Adelaide, Flinders and SA Universities seek to enhance the regional facility for surface and microstructure analysis. Equipment includes electron back scatter pattern imaging, high resolution coater, microprobe (CAMECA SX51) upgrade and X ray microtomography to be located at Adelaide University Centre for Electron Microscopy and Microstructure Analysis, the hub of the regional facility. The University of South Australia Ian Wark Research Institute node will house ToF-SIMS and SAM upgrades, the Flinders node a multimode STM atomic force microscope, and the Adelaide University Waite Campus node confocal xyz control and digital camera. Applications include biological, materials and geological research projects.Read moreRead less