Australian Laureate Fellowships - Grant ID: FL120100030
Funder
Australian Research Council
Funding Amount
$2,779,572.00
Summary
Engineering materials for advances in nanomedicine. Nanomedicine is one of the fastest growing areas in nanotechnology. This project will develop next-generation particle systems with engineered properties that are expected to underpin advances in the delivery of therapeutics in the areas of cancer, vaccines, cardiovascular disease and neural health.
Discovery Early Career Researcher Award - Grant ID: DE230101542
Funder
Australian Research Council
Funding Amount
$450,154.00
Summary
Impact of humoral immunity on nanoparticle–biological interactions. This project aims to improve the biological applications of nanomaterials by understanding their fundamental interactions with proteins and cells in relevant biological environments. This will create new knowledge on how humoral (antibody-mediated) immunity affects nanomaterials using cutting-edge immunoassays, bio–nano characterisation techniques, and bioinformatics. Expected outcomes of the project include an understanding of ....Impact of humoral immunity on nanoparticle–biological interactions. This project aims to improve the biological applications of nanomaterials by understanding their fundamental interactions with proteins and cells in relevant biological environments. This will create new knowledge on how humoral (antibody-mediated) immunity affects nanomaterials using cutting-edge immunoassays, bio–nano characterisation techniques, and bioinformatics. Expected outcomes of the project include an understanding of how specific antibodies modulate the protein coatings on nanomaterials, which will shed light on how immune cells interact with nanomaterials. This will lead to design principles for nanomaterial properties to improve their effectiveness in delivering drugs and gene therapies.Read moreRead less
Hybrid diamond materials for next generation sensing, biodiagnostic and quantum devices. Nanodiamond mixed with non-diamond materials will revolutionise quantum-photonic devices spawning a step change in nanoscale bio-chemical and remote sensing. The outcomes of this work will have a significant impact on the prognosis of diseases, security, and communications and will enhance Australia's reputation as a world leader in nano-materials.
Nanoengineered Polymeric Materials for Environmental and Biological Applications. The development of advanced materials with nanoengineered properties promises to revolutionise future industries, including the energy and healthcare sectors. This research program will involve the design, synthesis and assembly of tailored polymers to prepare next-generation, engineered materials. The research will deliver advanced polymeric membranes, tissue engineering scaffolds and vaccine delivery systems. The ....Nanoengineered Polymeric Materials for Environmental and Biological Applications. The development of advanced materials with nanoengineered properties promises to revolutionise future industries, including the energy and healthcare sectors. This research program will involve the design, synthesis and assembly of tailored polymers to prepare next-generation, engineered materials. The research will deliver advanced polymeric membranes, tissue engineering scaffolds and vaccine delivery systems. These materials are expected to provide benefits for Australian citizens in the energy and health sectors and contribute to the development of a robust Australian nanotechnology industry. The projects will also provide opportunities for the development of outstanding young scientists and will foster multidisciplinary collaborations.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100163
Funder
Australian Research Council
Funding Amount
$639,369.00
Summary
Nano-bioscience imaging facility. This project aims to investigate the interactions between nano-engineered materials and biological systems through the use of cutting-edge imaging technologies. The project will consist of an ImageStreamX Imaging Flow Cytometer and a Coherent Anti-Stokes Raman Scattering Microscope. Together these will allow high throughput and label-free imaging of cell-nanomaterial interactions, which will underpin research by leading researchers as well as promoting collabora ....Nano-bioscience imaging facility. This project aims to investigate the interactions between nano-engineered materials and biological systems through the use of cutting-edge imaging technologies. The project will consist of an ImageStreamX Imaging Flow Cytometer and a Coherent Anti-Stokes Raman Scattering Microscope. Together these will allow high throughput and label-free imaging of cell-nanomaterial interactions, which will underpin research by leading researchers as well as promoting collaborations between researchers in the physical and life sciences. This will provide significant benefits, such as the development of new materials for potential applications in nano-bioscience.Read moreRead less
Multifunctional particles for biological applications. This project aims to engineer multifunctional particles, examine their biological interactions and create particles for cell targeting, cell internalisation, subcellular drug release and improved pharmacokinetics. Engineered particles are important for drug delivery in nanomedicine. Although various particle-based delivery systems have been developed, few have been commercialised, largely because of problems challenges associated with biolog ....Multifunctional particles for biological applications. This project aims to engineer multifunctional particles, examine their biological interactions and create particles for cell targeting, cell internalisation, subcellular drug release and improved pharmacokinetics. Engineered particles are important for drug delivery in nanomedicine. Although various particle-based delivery systems have been developed, few have been commercialised, largely because of problems challenges associated with biological barriers. This project will develop a platform for the assemble of particles with tailored properties which are expected to provide insights on particle-biological interactions for particle-based therapeutic delivery.Read moreRead less
Establishing nanoscale design principles for non-viral genome engineering. This project aims to develop a bio-nanotechnology platform for non-viral genome engineering using dendronised polymers. The project will advance both fundamental and practical knowledge at the forefront of nanotechnology and cell biology, whilst providing training to the research community. Outcomes from the project will also provide significant benefits, such as positioning Australia at the forefront of genome engineerin ....Establishing nanoscale design principles for non-viral genome engineering. This project aims to develop a bio-nanotechnology platform for non-viral genome engineering using dendronised polymers. The project will advance both fundamental and practical knowledge at the forefront of nanotechnology and cell biology, whilst providing training to the research community. Outcomes from the project will also provide significant benefits, such as positioning Australia at the forefront of genome engineering.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100279
Funder
Australian Research Council
Funding Amount
$424,198.00
Summary
A nanodiamond voltage sensor: towards real-time, long-term neuronal sensing. This project aims to develop a voltage sensor that may ultimately be used to measure neuronal signals noninvasively in real-time and over hours. The project expects to generate the fundamental science needed to use nanodiamonds for fluorescence-based voltage sensing that can be easily measured using optical microscopy. The expected outcome is a biocompatible sensor that should provide a solution to one of the biggest ch ....A nanodiamond voltage sensor: towards real-time, long-term neuronal sensing. This project aims to develop a voltage sensor that may ultimately be used to measure neuronal signals noninvasively in real-time and over hours. The project expects to generate the fundamental science needed to use nanodiamonds for fluorescence-based voltage sensing that can be easily measured using optical microscopy. The expected outcome is a biocompatible sensor that should provide a solution to one of the biggest challenges in neuroscience; the fast, precise and long-term measurement of neuronal activity. This technology may one day inform our understanding of how the normal brain works and provide major insights into mental health conditions and neurodegenerative diseases.Read moreRead less
Bespoke nanomaterials for understanding nano-bio interactions under flow. This project aims to develop innovative scalable synthesis techniques to produce polymeric nanomaterials with controlled properties and characterise interactions between nanomaterials and cells under flow conditions. This project expects to generate new knowledge in priority research areas of nanotechnology, polymer chemistry and immunology. The outcome of this project is an original scalable and environmentally friendly t ....Bespoke nanomaterials for understanding nano-bio interactions under flow. This project aims to develop innovative scalable synthesis techniques to produce polymeric nanomaterials with controlled properties and characterise interactions between nanomaterials and cells under flow conditions. This project expects to generate new knowledge in priority research areas of nanotechnology, polymer chemistry and immunology. The outcome of this project is an original scalable and environmentally friendly technology, new knowledge of cell-nanomaterial interactions and new design principles for nanoparticles with potential future applications in drug delivery, immunology and nanomedicine. This project should provide significant benefits to polymer, nanomaterial and pharmaceutical research and industry in Australia.Read moreRead less
Engineering nanoscale tools for cellular interrogation. The aim is to address fundamental hurdles to engineering seamless nanobiointerfaces between electroactive nanoscale tools and living cells. This is expected to allow efficient delivery of many bioactive cargo types into cells, intracellular sampling of cytosol contents, and probing of action potential, all at the cell—material interface. New, powerful, electroactive nanoscale tools that deliver precise spatio-temporal resolution and minimal ....Engineering nanoscale tools for cellular interrogation. The aim is to address fundamental hurdles to engineering seamless nanobiointerfaces between electroactive nanoscale tools and living cells. This is expected to allow efficient delivery of many bioactive cargo types into cells, intracellular sampling of cytosol contents, and probing of action potential, all at the cell—material interface. New, powerful, electroactive nanoscale tools that deliver precise spatio-temporal resolution and minimal invasiveness and perturbation are likely to transform ex-vivo cellular processes. The intended outcomes are crucial for maximising precision in engineering and implementing of ex-vivo cellular processes. Fundamental advances in knowledge may eventually be a platform for developing cell-based therapies.
Read moreRead less