Acute Alerting Effects Of Daytime Exposure To Specific Wavelengths Of Light
Funder
National Health and Medical Research Council
Funding Amount
$446,367.00
Summary
Excessive sleepiness is the greatest identifiable and preventable cause of accidents in all modes of transportation. Shift workers working outside the 8am-5pm day, make up about 20% of the urban working population. These individuals often report excessive daytime sleepiness caused by irregular sleep-wake patterns and long-term sleep loss. Excessive sleepiness is also common in individuals with sleep disorders. While there are many stimulant and wake-promoting drugs available to counteract daytim ....Excessive sleepiness is the greatest identifiable and preventable cause of accidents in all modes of transportation. Shift workers working outside the 8am-5pm day, make up about 20% of the urban working population. These individuals often report excessive daytime sleepiness caused by irregular sleep-wake patterns and long-term sleep loss. Excessive sleepiness is also common in individuals with sleep disorders. While there are many stimulant and wake-promoting drugs available to counteract daytime fatigue such drugs have problems of side effects, interactions and in some cases dependence. Light has many beneficial effects for a wide range of medicinal, physiological, psychological, and social purposes. One well known effect is as a stimulant so that exposure to bright light, both during the night and in the middle of the day, improves alertness and attention, and decreases reaction times thus improving performance. These effects can also be measured as changes in brain activity. However we do not understand the mechanisms in the eyes which control these effects. While certain cells in the eyes called rods and cones are necessary for seeing objects clearly and for detecting colour, there appears to be another system in the eyes which may involve different specialized cells or photoreceptors that are important for the alerting effects of light. White light is made up of different wavelengths or colours of light. This study will examine which wavelength (blue, violet, red or green) of light best improves alertness and learning during the daytime. Various performance tests will be used in addition to measures of brain wave activity. By identifying the most effective wavelength of light for improving alertness in healthy young adults and better understanding the mechanisms in the eyes involved, we will be able to develop light treatment strategies in patient groups with sleep disorders and in individuals like shift workers who experience sleep loss.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100741
Funder
Australian Research Council
Funding Amount
$342,996.00
Summary
Harnessing neural plasticity with brain stimulation. This project aims to investigate the links between the molecular mechanisms underlying brain plasticity and the effects of non-invasive brain stimulation. It will use a novel approach that integrates genetics, electrophysiology and biological modelling. Plasticity underpins all learning, memory and aging. Brain stimulation can drive plasticity in humans, but these effects are extremely difficult to harness and vary widely between people. Expec ....Harnessing neural plasticity with brain stimulation. This project aims to investigate the links between the molecular mechanisms underlying brain plasticity and the effects of non-invasive brain stimulation. It will use a novel approach that integrates genetics, electrophysiology and biological modelling. Plasticity underpins all learning, memory and aging. Brain stimulation can drive plasticity in humans, but these effects are extremely difficult to harness and vary widely between people. Expected outcomes include a critical understanding of the fundamental mechanisms governing plasticity. This will provide significant benefits such as the development of individually optimised brain stimulation protocols, enabling tailored, reliable approaches to address brain function and cognition.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100694
Funder
Australian Research Council
Funding Amount
$372,014.00
Summary
Does disconnection in the aging brain cause age-related movement decline? This project aims to use new neurophysiological approaches to understand the causal role of age-related changes in brain network connectivity to the movement control. Brain regions interact through complex and dynamic neural networks to control voluntary movement, but whether age-related changes in network connectivity drive age-related decline in movement control is unknown. This project will provide significant benefits ....Does disconnection in the aging brain cause age-related movement decline? This project aims to use new neurophysiological approaches to understand the causal role of age-related changes in brain network connectivity to the movement control. Brain regions interact through complex and dynamic neural networks to control voluntary movement, but whether age-related changes in network connectivity drive age-related decline in movement control is unknown. This project will provide significant benefits such as the neurophysiological knowledge required to develop targeted interventions to improve movement control in the aging population.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100575
Funder
Australian Research Council
Funding Amount
$423,604.00
Summary
Does neuroplasticity protect against late life cognitive impairment? This project aims to investigate neuroplasticity across the adult lifespan, using novel neurophysiological approaches to determine its role in protecting against age-related cognitive decline. This project expects to generate new knowledge in the area of human cognitive ageing, using an innovative and interdisciplinary approach. Expected outcomes of this project include a critical understanding of the basic neural mechanisms of ....Does neuroplasticity protect against late life cognitive impairment? This project aims to investigate neuroplasticity across the adult lifespan, using novel neurophysiological approaches to determine its role in protecting against age-related cognitive decline. This project expects to generate new knowledge in the area of human cognitive ageing, using an innovative and interdisciplinary approach. Expected outcomes of this project include a critical understanding of the basic neural mechanisms of healthy brain ageing. This will provide significant benefits, such as the neurophysiological knowledge required to develop novel biological markers to detect, as well as therapeutic agents to curb, cognitive decline in the aging population.Read moreRead less
Understanding working memory: from cells to brain stimulation. This project aims to understand the neural mechanisms of working memory, a fundamental cognitive function in humans, using a novel framework which combines non-invasive brain stimulation, neuroimaging, pharmacological and experimental manipulations, and biological modelling. Expected outcomes include a critical understanding of the cellular mechanisms underlying both neural activity and working memory ability in healthy individuals a ....Understanding working memory: from cells to brain stimulation. This project aims to understand the neural mechanisms of working memory, a fundamental cognitive function in humans, using a novel framework which combines non-invasive brain stimulation, neuroimaging, pharmacological and experimental manipulations, and biological modelling. Expected outcomes include a critical understanding of the cellular mechanisms underlying both neural activity and working memory ability in healthy individuals and a detailed knowledge of how to non-invasively interact with these mechanisms using brain stimulation. This will provide significant benefits such as the development of individually optimised brain stimulation protocols, enabling tailored approaches to reliably alter brain function and cognition.Read moreRead less
Testing the ghost with the machine: Empirical investigations of cognition using high-field functional magnetic resonance imaging. The primary aim of the project is to test hypotheses about the cognitive architecture of word production and negative priming using high-field functional magnetic resonance imaging (fMRI). Additional aims/outcomes are to apply a novel fMRI acquisition sequence that permits overt verbal responding with rapid presentation of trials and collection of the time course of t ....Testing the ghost with the machine: Empirical investigations of cognition using high-field functional magnetic resonance imaging. The primary aim of the project is to test hypotheses about the cognitive architecture of word production and negative priming using high-field functional magnetic resonance imaging (fMRI). Additional aims/outcomes are to apply a novel fMRI acquisition sequence that permits overt verbal responding with rapid presentation of trials and collection of the time course of the blood oxygen level dependent (BOLD) signal, and to further develop a methodology that delineates the logic of making inferences about cognitive systems from functional neuroimaging data. These represent potentially significant developments in the fields of cognitive neuroscience and functional neuroimaging.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160101102
Funder
Australian Research Council
Funding Amount
$378,536.00
Summary
Memory Engram Storage and Retrieval. This project aims to probe how long-term memory is stored in the brain. Recently, memory engram-labelling technology has revolutionised the way memory can be experimentally studied. It is now known that sparse populations of neurons that were active during a defined training window are both sufficient and necessary for retrieval of specific memories, and that activation of hippocampal engram causes further downstream activity in connected engram cells of othe ....Memory Engram Storage and Retrieval. This project aims to probe how long-term memory is stored in the brain. Recently, memory engram-labelling technology has revolutionised the way memory can be experimentally studied. It is now known that sparse populations of neurons that were active during a defined training window are both sufficient and necessary for retrieval of specific memories, and that activation of hippocampal engram causes further downstream activity in connected engram cells of other brain regions. However, it is unknown whether engram cell connectivity is important for memory function. The project aims to test this question. Understanding more about memory function in normal conditions may help us to understand and treat disorders of memory.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200101708
Funder
Australian Research Council
Funding Amount
$406,821.00
Summary
New directions for using brain stimulation to understand brain function. Neuroplasticity is of fundamental importance to brain function as it mediates learning, memory and development. Deficits in neuroplasticity are observed in a number of neurological conditions and thought to contribute to cognitive dysfunction. This study is designed to develop a better understanding of the neurochemical and genetic factors impacting on neuroplasticity. In addition, it aims to (i) upregulate brain connectivi ....New directions for using brain stimulation to understand brain function. Neuroplasticity is of fundamental importance to brain function as it mediates learning, memory and development. Deficits in neuroplasticity are observed in a number of neurological conditions and thought to contribute to cognitive dysfunction. This study is designed to develop a better understanding of the neurochemical and genetic factors impacting on neuroplasticity. In addition, it aims to (i) upregulate brain connectivity in a precise and targeted manner, (ii) elicit functional increases in cognitive performance and (iii) demonstrate the relationship between functional connectivity and cognition. Outcomes include a better understanding of plasticity in the brain & a enhanced capacity to examine and modulate brain plasticity.Read moreRead less
Testing posterior parietal cortex contributions to human episodic memory. This project aims to determine the involvement of parietal brain regions for episodic memory. Using novel experimental tasks and multimodal neuroimaging techniques in young and healthy aging, this project expects to clarify the role of posterior parietal structures, and their interactions with core memory structures, during memory retrieval. Expected outcomes include advanced understanding of how we remember the past in ri ....Testing posterior parietal cortex contributions to human episodic memory. This project aims to determine the involvement of parietal brain regions for episodic memory. Using novel experimental tasks and multimodal neuroimaging techniques in young and healthy aging, this project expects to clarify the role of posterior parietal structures, and their interactions with core memory structures, during memory retrieval. Expected outcomes include advanced understanding of how we remember the past in rich contextual detail, and how such processes are altered in healthy aging. This potentially provides significant benefits in predicting and treating memory dysfunction due to brain injury or neurodegeneration.Read moreRead less
Human hippocampus subregions organisation and associative memory processes. This proposal will investigate the hippocampus, a highly inter-connected structure containing many subregions. Although considered the memory centre of the brain, we still do not know the exact roles of these subregions during memory processes. Using novel brain neuroimaging acquisition methods and analyses, this project aims to map the internal structure and functions of the hippocampus and its functional networks under ....Human hippocampus subregions organisation and associative memory processes. This proposal will investigate the hippocampus, a highly inter-connected structure containing many subregions. Although considered the memory centre of the brain, we still do not know the exact roles of these subregions during memory processes. Using novel brain neuroimaging acquisition methods and analyses, this project aims to map the internal structure and functions of the hippocampus and its functional networks under different memory conditions and how these functions change with age. The intended outcome of this proposal is to provide the foundations for the first integrated model of human memory and its biological basis and to generate a benchmark against which future development of memory interventions and retraining can be measured.Read moreRead less