Paving the way for ultra-long haul flights: strategies to mitigate jetlag. This project aims to develop and test strategies to mitigate jetlag, founded on biophysical modelling of circadian rhythms. It sets out to quantify the speed of circadian adaptation of sleep, alertness, and metabolism after transmeridian travel and to maximise speed of adaptation via optimised timing of light exposure, food, and exercise in-flight and on-the-ground. Expected outcomes include powerful models for jetlag str ....Paving the way for ultra-long haul flights: strategies to mitigate jetlag. This project aims to develop and test strategies to mitigate jetlag, founded on biophysical modelling of circadian rhythms. It sets out to quantify the speed of circadian adaptation of sleep, alertness, and metabolism after transmeridian travel and to maximise speed of adaptation via optimised timing of light exposure, food, and exercise in-flight and on-the-ground. Expected outcomes include powerful models for jetlag strategies, ready for application in air travel. The project will directly inform Qantas’ operations for ultra-long haul flights and their international network more broadly. Project outcomes will benefit society and the economy through improving travellers’ alertness, sleep, and reducing the risk of fatigue-related accidents.Read moreRead less
Targeted isolation of specific marine bacterial species associated with higher organsims for the purpose of discovering new antimicrobial compounds. Specific bacterial species that are commonly found in association with marine plants and animals often produce active secondary metabolites. The aim of this project is to apply our understanding of these bacterial-host associations to the targeted isolation of novel antimicrobials from the marine environment. While these new compounds will undoubted ....Targeted isolation of specific marine bacterial species associated with higher organsims for the purpose of discovering new antimicrobial compounds. Specific bacterial species that are commonly found in association with marine plants and animals often produce active secondary metabolites. The aim of this project is to apply our understanding of these bacterial-host associations to the targeted isolation of novel antimicrobials from the marine environment. While these new compounds will undoubtedly have a number of commercial applications this project focuses on the development of products for dental hygiene in animals. Generally, the urgent need for new antimicrobial compounds to combat the growing number of microbes that are resistant to current antibiotics highlights the importance of this project.Read moreRead less
Frayed at the edges? Integrating evolutionary genetics into the study of species distributional limits. Restricted species, like those in rainforests, represent the vast majority of biodiversity, but they face high risks of extinction due to climate change unless they can adapt. Using butterflies as a model, this project will examine whether rainforest restricted species are able to adapt to future climate change and provide insight into their extinction risk.
ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems. ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems. The ARC Centre for the Mathematical Analysis of Cellular Systems aims to deliver the mathematics required to compute life. The Centre will deliver innovation in computational and mathematical biology and establish in silico biology alongside in vivo and in vitro biology. These models will allow us to understand the complexity of life at the cellu ....ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems. ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems. The ARC Centre for the Mathematical Analysis of Cellular Systems aims to deliver the mathematics required to compute life. The Centre will deliver innovation in computational and mathematical biology and establish in silico biology alongside in vivo and in vitro biology. These models will allow us to understand the complexity of life at the cellular level and enable new ways of combining diverse and heterogenous data. This will allow us to understand the mechanisms underlying cellular behaviour, and to apply rational design engineering methods in order to control the dynamics of biological systems. Read moreRead less
Neural circuit control of effort under stress . This Project aims to investigate how the ‘decision’ to persist in exerting effort to obtain a reward is encoded in the the brain and affected by stress. This work will generate new knowledge on the neural mechanisms through which stress modifies neural activity to control decision making processes underpinning adaptive behaviours essential for survival. The expected outcomes of this work include enhanced capacity at the interface of behavioural a ....Neural circuit control of effort under stress . This Project aims to investigate how the ‘decision’ to persist in exerting effort to obtain a reward is encoded in the the brain and affected by stress. This work will generate new knowledge on the neural mechanisms through which stress modifies neural activity to control decision making processes underpinning adaptive behaviours essential for survival. The expected outcomes of this work include enhanced capacity at the interface of behavioural and computational neuroscience, that will in turn provide significant benefits through greater insight into brain functions essential for survival, with long ranging implications for performance optimisation and brain-inspired computing. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100016
Funder
Australian Research Council
Funding Amount
$850,000.00
Summary
A collaborative electron microscopy network for structural biology. This project aims to establish a high-throughput pipeline to determine the near-atomic-resolution structure of proteins by cryo-electron microscopy (cryo-EM). Over the past five years, cryo-EM has improved the study of biological macromolecules at near-atomic resolution. This project will use two automated electron microscopes and a Titan Krios microscope to build a world-competitive integrated cryo-EM network for structural bio ....A collaborative electron microscopy network for structural biology. This project aims to establish a high-throughput pipeline to determine the near-atomic-resolution structure of proteins by cryo-electron microscopy (cryo-EM). Over the past five years, cryo-EM has improved the study of biological macromolecules at near-atomic resolution. This project will use two automated electron microscopes and a Titan Krios microscope to build a world-competitive integrated cryo-EM network for structural biology. This research is expected to increase the understanding of molecular events that are central for life.Read moreRead less
The sparrows in the mining towns: a century of adaptation to contamination. Our research will characterise how contamination from the extraction of precious metals can spread through the environment and how it effects a highly urbanised bird – the house sparrow. In many cases, populations of these birds have been intimately associated with mining operations for over a century, and our recent work has provided evidence of adaptation over time. House sparrows provide a great natural system to unde ....The sparrows in the mining towns: a century of adaptation to contamination. Our research will characterise how contamination from the extraction of precious metals can spread through the environment and how it effects a highly urbanised bird – the house sparrow. In many cases, populations of these birds have been intimately associated with mining operations for over a century, and our recent work has provided evidence of adaptation over time. House sparrows provide a great natural system to understand the genetic potential of organisms to adapt to anthropomorphic change in the environment connected with the resources industry. Our work, will bring new insight into the future management of environmental contamination, and the mitigation of adverse effects arising from resource extraction.Read moreRead less
Special Research Initiatives - Grant ID: SR0354636
Funder
Australian Research Council
Funding Amount
$30,000.00
Summary
Australian Computational Molecular Science Network. Computational Molecular Science (CMS) involves the use of theory and computational methods to simulate and visualise molecular systems ranging from small atmospheric species to proteins, nucleic acids, chemical polymers and materials. It represents our most incisive expression of what we understand about the molecular basis of nature. The CMS network will integrate and cross-fertilize both fundamental and application-based expertize in molecula ....Australian Computational Molecular Science Network. Computational Molecular Science (CMS) involves the use of theory and computational methods to simulate and visualise molecular systems ranging from small atmospheric species to proteins, nucleic acids, chemical polymers and materials. It represents our most incisive expression of what we understand about the molecular basis of nature. The CMS network will integrate and cross-fertilize both fundamental and application-based expertize in molecular scale computations in the fields of nanoscience, biomaterials, biotechnology, biomedical science and environmental science. It will uncover and explore critical new interdisciplinary science and create new molecular-based paradigms that will drive advances in these fields over the next decade.Read moreRead less
ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the ....ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the whole genome as large inserts in BAC vectors, and build a "golden path" with minimal overlap. We will construct libraries of expressed genes from tammar tissues and array them for use in analysing gene expression.Read moreRead less
Characterisation of tumour variants of Devil Facial Tumour Disease. This project will take a new approach to cancer research by studying the evolution of Devil Facial Tumour Disease. The results will directly contribute to the conservation management of the Tasmanian devil, as well as generating new information on tumour growth, metastasis and emergence of resistance.