Elucidating structure and function of activation-associated secreted proteins (ASPs) in blood-feeding hookworms – toward new methods of control. The national/community benefits are: (1) to develop a long-term, high quality scientific and technological program contributing to national objectives, including the maintenance of a strong capability in basic research, the development of new scientific concepts and the enhancement of international collaborative links; (2) to strengthen the links betwee ....Elucidating structure and function of activation-associated secreted proteins (ASPs) in blood-feeding hookworms – toward new methods of control. The national/community benefits are: (1) to develop a long-term, high quality scientific and technological program contributing to national objectives, including the maintenance of a strong capability in basic research, the development of new scientific concepts and the enhancement of international collaborative links; (2) to strengthen the links between basic and applied research; (3) to develop excellence in research by promoting collaborative research, resulting in a more efficient use of resources in a national and international context; (4) to enhance the skills-base in biology and biotechnology; (5) to substantially increase global visibility through quality research, leading to an increased investment in Australian science.Read moreRead less
Mitogenomics using a massively parallel reactor platform - from barcoding to diagnostic tools for pathogens of major socioeconomic importance. The national/community benefits are: (1) to develop a long-term, high quality scientific and technological program contributing to national objectives, including the maintenance of a strong capability in basic research, the development of new scientific concepts and the enhancement of international collaborative links; (2) to strengthen the links between ....Mitogenomics using a massively parallel reactor platform - from barcoding to diagnostic tools for pathogens of major socioeconomic importance. The national/community benefits are: (1) to develop a long-term, high quality scientific and technological program contributing to national objectives, including the maintenance of a strong capability in basic research, the development of new scientific concepts and the enhancement of international collaborative links; (2) to strengthen the links between basic and applied research; (3) to develop excellence in research by promoting collaborative research, resulting in a more efficient use of resources in a national and international context; (4) to enhance the skills-base in biology and biotechnology; (5) to substantially increase global visibility through quality research, leading to an increased investment in Australian science.
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Who were the ancestors of Homo floresiensis? The discovery of a tiny, new hominid species living in Indonesia until just 12,000 years ago, at the same time as modern humans in the region, has sparked world-wide public interest and debate. Finding the ancestors of this species will further promote Australian research as high profile, high calibre and cutting edge. Collaboration with researchers and institutions in Indonesia, USA, Kenya, Tanzania, South Africa and the Republic of Georgia will stre ....Who were the ancestors of Homo floresiensis? The discovery of a tiny, new hominid species living in Indonesia until just 12,000 years ago, at the same time as modern humans in the region, has sparked world-wide public interest and debate. Finding the ancestors of this species will further promote Australian research as high profile, high calibre and cutting edge. Collaboration with researchers and institutions in Indonesia, USA, Kenya, Tanzania, South Africa and the Republic of Georgia will strengthen our links with these nations.Read moreRead less
Mass Spectrometric Investigations of Conformation and Dynamics of Biological Complexes. The new collaboration between the leading mass spectrometry groups at University Wollongong and Cambridge University will benefit both partners. Researchers at Wollongong will have access to an ion mobility mass spectrometry technology not currently available in Australia that will contribute to our understanding of complicated cellular processes such as chromosome replication. The researchers' experience wit ....Mass Spectrometric Investigations of Conformation and Dynamics of Biological Complexes. The new collaboration between the leading mass spectrometry groups at University Wollongong and Cambridge University will benefit both partners. Researchers at Wollongong will have access to an ion mobility mass spectrometry technology not currently available in Australia that will contribute to our understanding of complicated cellular processes such as chromosome replication. The researchers' experience with this technology will pave the way for introduction of the technology to Australia and benefit the wider scientific community in wide-ranging projects such as development of new antibiotics and vaccines. Students from both institutions will benefit from experiencing science from an international perspective.Read moreRead less
Alternative Splicing in the Mouse Transcriptome. Although the human genome completion is cause for excitement we do not have any firm indication of precisely how many protein-coding genes exist in a mammalian genome. We have even less indication of the extent to which these genes generate alternative gene products, through a process termed alternative splicing. The detection and sequencing of these full-length alternative gene products is the focus of this application. This application details t ....Alternative Splicing in the Mouse Transcriptome. Although the human genome completion is cause for excitement we do not have any firm indication of precisely how many protein-coding genes exist in a mammalian genome. We have even less indication of the extent to which these genes generate alternative gene products, through a process termed alternative splicing. The detection and sequencing of these full-length alternative gene products is the focus of this application. This application details the opportunity to participate in the identification of the full transcriptome of the mouse and is part of a collaborative effort with The RIKEN Genome Sciences Center in Japan.Read moreRead less
Harnessing next-generation technologies to tackle major food-borne parasites and design new interventions. Frontier technologies will be used in this project to unlock the molecular secrets of parasites which cause serious food-borne diseases in animals. The quantum leap made here will lead to radically new ways of treating and controlling such diseases, and provide outstanding international visibility of Australian science and a solid skills/knowledge-base.
SCP/TAPS proteins of the barber’s pole worm. This integrated, collaborative project, will explore, in a targeted way, the structure and function of a key group of molecules in a socio-economically important eukaryotic pathogen and their involvement in pathogen-host interactions. Fundamental knowledge and understanding of these molecules will provide a solid foundation for understanding disease processes and finding new intervention strategies for a range of pathogens. This is crucial, given the ....SCP/TAPS proteins of the barber’s pole worm. This integrated, collaborative project, will explore, in a targeted way, the structure and function of a key group of molecules in a socio-economically important eukaryotic pathogen and their involvement in pathogen-host interactions. Fundamental knowledge and understanding of these molecules will provide a solid foundation for understanding disease processes and finding new intervention strategies for a range of pathogens. This is crucial, given the serious drug resistance problems in pathogens, and residue problems in meat, milk and the environment.Read moreRead less
Managing microorganisms in Melbourne’s drinking water assets. Safe, fresh drinking water is the most important resource of any country. Melbourne Water Corporation supplies drinking water to more than four million people, and Melbourne is one of the few cities in the world that receives largely unfiltered drinking water from wilderness catchment areas. Built on extensive preliminary collaborative work, the project aims to develop an integrated monitoring and surveillance program, using newly dev ....Managing microorganisms in Melbourne’s drinking water assets. Safe, fresh drinking water is the most important resource of any country. Melbourne Water Corporation supplies drinking water to more than four million people, and Melbourne is one of the few cities in the world that receives largely unfiltered drinking water from wilderness catchment areas. Built on extensive preliminary collaborative work, the project aims to develop an integrated monitoring and surveillance program, using newly developed technologies, to underpin Melbourne Water Corporation’s prevention strategy against key waterborne diseases, including cryptosporidiosis and giardiasis. This project is sharply focused on the National Science and Research Priorities 'Soil and Water', 'Environmental Change' and 'Health'.Read moreRead less