Early Childhood Caries: A Longitudinal Study Measuring The Risk And Protective Factors In Infants 1-18 Months Of Age
Funder
National Health and Medical Research Council
Funding Amount
$123,736.00
Summary
Dental decay affects 70% of Australian children, with children in rural areas being worse off. This study will describe the natural history of dental decay from birth to 18 months and will examine the environment, behaviours and biology that these infants are exposed to over time. Although families will benefit most from this research, the study contributes uniquely to our knowledge of decay in young children and will directly inform population health and targeted programs of care.
MicroRNA Expression Profiling Of Eutopic Endometrium In Women With Versus Without Endometriosis
Funder
National Health and Medical Research Council
Funding Amount
$224,211.00
Summary
Endometriosis is a medical condition where endometrium grows outside the womb. About 10% of women have this condition that can cause abdominal pain, painful periods and difficulty conceiving a child. Now endometriosis can only be diagnosed by surgical procedure. We believe that the presence of endometriosis causes particular small molecules called microRNAs to be present in the lining of the womb or in the blood only in women with endometriosis, and we could develop a test for endometriosis with ....Endometriosis is a medical condition where endometrium grows outside the womb. About 10% of women have this condition that can cause abdominal pain, painful periods and difficulty conceiving a child. Now endometriosis can only be diagnosed by surgical procedure. We believe that the presence of endometriosis causes particular small molecules called microRNAs to be present in the lining of the womb or in the blood only in women with endometriosis, and we could develop a test for endometriosis without resorting to surgery.Read moreRead less
Improving Treatment Outcomes For Malignant Mesothelioma Patients Using Biomarkers.
Funder
National Health and Medical Research Council
Funding Amount
$795,262.00
Summary
The deadly asbestos-induced cancer mesothelioma is continuing to kill tens of thousands of people each year. Most patients are diagnosed with advanced disease. In this study we will use novel biomarkers to help the diagnosis of mesothelioma and potentially improve treatment options for patients.
Biomarkers For The Diagnosis Of Childhood TB: Validation In A High TB Prevalence Setting
Funder
National Health and Medical Research Council
Funding Amount
$948,086.00
Summary
The WHO highlights the urgent need for new diagnostic tests to combat the global TB pandemic. Diagnosis of TB is particularly difficult in children. In our previous NHMRC-funded Melbourne-based study we found promising diagnostic markers in blood which can differentiate patients with and without TB. This project has the potential to revolutionise the diagnosis of TB by providing data that will enable the development of a new generation of diagnostic tests.
Tackling Key Epidemiological And Basic Scientific Research Issues In Prion Diseases.
Funder
National Health and Medical Research Council
Funding Amount
$401,109.00
Summary
Proposed Practitioner Fellowship research will simultaneously include epidemiological and basic scientific projects, emphasising human prion disease. Epidemiological research will involve large-scale studies to clarify genetic factors that influence susceptibility to developing prion disease, as well as clarify whether Alzheimer disease is transmissible, while basic scientific research will include determining the characteristics of the misfolded prion proteins causing neuronal disease.
Defining The Role Of MiR-146a In Human Hendra Virus Infections
Funder
National Health and Medical Research Council
Funding Amount
$348,998.00
Summary
This project aims to improve the medical management of people infected with Hendra virus by defining potential therapeutic windows for treatment with antiviral strategies. The project involves the study of microRNAs, a class of small ribonucleic acid molecules that regulate biological processes in eukaryotes. We will determine the role of microRNAs in the Hendra virus infection process in humans, and their application as diagnostic markers of Hendra virus infection.
Screening For Recently Defined Genetic Lesions In Poor Risk Adult And Childhood ALL, And Developing Treatment Approaches To Target Causative Pathways.
Funder
National Health and Medical Research Council
Funding Amount
$744,938.00
Summary
Most adults and 20% of children with ALL relapse and die of their disease. Chromosomal changes resulting in the formation of new proteins have been recently identified in a significant number of cases. Importantly, drugs targeting these proteins are in clinical practice for other diseases. We will develop new tests to rapidly identify these patients at diagnosis, and assess the efficacy of adding these drugs to first line treatment in a clinical trial. The outcome for these patients will likely ....Most adults and 20% of children with ALL relapse and die of their disease. Chromosomal changes resulting in the formation of new proteins have been recently identified in a significant number of cases. Importantly, drugs targeting these proteins are in clinical practice for other diseases. We will develop new tests to rapidly identify these patients at diagnosis, and assess the efficacy of adding these drugs to first line treatment in a clinical trial. The outcome for these patients will likely improve significantly using this approachRead moreRead less