Multimodal biomedical imaging probes: development of advanced polymer nanocomposite devices for oncology. Despite significant research being directed toward cancer treatment, 7.6 million people died world wide in 2007. Early detection and treatment is widely recognised as being effective in significantly reducing mortality rates. Biomedical imaging techniques are routinely used for detection and staging of many cancers. However, greater sensitivity is required so that these techniques can be app ....Multimodal biomedical imaging probes: development of advanced polymer nanocomposite devices for oncology. Despite significant research being directed toward cancer treatment, 7.6 million people died world wide in 2007. Early detection and treatment is widely recognised as being effective in significantly reducing mortality rates. Biomedical imaging techniques are routinely used for detection and staging of many cancers. However, greater sensitivity is required so that these techniques can be applied to very early detection of tumours. To overcome this short-coming the next generation of imaging probes will be developed, which will require fundamental investigations in polymer and nanomaterials science to maximise imaging sensitivity and extend probe functionality. Successful outcomes will lead to significant benefits to healthcare in Australia.Read moreRead less
Probing the function of protein molecular motors on nano-fabricated structures. The function of protein linear molecular motors, which are natural dynamic bio-nano-devices with a ubiquitous importance in multicellular organisms, will be 'probed' with purposefully designed nano-structures fabricated via photo- or Scanning Probe Microscopy Lithography, that is, flat polymeric surfaces with combinatorial combinations of physico-chemistries; and micro/nano-channels and nano-wells with critical dimen ....Probing the function of protein molecular motors on nano-fabricated structures. The function of protein linear molecular motors, which are natural dynamic bio-nano-devices with a ubiquitous importance in multicellular organisms, will be 'probed' with purposefully designed nano-structures fabricated via photo- or Scanning Probe Microscopy Lithography, that is, flat polymeric surfaces with combinatorial combinations of physico-chemistries; and micro/nano-channels and nano-wells with critical dimensions similar to the scale of the probed biomolecules. The project turns 'up-side down' the challenge of invasive nano-probing of biomolecules using it in an engineered manner. The fundamental understanding of linear molecular motors will impact on biomedical science and on the assessment of hybrid natural-artificial dynamic nano-devices.Read moreRead less
New Strategies for Monitoring DNA-Anticancer Drug Interactions. The highly successful cisplatin works by binding to DNA and partially unwinding or bending the DNA. As a consequence of the success if cisplatin, alternative anticancer drugs are being developed with reduced side effects for patients. One of the bottom necks in the development of alternative drugs is rapid screening of the efficacy on new leads. The proposed research will develop new technologies for monitoring DNA-drug binding, ....New Strategies for Monitoring DNA-Anticancer Drug Interactions. The highly successful cisplatin works by binding to DNA and partially unwinding or bending the DNA. As a consequence of the success if cisplatin, alternative anticancer drugs are being developed with reduced side effects for patients. One of the bottom necks in the development of alternative drugs is rapid screening of the efficacy on new leads. The proposed research will develop new technologies for monitoring DNA-drug binding, DNA damage and DNA repair using novel DNA biosensors. the novelty of the biosensor technology will be to use the modulation of charge transfer through DNA as a method for determining the structural changes that occur in DNA due to these events occurring.Read moreRead less
Nano-scale modification of gold surfaces for sensing mercury from gaseous effluents of alumina refineries. The Australian alumina industry contributes more than $5.4 billion export income annually. It is also a major driver of the rural economy with all but one of Australia's seven alumina refineries located in rural areas. In response to the industry's attempts to reduce the environmental impact of its processes, this project will conduct basic strategic research into the interaction between m ....Nano-scale modification of gold surfaces for sensing mercury from gaseous effluents of alumina refineries. The Australian alumina industry contributes more than $5.4 billion export income annually. It is also a major driver of the rural economy with all but one of Australia's seven alumina refineries located in rural areas. In response to the industry's attempts to reduce the environmental impact of its processes, this project will conduct basic strategic research into the interaction between mercury vapour and gold surfaces at the nano-level. Our principal aim is to develop mercury sensor technology suited to alumina refineries. This innovative technology will be a significant breakthrough in the control of mercury emissions and have many other applications.
Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989068
Funder
Australian Research Council
Funding Amount
$637,120.00
Summary
Equipment for Metastable Induced Electron Spectroscopy: surface analysis with excellent surface sensitivity. One of the major research strengths of Australia is surface science as it is important for both fundamental and industry related research. In many cases it is crucial to investigate the outermost layer of a material or mineral. Metastable Induced Electron Spectroscopy is an ideal technique as it is sensitive exclusively to the outermost layer of a broad range of samples. The information g ....Equipment for Metastable Induced Electron Spectroscopy: surface analysis with excellent surface sensitivity. One of the major research strengths of Australia is surface science as it is important for both fundamental and industry related research. In many cases it is crucial to investigate the outermost layer of a material or mineral. Metastable Induced Electron Spectroscopy is an ideal technique as it is sensitive exclusively to the outermost layer of a broad range of samples. The information gained is not accessible by any other method. The proposed equipment will be the first of this type in Australia and will complement existing surface science facilities. The project will enhance Australia's position in surface science internationally and a large number of projects will benefit from access to the equipment.Read moreRead less
Nanostructured Silicon-Based Tandem Solar Cells. The expected outcome from the project is a new generation of low-cost silicon solar cell that will significantly reduce the costs of generating electricity from sunlight. Solar cells are presently the world's most rapidly growing energy source, with Australians and Australian companies already major players in the associated rapidly expanding industry. Solar cells represent the most benign technology yet suggested for supplying the world's future ....Nanostructured Silicon-Based Tandem Solar Cells. The expected outcome from the project is a new generation of low-cost silicon solar cell that will significantly reduce the costs of generating electricity from sunlight. Solar cells are presently the world's most rapidly growing energy source, with Australians and Australian companies already major players in the associated rapidly expanding industry. Solar cells represent the most benign technology yet suggested for supplying the world's future energy needs. A cleaner environment in the future than would otherwise be likely is another expected outcome as is the creation of major new opportunities for Australian industry.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560683
Funder
Australian Research Council
Funding Amount
$321,953.00
Summary
A furnace stack for advanced photovoltaic, photonic and microfabrication applications. Advanced silicon photovoltaic, photonic, optoelectronic and micro-electromechanical devices require state of the art processing equipment for the deposition of thin dielectric films and for controlled doping of the devices. Key techniques include the deposition of stoichiometric and silicon rich silicon nitride and silicon dioxide films, and the controlled wafer doping with boron and phosphorus. A state of the ....A furnace stack for advanced photovoltaic, photonic and microfabrication applications. Advanced silicon photovoltaic, photonic, optoelectronic and micro-electromechanical devices require state of the art processing equipment for the deposition of thin dielectric films and for controlled doping of the devices. Key techniques include the deposition of stoichiometric and silicon rich silicon nitride and silicon dioxide films, and the controlled wafer doping with boron and phosphorus. A state of the art furnace stack is to be procured which will satisfy these requirements on industrially relevant wafer sizes up to 150mm. The equipment will support a broad range of research projects in the above fields, ranging from fundamental investigations to applied research carried out in collaboration with industry partners.Read moreRead less
High efficiency III-V solar cells based on low-dimensional quantum confined heterostructures. There is no doubt that clean and sustainable solar energy is one of the most viable energy sources to address the issues of climate change, global warming and depletion of conventional energy sources. With the great advantages offered by quantum confined nanostructures and nanotechnology, this project may lead to substantial efficiency improvement of current III-V solar cells (already higher efficiency ....High efficiency III-V solar cells based on low-dimensional quantum confined heterostructures. There is no doubt that clean and sustainable solar energy is one of the most viable energy sources to address the issues of climate change, global warming and depletion of conventional energy sources. With the great advantages offered by quantum confined nanostructures and nanotechnology, this project may lead to substantial efficiency improvement of current III-V solar cells (already higher efficiency than Si solar cells), making great contribution to the society and Nation in the areas of science, technology, environment, and economy.Read moreRead less
Materials Optimization and Interfacial Engineering of Cobalt and Europium Codoped ZnO for Multifunctional Spintronic Devices. Recent advances in new materials engineering holds a promise of surmounting the miniaturization limits of silicon technology by exploiting the spin of electrons in semiconductors. Spin transistor is among a number of nanoscale devices that may revolutionize telecommunications, computing and daily life. Current transistors are electronic circuits that make up most semico ....Materials Optimization and Interfacial Engineering of Cobalt and Europium Codoped ZnO for Multifunctional Spintronic Devices. Recent advances in new materials engineering holds a promise of surmounting the miniaturization limits of silicon technology by exploiting the spin of electrons in semiconductors. Spin transistor is among a number of nanoscale devices that may revolutionize telecommunications, computing and daily life. Current transistors are electronic circuits that make up most semiconductors; an international market will grow to US$1000bn per year in 2013. In a few years, the spin transistor will be on par with electronics. Success of this program will facilitate the development of spintronic materials and technologies, and also generated patents and intellectual properties, thus resulting in revenue for Australia through their commercialisations.Read moreRead less
Biomedical imaging with spins in nanoparticles: from single cell to whole-body scanning. The engineering of new biomedical technology is critical in underpinning our understanding of physiology and in the early detection of disease. This project will construct novel instrumentation for investigating normal and diseased physiology using bioagents based on diamond and ruby nanoparticles. The imaging and tracking techniques proposed are non-invasive, nontoxic, and provide high-resolution access to ....Biomedical imaging with spins in nanoparticles: from single cell to whole-body scanning. The engineering of new biomedical technology is critical in underpinning our understanding of physiology and in the early detection of disease. This project will construct novel instrumentation for investigating normal and diseased physiology using bioagents based on diamond and ruby nanoparticles. The imaging and tracking techniques proposed are non-invasive, nontoxic, and provide high-resolution access to specific physiological interactions of paramount importance in, for instance, understanding cancer pathways and developing strategies for targeted drug delivery.Read moreRead less