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Brain Plaques And Cognitive Decline In The Elderly - A Study Of Human Twins
Funder
National Health and Medical Research Council
Summary
One hallmark of Alzheimer’s disease (AD) is a build up of plaques in the brain, starting years before symptoms are observed. We will use PiB-PET brain scans to determine the degree of plaque build-up in pairs of twins at risk of developing AD, and calculate the heritability of these plaques. We will also be able to calculate (potentially modifiable) environmental factors that may be contributing to the relationship between plaques and memory and thinking.
Cognitive Decline In Type 2 Diabetes: Investigating The Contribution Of Neurodegeneration And Cerebrovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$608,520.00
Summary
Dementia occurs more commonly than expected in diabetes but the reasons are unknown. There could be a build up of deposits of the toxic protein in the brain that causes Alzheimer's disease. A new technique, using Positron Emmission Tomography (PET scans), will be used to answer this question in combination with MRI scans and serial cognitive testing in patients considered to be at-risk for dementia. The study will help direct research efforts aimed at dementia prevention and treatment.