The impact of female sex hormones on neurodevelopment. This project aims to characterise the contribution of sex hormones to the development of emotional brain circuits in female adolescents. Puberty is associated with profound changes in emotional behaviours in females, but we know little about the underlying brain mechanisms. In particular, research has neglected to consider the role of the sex hormones for which changes are a defining feature of female puberty (eg, oestradiol). This work will ....The impact of female sex hormones on neurodevelopment. This project aims to characterise the contribution of sex hormones to the development of emotional brain circuits in female adolescents. Puberty is associated with profound changes in emotional behaviours in females, but we know little about the underlying brain mechanisms. In particular, research has neglected to consider the role of the sex hormones for which changes are a defining feature of female puberty (eg, oestradiol). This work will be the first to comprehensively advance our understanding of the unique role of sex hormones in shaping the adolescent female brain. It will provide critical understanding of how individual differences in hormonal factors increase risk for emotional problems in females, and inform treatment strategies.Read moreRead less
Functional impact of high fat and high sugar diets on memory encoding. This project aims to determine the functional mechanisms of how fats and sugar affect neuronal processes vital for learning and memory. Expected outcomes will define the neural mechanisms underpinning cognitive changes in emotional and spatial memory encoding, and how these relate to brain and metabolic parameters. This will provide benefits by unveiling the possible consequences of dietary fat and sugar on the brain, and th ....Functional impact of high fat and high sugar diets on memory encoding. This project aims to determine the functional mechanisms of how fats and sugar affect neuronal processes vital for learning and memory. Expected outcomes will define the neural mechanisms underpinning cognitive changes in emotional and spatial memory encoding, and how these relate to brain and metabolic parameters. This will provide benefits by unveiling the possible consequences of dietary fat and sugar on the brain, and the mechanisms of neuroplasticity enhancing interventions.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101107
Funder
Australian Research Council
Funding Amount
$412,744.00
Summary
Ahead of the Game: Balancing the Gaming Industry and Public Interest. This project battles the risks and embraces the benefits of digital gaming. There is a risk that one loses control of their gaming and prioritises it over other duties. This is offset by the benefits of using digital games for health. It is the first to decode and use the health data embedded in the connection between the gamer and their game persona (avatar). It does this by concurrently assessing important gamer, family, cul ....Ahead of the Game: Balancing the Gaming Industry and Public Interest. This project battles the risks and embraces the benefits of digital gaming. There is a risk that one loses control of their gaming and prioritises it over other duties. This is offset by the benefits of using digital games for health. It is the first to decode and use the health data embedded in the connection between the gamer and their game persona (avatar). It does this by concurrently assessing important gamer, family, cultural and game structure features. Findings will prompt the ethical growth of the Australian Health games industry and inform strategies to combat gaming disorder by tailoring games to users' needs. This will uniquely benefit Australians by re-directing this growing industry to better serve the public interest.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150101108
Funder
Australian Research Council
Funding Amount
$352,000.00
Summary
The ups and downs of visuospatial attention. The brain has a remarkable capacity to provide a coherent experience of the world by seamlessly integrating sights and sounds from different locations. It is only after brain damage, or when faced with a high attentional load, that our limitations become apparent. The project aims to investigate these limitations by determining how spatial location influences attention in relation to distractibility, cross-modal input and emotionality. Eye tracking an ....The ups and downs of visuospatial attention. The brain has a remarkable capacity to provide a coherent experience of the world by seamlessly integrating sights and sounds from different locations. It is only after brain damage, or when faced with a high attentional load, that our limitations become apparent. The project aims to investigate these limitations by determining how spatial location influences attention in relation to distractibility, cross-modal input and emotionality. Eye tracking and physiological measures of arousal will be combined with traditional cognitive measures to provide a deeper understanding of spatial attention. This project aims to improve attentional models and develop innovative strategies to increase safety by decreasing inattention and distraction.Read moreRead less
Circadian photoreceptor sensitivity and impacts of modern lighting on sleep. Light has powerful non-visual effects, including effects on sleep. These non-visual effects are mediated by cells in the eye that are most sensitive to blue light. There are large individual differences in sensitivity to non-visual effects of light that are not understood and that would give great insight into suboptimal sleep, which has become widespread in modern society. This study will be the first systematic examin ....Circadian photoreceptor sensitivity and impacts of modern lighting on sleep. Light has powerful non-visual effects, including effects on sleep. These non-visual effects are mediated by cells in the eye that are most sensitive to blue light. There are large individual differences in sensitivity to non-visual effects of light that are not understood and that would give great insight into suboptimal sleep, which has become widespread in modern society. This study will be the first systematic examination of individual differences in the effect of blue light on sleep and will uncover how alterations in the gene responsible for the effects of blue light on sleep (OPN4) contribute to these differences. This will lead to scalable individualised solutions to the unmet problem of how modern light environments impact sleep.Read moreRead less
Hunger flexibly modifies hypothalamic neural circuits responding to threat. Animal and human behaviour frequently involves a choice between actions or goals with conflicting positive and negative outcomes. However, the appropriate action or goal in conflicting situations often depends on physiological pressures like hunger, stress and mating opportunities. For example, the need for resources within an environment, such as food, drives approach behaviour, whereas threats to survival, such as pred ....Hunger flexibly modifies hypothalamic neural circuits responding to threat. Animal and human behaviour frequently involves a choice between actions or goals with conflicting positive and negative outcomes. However, the appropriate action or goal in conflicting situations often depends on physiological pressures like hunger, stress and mating opportunities. For example, the need for resources within an environment, such as food, drives approach behaviour, whereas threats to survival, such as predator cues, enhance avoidance behaviour. This project will uncover the neural circuitry and endocrine mechanisms through which hunger influences hypothalamic threat-detecting circuits that suppress food intake. These studies provide a new hypothalamic model to understand risk/reward decision in the brain.Read moreRead less
Evaluating the Quality of Scientific Research in Psychology. Buttressing public trust in science has never been more important, yet many sciences are experiencing a crisis of confidence. The current system of relying on journal prestige to calibrate our confidence in individual research findings has created corrupt incentives for scientists, and risks undermining public trust in science. Thousands of scientists and institutions around the world have indicated that research evaluation needs an ov ....Evaluating the Quality of Scientific Research in Psychology. Buttressing public trust in science has never been more important, yet many sciences are experiencing a crisis of confidence. The current system of relying on journal prestige to calibrate our confidence in individual research findings has created corrupt incentives for scientists, and risks undermining public trust in science. Thousands of scientists and institutions around the world have indicated that research evaluation needs an overhaul by signing the Declaration on Research Assessment. One solution is to create a public, transparent, and valid process for producing and sharing expert evaluations of individual papers. This project aims to launch this reform in psychology, and partner with PREreview to help it spread to other fields.Read moreRead less