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Research Topic : bacterial virulence factors
Field of Research : Epidemiology
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  • Funded Activity

    Behavioural And Microbial Risk Factors Associated With Bacterial Vaginosis In Young Women

    Funder
    National Health and Medical Research Council
    Funding Amount
    $290,032.00
    Summary
    Bacterial vaginosis (BV) is one of the commonest genital infections in women of reproductive age. Few data have determined the incidence of BV among young low risk women and the associated risk factors. This study aims to establish the incidence of BV in a cohort of young women and determine if BV is sexually transmitted. We hope this research will led to improvements in management and treatment of BV.
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    Funded Activity

    Genetic And Environmental Risk Factors For Colorectal Cancer: Anatomic Site Specificity

    Funder
    National Health and Medical Research Council
    Funding Amount
    $560,000.00
    Summary
    Cancer of the large bowel (colorectal cancer) is the second most common cancer in Australians and is becoming more common. Despite this, there is still much uncertainty about what causes some people to develop this cancer. We believe that some of this uncertainty arises because there are actually different causes of cancer for different sections of the colon and rectum. This study aims to collect information from 1000 people with colorectal cancer and 1000 people without colorectal cancer, and c .... Cancer of the large bowel (colorectal cancer) is the second most common cancer in Australians and is becoming more common. Despite this, there is still much uncertainty about what causes some people to develop this cancer. We believe that some of this uncertainty arises because there are actually different causes of cancer for different sections of the colon and rectum. This study aims to collect information from 1000 people with colorectal cancer and 1000 people without colorectal cancer, and compare various factors such as their genetic makeup, diet, AND lifestyle. We expect to find that some factors are more common in people with cancer in the upper parts of the bowel, while other factors are more common in people with cancer in the lower parts of the bowel. This kind of information can be used to design programs to prevent colorectal cancer. For example, we might advise people to exercise more or eat more fish in order to decrease their chances of developing this cancer.
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    Optimising Large-scale Public Health Interventions To Control Neglected Tropical Diseases

    Funder
    National Health and Medical Research Council
    Funding Amount
    $318,768.00
    Summary
    Neglected tropical diseases (NTD) are a group of health conditions that affect the poorest of the poor, particularly in remote and rural areas. They affect the most vulnerable communities and cause substantial, chronic health harms impairing personal and social development. Several debilitating NTD are common in remote indigenous communities and Pacific islands. I propose a series of studies to investigate new strategies to control NTD in large populations where these diseases are endemic.
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    Funded Activity

    Novel Genetic And Environmental Modifiers Of The Risk Of Iron Overload-related Disease In HFE-associated Hereditary Haemochromatosis In Cohort Of Middle-aged Australians

    Funder
    National Health and Medical Research Council
    Funding Amount
    $451,716.00
    Summary
    People who carry mutations in the HFE gene are pre-disposed to body iron overload but not all of them developed subsequent disease. According to the investigators of the “HealthIron” study in Melbourne, only 28% of men and 1% of women with faulty HFE genes go on to develop disease. This study has recruited more than 1,000 people from the community, and will determine which environmental and genetic risk factors stop people with iron overload from getting symptoms of disease.
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    Funded Activity

    Novel Molecular Markers Of Lung Cancer Risk And Survival

    Funder
    National Health and Medical Research Council
    Funding Amount
    $824,765.00
    Summary
    Lung cancer remains the most lethal cancer worldwide, yet little is known of the risk factors beyond that of tobacco smoking and certain occupational exposures. We have assembled a large international consortium comprising 24 cohort studies and over 10,000 to validate associations between B-vitamins and lung cancer risk particularly in never and former smokers. We propose to expand this study and use the Melbourne Collaborative Cohort Study and the rest of the consortium to identify novel biomar .... Lung cancer remains the most lethal cancer worldwide, yet little is known of the risk factors beyond that of tobacco smoking and certain occupational exposures. We have assembled a large international consortium comprising 24 cohort studies and over 10,000 to validate associations between B-vitamins and lung cancer risk particularly in never and former smokers. We propose to expand this study and use the Melbourne Collaborative Cohort Study and the rest of the consortium to identify novel biomarkers of risk and survival.
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    Funded Activity

    Genetic Epidemiology Of Endometrial Cancer: Towards Understanding Aetiology And Improving Risk Prediction.

    Funder
    National Health and Medical Research Council
    Funding Amount
    $353,573.00
    Summary
    Studies investigating thousands of genetic markers have revolutionised our understanding of genes involved in cancer, and shown that a single gene can be associated with multiple cancers. We will conduct the largest ever study to find new genes for endometrial cancer, the most common gynaecological cancer. Our unique approach will examine >11million markers across the genome, some specifically in regions known to be important for other cancers. Findings will be used for risk prediction models .... Studies investigating thousands of genetic markers have revolutionised our understanding of genes involved in cancer, and shown that a single gene can be associated with multiple cancers. We will conduct the largest ever study to find new genes for endometrial cancer, the most common gynaecological cancer. Our unique approach will examine >11million markers across the genome, some specifically in regions known to be important for other cancers. Findings will be used for risk prediction models.
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    Funded Activity

    Clinical, Environmental And Genetic Factors And The Risk Of Oesophageal Cancer

    Funder
    National Health and Medical Research Council
    Funding Amount
    $145,685.00
    Summary
    Oesophageal cancer is a rapidly fatal disease which is becoming more common in Australia, the United States and other industrialised nations. This study will examine the mechanisms leading to the development of oesophageal cancer and aims to measure the effects of genes and environment on the burden of cancer. Ultimately, this research will help target persons at highest risk so that screening, prevention and surveillance efforts can be directed more effectively.
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    Funded Activity

    POPULATION-LEVEL RELEVANCE OF RISK FACTORS FOR CANCER

    Funder
    National Health and Medical Research Council
    Funding Amount
    $319,692.00
    Summary
    This research will provide novel up-to-date evidence-based information on the population-level relevance of lifestyle-related risk factors for cancer in Australia, by applying an advanced disease burden measure to established Australian cohort studies. This knowledge on the national cancer burden is essential for targeting cancer interventions for those at highest risk and evaluating their effectiveness.
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    Funded Activity

    Genetic Epidemiology Of Allergies And Chronic Respiratory Diseases

    Funder
    National Health and Medical Research Council
    Funding Amount
    $422,850.00
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    Funded Activity

    Investigation Of Candidate Aetiologic Organisms Of Bacterial Vaginosis In Diverse And Unique Epidemiological And Clinical Studies

    Funder
    National Health and Medical Research Council
    Funding Amount
    $564,438.00
    Summary
    Bacterial vaginosis (BV), a vaginal infection affecting 10% of Australian women, is an important cause of premature birth, yet its cause is unknown. We are conducting studies to understand the cause of BV in order to improve diagnosis and treatment.
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    Showing 1-10 of 91 Funded Activites

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