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Molecular Analysis Of Endocarditis Causing Strains Of Staphylococcus Aureus
Funder
National Health and Medical Research Council
Funding Amount
$110,960.00
Summary
"Staphylococcus aureus" or "Golden Staph” is one of the principal causes of infective endocarditis, the infection of the endocardial surfaces of the heart and heart valves that may result in valvular insufficiency and eventual heart failure. This work will define the molecular mechanisms that allow S. aureus to survive and persist on endocardial surfaces. Such insight may lead to new future treatment regimes for infective endocarditis.
Optimising Management Of Injection-related Infections In People Who Inject Drugs
Funder
National Health and Medical Research Council
Funding Amount
$132,743.00
Summary
People who inject drugs are a vulnerable group who are at increased risk of bacterial infections, which can lead to serious illness and death. This project aims to optimize management of bacterial infections in people who inject drugs. Measuring the current burden of infections, analysing different management strategies employed in hospitals and discussing attitudes and barriers to care with both healthcare workers and people who inject drugs will provide the evidence to optimize ongoing care.
Establishing The Use Of Bacterial Genomics In Australia
Funder
National Health and Medical Research Council
Funding Amount
$157,669.00
Summary
We propose to establish a set of fully assembled reference genomes through new technologies and methods to analyse data from high throughput genome sequencing of important bacterial pathogens in Australia. We aim to demonstrate the capabilities of genome sequencing in clinical situations by comparing the genomes from clinical bacterial isolates to the established and annotated reference genomes.
Factors That Influence Disease Severity In Tuberculosis
Funder
National Health and Medical Research Council
Funding Amount
$149,076.00
Summary
Tuberculosis (TB) is a major global health problem and is one of the leading causes of death from an infectious disease worldwide. The severity of disease that occurs with TB is dependent on many complex factors including the infected person’s immune system and factors related to the TB organism itself. This research will determine the key factors that cause severe disease in TB which will translate into improved care of TB patients and enhance further research in this field.