Genomic Analysis Of Host Response To Influenza A Infection
Funder
National Health and Medical Research Council
Funding Amount
$168,530.00
Summary
Influenza virus infects millions of people globally. However, it remains poorly understood why some infected individuals succumb to life threatening complications whilst others recovered relatively unaffected. This study use advance molecular technique to study influenza infection. It aims to identify the key steps in our immune systems that are progressively disrupted during influenza infection and how this process lead to a break down in our natural defence against the virus.
Defining The Mechanism Of Invasive Disease Caused By Diverse Group A Streptococcal M Serotypes
Funder
National Health and Medical Research Council
Funding Amount
$393,061.00
Summary
Streptococcus pyogenes (group A Streptococcus; GAS) causes life-threatening invasive infections including flesh-eating disease and toxic shock syndrome (>600,000 cases and 163,000 deaths per year). We recently discovered the trigger for invasive disease in a globally disseminated GAS strain. The aim of this work is to determine whether this trigger applies to other strains associated with GAS invasive disease. These studies will allow the development of new therapeutics and treatments.
Understanding, Reducing And Preventing Communicable Diseases Using Applied Pathogen Genomics
Funder
National Health and Medical Research Council
Funding Amount
$303,014.00
Summary
Infectious diseases are a major threat to human health. New molecular methods, particularly whole genome sequencing, promise a revolution in the way in which infections are diagnosed, detected and tracked in the 21st century. This research will use cutting edge molecular technologies to understand the factors that lead to the emergence, evolution and spread of important bacteria, including bacteria that are resistant to antibiotics.
Improving Outcomes In Patients With Community-acquired Severe Sepsis: The Role Of Pre-hospital Antibiotics.
Funder
National Health and Medical Research Council
Funding Amount
$265,138.00
Summary
Severe sepsis occurs when infection causes organ dysfunction. If not treated early, outcomes remain poor. Foremost in effectively treating this condition is the initiation of broad-spectrum antibiotics. This Fellowship will assess the feasibility, efficacy, and safety of pre-hospital antibiotics administered by paramedics to patients with suspected community-acquired severe-sepsis, as a means to improve patient outcomes in this highly vulnerable group.
Using Genetic Tools To Study Helicobacter Pylori Pathogenesis And Persistence
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
H. pylori infection is the leading cause of gastric ulcer disease and stomach cancer. In light of emerging antibiotic resistance and failed vaccine trials, alternative therapies are needed to treat this lifelong infection. This project aims to develop tools to identify and characterize genes required by H. pylori for infection which will serve as new drug targets. This new knowledge will also contribute to a better understanding of the persistence of this and other bacteria.
Therapeutic Thermal Regulation In Critical Illness
Funder
National Health and Medical Research Council
Funding Amount
$189,384.00
Summary
Patients who are admitted to intensive care units often develop abnormalities of their body temperature as part of their illness. Common illnesses include infections and injuries to the brain from trauma or strokes. Clinicians are unsure of how to react to these changes in temperature. My research is designed to provide high quality evidence on body temperature and the use of treatments, so that clinicians can improve patient outcomes.