Discovery Early Career Researcher Award - Grant ID: DE170100354
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
How adaptation increases the intensity of sexual conflict. This project aims to test a theory that a species’ adaptation to its environment may cause sexual conflicts where gene variants increase the fitness of one sex but decrease it in the other. When populations harbour large numbers of these sexually antagonistic genes, adaptation is hampered and extinction becomes more likely. This project will fuse experimental evolution with quantitative genetic approaches to test this theory. Understandi ....How adaptation increases the intensity of sexual conflict. This project aims to test a theory that a species’ adaptation to its environment may cause sexual conflicts where gene variants increase the fitness of one sex but decrease it in the other. When populations harbour large numbers of these sexually antagonistic genes, adaptation is hampered and extinction becomes more likely. This project will fuse experimental evolution with quantitative genetic approaches to test this theory. Understanding sex differences in adaptation and the evolution of sexual dimorphism could enable scientists to predict levels of sexually deleterious variation under changing environmental conditions. Its findings are expected to provide new insights into sex differences in adaptation.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170101193
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Testing models for sex evolution and maintenance. This project aims to study the evolution of sex. The short-term costs of sexual reproduction seem to outweigh its benefits, making its widespread success an evolutionary conundrum. The project will test high-profile models which predict higher rates of sex in individuals poorly adapted to their environment than in well adapted individuals. This process allows sex genes to escape from unfavourable genetic backgrounds and hastens local adaptation o ....Testing models for sex evolution and maintenance. This project aims to study the evolution of sex. The short-term costs of sexual reproduction seem to outweigh its benefits, making its widespread success an evolutionary conundrum. The project will test high-profile models which predict higher rates of sex in individuals poorly adapted to their environment than in well adapted individuals. This process allows sex genes to escape from unfavourable genetic backgrounds and hastens local adaptation of populations to their environment. This work is expected to discover the link between reproductive mode and adaptation, strengthen research into consequences of environmental change, and solve a long-standing puzzle of evolutionary biology.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150101484
Funder
Australian Research Council
Funding Amount
$365,000.00
Summary
Developing custom RNA processing tools. The pentatricopeptide repeat (PPR) code has been described as an RNA code that connects specific residues in PPR motifs with the precise recognition of individual nucleotides. It will enable the design of custom RNA-binding proteins with tremendous potential in research and biotechnology. RNA-processing technologies aim to be developed that consist of PPR domains fused with an additional endonuclease domain for cleaving chosen target RNAs. In the longer te ....Developing custom RNA processing tools. The pentatricopeptide repeat (PPR) code has been described as an RNA code that connects specific residues in PPR motifs with the precise recognition of individual nucleotides. It will enable the design of custom RNA-binding proteins with tremendous potential in research and biotechnology. RNA-processing technologies aim to be developed that consist of PPR domains fused with an additional endonuclease domain for cleaving chosen target RNAs. In the longer term, successful technologies will be tested in living organisms for biotechnology applications or in new therapeutic strategies.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230101173
Funder
Australian Research Council
Funding Amount
$374,318.00
Summary
Inhibiting adenylate-forming enzymes via a new reaction-hijacking mechanism. This project aims to identify and validate the adenylate-forming enzymes that are susceptible to reaction-hijacking inhibition in malaria parasites. This class of enzymes can be induced to synthesise their own nucleoside sulfamate inhibitor conjugates via a novel mechanism. This project expects to provide new knowledge about the molecular basis of this novel inhibition mechanism and susceptible target enzymes in the par ....Inhibiting adenylate-forming enzymes via a new reaction-hijacking mechanism. This project aims to identify and validate the adenylate-forming enzymes that are susceptible to reaction-hijacking inhibition in malaria parasites. This class of enzymes can be induced to synthesise their own nucleoside sulfamate inhibitor conjugates via a novel mechanism. This project expects to provide new knowledge about the molecular basis of this novel inhibition mechanism and susceptible target enzymes in the parasites. Adenylate-forming enzymes play critical roles in a diverse range of biochemical pathways, such as protein translation and fatty acid metabolism. The project seeks to deliver a new paradigm for the design of future antiparasitic agents.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100466
Funder
Australian Research Council
Funding Amount
$462,647.00
Summary
Mito-nuclear coevolution as an engine of biodiversity. This project aims to advance understanding of the processes that drive speciation and generate biodiversity. It will use Australia’s native social bees to test whether genetic diversity in mitochondrial genomes drives biodiversity at the population level, combining molecular and field studies in this uniquely tractable natural system. The expected outcome is a significant advance in knowledge of how coevolution between the two genomes of euk ....Mito-nuclear coevolution as an engine of biodiversity. This project aims to advance understanding of the processes that drive speciation and generate biodiversity. It will use Australia’s native social bees to test whether genetic diversity in mitochondrial genomes drives biodiversity at the population level, combining molecular and field studies in this uniquely tractable natural system. The expected outcome is a significant advance in knowledge of how coevolution between the two genomes of eukaryotic cells - mitochondrial and nuclear - affect the observable diversity of the natural world. The project is also expected to benefit the management and conservation of Australian native bees, which are vital pollinators in our natural and agro-ecosystems. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102821
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Molecular genetic adaptive processes in natural co-evolution between rabbits and the rabbit haemorrhagic disease virus. This project will use extensive sampling and long-term field data to reveal ongoing co-evolutionary mechanisms behind the increasing resistance of pest Australian wild rabbits against a viral pathogen. The results will increase the understanding of evolutionary mechanisms in nature and will provide basic information for biological pest control of rabbits.
Discovery Early Career Researcher Award - Grant ID: DE200101019
Funder
Australian Research Council
Funding Amount
$414,331.00
Summary
Mechanisms determining ecological resilience to climate change. This project aims to improve our understanding of the evolutionary mechanisms by which organisms adapt to climate change, and how this may lead to ecological resilience. It will test how rapid adaptation can occur in response to stressful environments predicted under climate change scenarios. By understanding the genetic mechanisms by which organisms adapt to environmental stresses, we can better forecast the effects of climate cha ....Mechanisms determining ecological resilience to climate change. This project aims to improve our understanding of the evolutionary mechanisms by which organisms adapt to climate change, and how this may lead to ecological resilience. It will test how rapid adaptation can occur in response to stressful environments predicted under climate change scenarios. By understanding the genetic mechanisms by which organisms adapt to environmental stresses, we can better forecast the effects of climate change on natural systems. Expected outcomes include an improved ability to make informed conservation and management decisions, with resulting benefits including the protection of human health, agricultural industries, and our iconic flora and fauna. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160101574
Funder
Australian Research Council
Funding Amount
$374,360.00
Summary
Understanding the Long-Term Decline in Internal Migration. The project seeks to provide insights into the changing nature of internal migration. Internal migration rates have declined continuously since the 1970s in most advanced economies. This decline in human mobility may affect the functioning of the economy and individuals’ aspirations, but remains poorly recognised and understood. This project aims to establish the onset and pace of the migration decline for a sample of countries. It also ....Understanding the Long-Term Decline in Internal Migration. The project seeks to provide insights into the changing nature of internal migration. Internal migration rates have declined continuously since the 1970s in most advanced economies. This decline in human mobility may affect the functioning of the economy and individuals’ aspirations, but remains poorly recognised and understood. This project aims to establish the onset and pace of the migration decline for a sample of countries. It also aims to identify the causes of this change by identifying linkages between the drop in migration rates and the broader socio-demographic transitions of the past 30 years in Australia, Canada and the United Kingdom. Understanding this issue may support the development of appropriate economic and social policy responses.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150101904
Funder
Australian Research Council
Funding Amount
$385,481.00
Summary
Interactions of sexual selection & ecological divergence during speciation. Understanding the processes driving speciation is fundamental to understanding how biodiversity is generated. The two main forces underlying speciation, ecological divergence and sexual selection, are well characterised, yet how they interact during the speciation process is remarkably poorly understood. This project aims to test hypotheses regarding how ecological divergence and sexual selection interact during speciati ....Interactions of sexual selection & ecological divergence during speciation. Understanding the processes driving speciation is fundamental to understanding how biodiversity is generated. The two main forces underlying speciation, ecological divergence and sexual selection, are well characterised, yet how they interact during the speciation process is remarkably poorly understood. This project aims to test hypotheses regarding how ecological divergence and sexual selection interact during speciation, from its inception to its completion. In doing so, this research aims to identify genomic regions underlying divergence in colour patterns, which are important for ecological and sexual interactions. Consequently, this project will significantly enhance our understanding of ecological and genetic mechanisms underlying speciation.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120100214
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Re-evaluating evolution by examining developmental plasticity in response to the social environment. Our understanding of trait evolution is derived from our assumption that traits are a signal of male quality as they are costly to produce. The project will integrate this concept with a new theory stating that males shift their development to exploit the weaknesses of rivals; thereby leading to a more holistic understanding of evolution.