Understanding The Role Of The Two Major Bacterial Pathogens In The Upper And Lower Airways Of Indigenous Children With Chronic Lung Disease
Funder
National Health and Medical Research Council
Funding Amount
$743,282.00
Summary
Lung infections are a major disease burden worldwide. Indigenous Australians are affected more; adults with severe lung disease can die in their 30s and 40s. These diseases start early, yet no in-depth studies of bacteria causing lung infections in children have been done. Our expert team proposes to use existing lung fluids from nearly 500 children with chronic lung disease (58% Indigenous), and state-of-the-art laboratory methods, to inform the design of vaccines to prevent lung disease.
Diseases caused by the pneumococcus represent the largest cause of vaccine preventable death in the world today, mainly pneumonia and meningitis. In 2011, 16 developing countries will introduce pneumococcal conjugate vaccines, none in east Asia. Lack of research has been a major barrier to their use in the region. We have established an international centre of excellence in the field and we seek support to extend the capacity of this group and to transfer the technology to Vietnam.
Establishing the provenance of Torres Strait Islander remains: genetics, craniometrics and isotopes. The repatriation of Aboriginal and Torres Strait Islander remains has been a focus of Commonwealth and State Governments for over two decades. It remains as a significant social and cultural issue for many Indigenous Australians. One of the main hurdles to repatriation is the fact that hundreds, and possibly thousands of human remains have very little contextual detail associated with them. A num ....Establishing the provenance of Torres Strait Islander remains: genetics, craniometrics and isotopes. The repatriation of Aboriginal and Torres Strait Islander remains has been a focus of Commonwealth and State Governments for over two decades. It remains as a significant social and cultural issue for many Indigenous Australians. One of the main hurdles to repatriation is the fact that hundreds, and possibly thousands of human remains have very little contextual detail associated with them. A number of techniques have been developed in the field of biological anthropology to reconstruct the history of individual skeletal remains. This innovative project aims to use advances in the fields of ancient DNA, isotope analysis and craniometrics to resolve the provenance of 113 trophy skulls from the Torres Strait Islands.Read moreRead less