Investigating B Cell Development, Maintenance And High-affinity Antibody Production By ENU Mutagenesis
Funder
National Health and Medical Research Council
Funding Amount
$408,388.00
Summary
B cells are essential for the protection against infections. This application aims to identify new genes that are crucial for the development or function of B cells and will investigate how mutations in newly discovered genes contribute to defects in the development and function of B cells and the pathogenesis of B cell leukaemia.
Modeling Human Actin Related Protein 2/3 Complex Subunit 1B (ARPC1B) Deficiency In Mice
Funder
National Health and Medical Research Council
Funding Amount
$755,005.00
Summary
The actin cytoskeleton forms the structure that not only keeps cells in their normal shape but is also essential for the movement of cells and for interaction between cells. We have recently identified the first patients with an immunodeficiency caused by a defect in a gene called ARPC1B, which plays a crucial role in the regulation of actin. Through the investigation of novel mouse models we will elucidate the pathomechanism underlying the disease of these patients.
Role Of SPPL2A On B Cell Survival And Antibody Production In Mice And Humans
Funder
National Health and Medical Research Council
Funding Amount
$592,989.00
Summary
B lymphocytes are a specialised type of blood cells that produce antibodies in response to a pathogen or a vaccine. We have recently discovered that all mature B cells depend for their survival on a previously unknown protein called SPPL2A. This application will investigate the molecular mechanism through which SPPL2A contributes to the survival of B cells. We will also investigate if humans with currently unexplained B cell deficiency have mutations in SPPL2A.
Genotypes And Phenotypes Of Human Primary Non-congenital Antibody Deficiency
Funder
National Health and Medical Research Council
Funding Amount
$544,692.00
Summary
Antibodies represent a key component of the immune system, and a particularly important in defence against bacterial and viral infections. In some individuals, antibody production fails, rendering them more susceptible to infection. In most cases, the mechanism of antibody failure is unknown. This project seeks to determine the genetic and cellular mechanisms of antibody failure. This could improve diagnosis for immune deficiency, and improve our overall understanding of the immune system.
Understanding The Role Of The Putative Phospholipid Translocase ATP11c In B Cell Development
Funder
National Health and Medical Research Council
Funding Amount
$455,153.00
Summary
The immune system protects humans against recurrent infections with a wide range of pathogens. Formation of antibodies is a crucial element of the immune response. Defects in the production of antibodies can lead to recurrent and often life-threatening infections. This project seeks to understand a genetic defect in mice resulting in an almost complete absence of antibody producing cells, thereby causing a disease that is similar to some forms of human immunodeficiency.
How BANK1 Pathway Defects In B Cells Cause Human Lupus
Funder
National Health and Medical Research Council
Funding Amount
$1,316,839.00
Summary
Autoimmune diseases affect 1 in 20 Australians and are incurable. To find effective therapies, we need to understand the genes that cause disease in humans. We have sequenced the entire genome of patients with an autoimmune disease and found several patients carrry two mutations in genes important for activation of B cells and shown these mutations cause disease. We plan to understand how these genes prevent autoimmunity, and to identify the best treatment for patients with these mutations.
Uncovering The Basis Of Inflammatory And Immunodeficiency Diseases
Funder
National Health and Medical Research Council
Funding Amount
$15,718,075.00
Summary
A world-class team from 3 institutions, spanning disciplines of clinical and experimental immunology, therapeutics, signalling and genetics, will identify how immune and inflammatory responses are controlled in both health and disease. The major outcomes of this work will be the generation of new knowledge, concepts and approaches to diagnose, prevent and treat the major human health problems of autoimmune diseases, inflammation, allergy and immunodeficiency.
Yarning with our mob about human papillomavirus (HPV) vaccination uptake. This project aims to identify a range of modifiable factors that affect the participation of Indigenous adolescents in human papillomavirus (HPV) vaccination school programs. The project expects to generate new knowledge by combining Indigenous methodologies and a socioecological model to explore policy, community, interpersonal and intrapersonal factors impacting HPV vaccination uptake for this population. Expected outcom ....Yarning with our mob about human papillomavirus (HPV) vaccination uptake. This project aims to identify a range of modifiable factors that affect the participation of Indigenous adolescents in human papillomavirus (HPV) vaccination school programs. The project expects to generate new knowledge by combining Indigenous methodologies and a socioecological model to explore policy, community, interpersonal and intrapersonal factors impacting HPV vaccination uptake for this population. Expected outcomes include a more comprehensive understanding of the factors behind the low rates of HPV vaccination among Indigenous adolescents. This information should provide significant benefits including the identification of modifiable factors to increase HPV vaccination rates for Indigenous adolescents.Read moreRead less
Co-designing a Food Sovereignty Model with Indigenous Communities. Food sovereignty asserts the rights of people and communities to healthy and culturally appropriate foods through determination of their own food and agriculture systems. With food insecurity higher among Indigenous households; a food sovereignty approach offers the potential for sustainable long-term solutions that maintain human dignity and reinvigorate knowledge systems. Drawing on national and international perspectives and u ....Co-designing a Food Sovereignty Model with Indigenous Communities. Food sovereignty asserts the rights of people and communities to healthy and culturally appropriate foods through determination of their own food and agriculture systems. With food insecurity higher among Indigenous households; a food sovereignty approach offers the potential for sustainable long-term solutions that maintain human dignity and reinvigorate knowledge systems. Drawing on national and international perspectives and using Indigenous research methodologies, this project aims to co-design a food sovereignty model that will enable Indigenous communities to effectively address food insecurity according to their local contexts. Both the process and solutions will contribute to improvements in physical, mental and social wellbeing.Read moreRead less
Historical frontier violence: drivers, legacy and the role of truth-telling. This project aims to build data to identify the historical factors that incited frontier violence; quantify the legacy on communities today and conduct fieldwork to understand how historical trauma is transmitted across generations. This project expects to develop new knowledge on the circumstances and legacy of settlement and the origins of gaps in life prospects between Indigenous and non-Indigenous Australians. Our e ....Historical frontier violence: drivers, legacy and the role of truth-telling. This project aims to build data to identify the historical factors that incited frontier violence; quantify the legacy on communities today and conduct fieldwork to understand how historical trauma is transmitted across generations. This project expects to develop new knowledge on the circumstances and legacy of settlement and the origins of gaps in life prospects between Indigenous and non-Indigenous Australians. Our expectation is that this will increase public acceptance of the circumstances of settlement and the need to make amends. This project should help increase public support for truth-telling and better relations between Indigenous and non-Indigenous Australians, a vital step towards reconciliation and healing the nation. Read moreRead less