How the brain regulates blood pressure. This project will test whether a group of nerve cells in the rostral ventrolateral medulla generate sympathetic activity in blood vessels. The brain regulates blood pressure through several pathways, including nerves in the sympathetic nervous system that constrict blood vessels and increase the heart rate. Activity of these sympathetic nerves regulates blood pressure, but it is unknown which nerve cells in the brain cause this activity. This information i ....How the brain regulates blood pressure. This project will test whether a group of nerve cells in the rostral ventrolateral medulla generate sympathetic activity in blood vessels. The brain regulates blood pressure through several pathways, including nerves in the sympathetic nervous system that constrict blood vessels and increase the heart rate. Activity of these sympathetic nerves regulates blood pressure, but it is unknown which nerve cells in the brain cause this activity. This information is essential to understand how blood pressure is controlled under healthy conditions.Read moreRead less
Novel computational tools for the analysis of sympathetic nervous system activity. This project will investigate electrical signals from the heart, resulting in novel tools for the assessment of sympathetic nervous system activity. The findings will contribute to advancing Australia's international leading position in health technology and improve community health.
Discovery Early Career Researcher Award - Grant ID: DE130100537
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Neural regulation of immunity following brain injury. Following a brain injury, the brain tries to protect itself by blocking all inflammation. However, this renders the host with impaired immunity and increased risks to infections. The project aims to delineate the mechanisms behind this response, with the expected outcome of highlighting the important interplay between the nervous and immune system.
Blood pressure control by neural activation: underlying mechanisms of electric field stimulation and photostimulation of genetically targeted neurones. This project aims to understand how nerve stimulation can be used to treat drug-resistant high blood pressure. The project will lead to new benchmarks for interfacing novel technology with the nervous system and to development and enhancement of commercial devices similar to a cardiac pacemaker for patients with limited treatment options and poor ....Blood pressure control by neural activation: underlying mechanisms of electric field stimulation and photostimulation of genetically targeted neurones. This project aims to understand how nerve stimulation can be used to treat drug-resistant high blood pressure. The project will lead to new benchmarks for interfacing novel technology with the nervous system and to development and enhancement of commercial devices similar to a cardiac pacemaker for patients with limited treatment options and poor prognosis.Read moreRead less