Mapping the connectome that controls blood pressure. The connections that an individual brain cell receives from other cells ultimately determines its behaviour. Using a revolutionary new technique, the project will create a map of the brain cells that control blood pressure.
Rhombomeric Topography of Structures in the Adult Mouse: Evidence from Avian Homologies and Transgenic Mice. The brainstem of birds has been shown to be formed by a line of segments, like carriages of a train. The same arrangement exists in the embryos of mammals, but is hidden in the adult mammalian brain. We will transfer our detailed knowledge of bird brains to make a maps of the brainstem segments in adult mice. We will then test this map with special gene markers which will reveal the occul ....Rhombomeric Topography of Structures in the Adult Mouse: Evidence from Avian Homologies and Transgenic Mice. The brainstem of birds has been shown to be formed by a line of segments, like carriages of a train. The same arrangement exists in the embryos of mammals, but is hidden in the adult mammalian brain. We will transfer our detailed knowledge of bird brains to make a maps of the brainstem segments in adult mice. We will then test this map with special gene markers which will reveal the occult segmental pattern in adult mice. This work will give us a new way of understanding the organisation of brainstem centres that control breathing, cardiovascular functions and emotional states.Read moreRead less
Towards a continuum model of orienting and defensive responses. Orienting (OR) and Defensive Responses (DR) underlie important survival functions of attending to unexpected stimuli and avoiding harm.We will establish the first integrative profile of human OR/DR function, using simultaneous recording of brain activity and 'body' responsivity. Given sex and age variation in OR/DRs, both males and females spanning six decades will be studied. OR/DR abnormalities are associated with major disorders ....Towards a continuum model of orienting and defensive responses. Orienting (OR) and Defensive Responses (DR) underlie important survival functions of attending to unexpected stimuli and avoiding harm.We will establish the first integrative profile of human OR/DR function, using simultaneous recording of brain activity and 'body' responsivity. Given sex and age variation in OR/DRs, both males and females spanning six decades will be studied. OR/DR abnormalities are associated with major disorders of attention and stress, which also vary with sex and age. We will examine relationships between OR/DR function and proneness to these disorders in healthy individuals. The results will provide a framework for developing prevention and intervention strategies.Read moreRead less
Exploring the brain mechanisms underlying hyperactivity in Attention-Deficit/Hyperactivity Disorder. Attention-deficit/Hyperactivity Disorder (AD/HD) is the most common psychiatric disorder affecting children, resulting in substantial costs (both human and financial) to the child, their family and Australian society. The outcomes of this project will provide a better foundation for understanding dysfunctional brain mechanisms in AD/HD, which is expected to lead to better diagnosis, treatment, an ....Exploring the brain mechanisms underlying hyperactivity in Attention-Deficit/Hyperactivity Disorder. Attention-deficit/Hyperactivity Disorder (AD/HD) is the most common psychiatric disorder affecting children, resulting in substantial costs (both human and financial) to the child, their family and Australian society. The outcomes of this project will provide a better foundation for understanding dysfunctional brain mechanisms in AD/HD, which is expected to lead to better diagnosis, treatment, and community support. Ultimately this will contribute to a healthy start to life for these children. This project will also demonstrate how an integrated Australian approach can lead the research agenda in both basic neuroscience, at the interface of psychology and physiology, and its applications in health.Read moreRead less
Occupant comfort, cognitive performance and task performance in wind-excited tall buildings. Strong winds are sensitive to climate change and highly unpredictable, critically affecting the design of tall buildings and our built environment. The outcomes of this research will revolutionalise current design approach for occupant comfort in wind-excited tall buildings and deliver a new generation of tall buildings that provides a comfortable living and working environment without a degradation of w ....Occupant comfort, cognitive performance and task performance in wind-excited tall buildings. Strong winds are sensitive to climate change and highly unpredictable, critically affecting the design of tall buildings and our built environment. The outcomes of this research will revolutionalise current design approach for occupant comfort in wind-excited tall buildings and deliver a new generation of tall buildings that provides a comfortable living and working environment without a degradation of work performance due to wind-induced vibration. The transfer of this knowledge from research to practice will enhance the international competitiveness of our architecture, engineering and construction professionals, boosting our involvement in major tall building projects worldwide and bringing long-term economical benefits to Australia.Read moreRead less
Adverse effects of sopite syndrome on occupants in wind-excited buildings. Current building motion design guidelines focus primarily on motion perception and complaint rates. However, wind-induced building motion can cause sopite syndrome or early onset motion sickness which adversely affects occupant wellbeing and work performance. This research aims to advance the understanding of the physiology of sopite syndrome, quantify the motion dosage that causes sopite syndrome and determine its advers ....Adverse effects of sopite syndrome on occupants in wind-excited buildings. Current building motion design guidelines focus primarily on motion perception and complaint rates. However, wind-induced building motion can cause sopite syndrome or early onset motion sickness which adversely affects occupant wellbeing and work performance. This research aims to advance the understanding of the physiology of sopite syndrome, quantify the motion dosage that causes sopite syndrome and determine its adverse effects on building occupants in real-world motion environments. This knowledge is expected to guide the formulation of building motion acceptability criteria based on safe motion exposure duration to facilitate the design of tall building that promotes population health and wellbeing and lifts work performance and productivity.Read moreRead less