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The aim of this project is to develop mathematical models and computer software capable of predicting immune responses to infection and disease. This “artificial immune system” should lead to improved vaccine design and better understanding of what causes the immune system to attack its own body, causing autoimmune disease, or fail to respond, causing immunodeficiency. This enabling science could then lead to improvements in treatment for a range of conditions of clinical importance.
Investigation Of The Roles Of Foxn1, Wnts And Autophagy In The Development And Function Of Thymic Epithelial Cells.
Funder
National Health and Medical Research Council
Funding Amount
$220,222.00
Summary
The immune system usually protects the body from infections. Occasionally, the immune system mistakenly recognises components of the body as foreign and attacks them, resulting in autoimmune diseases such as diabetes, multiple sclerosis and arthritis. An organ called the thymus is responsible for educating the immune system, and preventing autoimmune diseases. The proposed project will explore how the thymus develops, and how it teaches the immune system to ignore normal components of the body.
Development Of Autoimmune Pathologies In Response To Cancer Immunotherapies
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
Cancer immunotherapies (CIs) boost a patient’s own immune response towards cancer, providing long-term survival benefits. However, in some cases, CIs imbalance immune activity, leading to aberrant activation against self. This is observed clinically as a broad spectrum of autoimmune syndromes including those affecting the endocrine system. This study will investigate the mechanism by which endocrinopathies develop in response to CIs, offering new strategies for identifying susceptible patients.
Therapeutic Potential Of Hookworm Secreted Molecules For The Treatment Of Human Autoimmune Diseases
Funder
National Health and Medical Research Council
Funding Amount
$93,597.00
Summary
In developed countries, the increased incidence of allergic and autoimmune diseases has been related to the decreased prevalence of parasitic infections. The present research will explore the role that parasite molecules play in mechanisms that regulate the immune response of their vertebrate hosts and test their potential to become novel therapeutics for the treatment of inflammatory diseases.