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Australian Laureate Fellowships - Grant ID: FL0992409
Funder
Australian Research Council
Funding Amount
$2,996,243.00
Summary
The neural bases of decision-making. This research focuses on the neural bases of decision making, a general capacity affected by normal ageing, disorders associated with neurodegeneration including dementia, major psychiatric conditions and drug addiction. Changes in the neural systems that result in the cognitive and emotional dissociation reflected in these disorders constitute the highest health, economic and social capital attrition burden to Australia of any disease group, a burden that is ....The neural bases of decision-making. This research focuses on the neural bases of decision making, a general capacity affected by normal ageing, disorders associated with neurodegeneration including dementia, major psychiatric conditions and drug addiction. Changes in the neural systems that result in the cognitive and emotional dissociation reflected in these disorders constitute the highest health, economic and social capital attrition burden to Australia of any disease group, a burden that is only predicted to increase as the population ages. Understanding these changes in neural systems and their specific behavioural effects is, therefore, of critical importance and will ultimately provide new targets for treatment and rehabilitation.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL110100003
Funder
Australian Research Council
Funding Amount
$1,814,346.00
Summary
New directions, new problems and new data types in statistical science. Statistically challenging problems today involve answering many more questions than we have data. Solving them will elucidate the causes of diseases such as cancer, and provide better security for the community. The project will develop new methods for tackling these challenging problems, taking statistical science in new directions.
Australian Laureate Fellowships - Grant ID: FL110100196
Funder
Australian Research Council
Funding Amount
$2,638,208.00
Summary
New dimensions in organic bionics. The advent of the next generation of medical bionic devices is critically dependent on advances in multifunctional organic materials that, like living systems, provide spatial and temporal control. These advances will provide a platform to revolutionise medical treatments such as nerve and muscle regeneration, with impact on neural prosthetics.
Australian Laureate Fellowships - Grant ID: FL140100027
Funder
Australian Research Council
Funding Amount
$2,898,150.00
Summary
Under the hood: single-molecule studies of multi-protein machines. Under the hood: single-molecule studies of multi-protein machines. Living cells are filled with complex protein machines that are responsible for the molecular processes supporting life. This project is aimed towards the development of physical tools that enable the study of these protein complexes at the level of single molecules. This project aims to study the protein machinery responsible for DNA replication, the process of du ....Under the hood: single-molecule studies of multi-protein machines. Under the hood: single-molecule studies of multi-protein machines. Living cells are filled with complex protein machines that are responsible for the molecular processes supporting life. This project is aimed towards the development of physical tools that enable the study of these protein complexes at the level of single molecules. This project aims to study the protein machinery responsible for DNA replication, the process of duplicating genomic information before cell division. By making real-time single-molecule movies of the replication process, this project aims to unravel the molecular mechanisms of this important process and provide the knowledge required to understand disease mechanisms and catalyse drug development.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL160100108
Funder
Australian Research Council
Funding Amount
$2,409,738.00
Summary
How the brain creates a sense of auditory space. How the brain creates a sense of auditory space. Spatial hearing is necessary for locating the source of a sound, and critical for communication in noisy listening conditions. The object of this project is to determine how the mammalian brain, including in human listeners, represents sensitivity to interaural time differences, one of the two binaural cues, and how this representation is transformed from the brainstem to the cortex. Anticipated out ....How the brain creates a sense of auditory space. How the brain creates a sense of auditory space. Spatial hearing is necessary for locating the source of a sound, and critical for communication in noisy listening conditions. The object of this project is to determine how the mammalian brain, including in human listeners, represents sensitivity to interaural time differences, one of the two binaural cues, and how this representation is transformed from the brainstem to the cortex. Anticipated outcomes include a coherent model of binaural hearing that links cellular, systems and perceptual investigations, and an understanding of the human auditory brain that should facilitate novel technologies and interventions to improve hearing function.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL140100052
Funder
Australian Research Council
Funding Amount
$2,500,000.00
Summary
Macromolecular design for bio-imaging and targeted delivery. Macromolecular design for bio-imaging and targeted delivery. A thorough understanding of how nanoparticles interact with biological systems is imperative if advances are to be made in using nanotechnology for therapeutic applications. Fundamental aspects of nanoparticle transport, targeting and cell uptake will be investigated. This project aims to design novel nanoparticulate systems for the delivery of both an endogenous signalling ....Macromolecular design for bio-imaging and targeted delivery. Macromolecular design for bio-imaging and targeted delivery. A thorough understanding of how nanoparticles interact with biological systems is imperative if advances are to be made in using nanotechnology for therapeutic applications. Fundamental aspects of nanoparticle transport, targeting and cell uptake will be investigated. This project aims to design novel nanoparticulate systems for the delivery of both an endogenous signalling molecule and genes to cells. The project aims to inform future optimal design criteria for bespoke nanoparticle delivery systems.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL130100014
Funder
Australian Research Council
Funding Amount
$2,865,815.00
Summary
Neural and behavioural evidence for children’s learning of grammatical morphology. Children with various types of language delay have problems learning grammatical structure, leading to communicative breakdown. This project will use brain imaging and behavioural methods to understand better the nature of these problems, leading to more effective intervention, better child health and wellbeing, and improved educational outcomes.