Exploring Scanning Ultrasound (SUS), A Novel Method To Treat And Prevent Neurodegenerative Disease
Funder
National Health and Medical Research Council
Funding Amount
$765,708.00
Summary
We developed a novel scanning ultrasound (SUS) protocol that clears toxic protein aggregates and restores memory function in mouse models of Alzheimer's disease (AD), without the need for therapeutic agents. Here we aim to determine whether SUS has preventative potential, whether there are synergistic effects, and whether a therapeutic antibody combined with SUS leads to an enhanced therapeutic outcome. Together this will guide the development of an ultrasound therapy in AD patients.
Noise-free Cryogenic Wavefront Sensing. This project aims to optimise the prototype adaptive optics technology for the Giant Magellan Telescope (GMT) by leveraging past investment in adaptive optics instrumentation and shortwave infrared detector systems. This project expects to generate significant improvements in GMT performance, with ten times greater image resolution than the Hubble Space Telescope and current estimates of >90% sky coverage, compared with ~50% coverage for current technology ....Noise-free Cryogenic Wavefront Sensing. This project aims to optimise the prototype adaptive optics technology for the Giant Magellan Telescope (GMT) by leveraging past investment in adaptive optics instrumentation and shortwave infrared detector systems. This project expects to generate significant improvements in GMT performance, with ten times greater image resolution than the Hubble Space Telescope and current estimates of >90% sky coverage, compared with ~50% coverage for current technology. Expected outcomes of this project include the development of a highly trained workforce and continued international collaboration in the field of high-technology sensor systems. This contribution to the GMT will provide significant benefits—it will change the way we view the Universe.Read moreRead less
Development of large scale expansion tubes. The aim of this proposal is to develop a high Mach number scramjet simulation capability by modifying the X3 superorbital expansion tube at UQ for high suborbital operation at very high total pressures. This will enable Australia to do true Mach number simulation at higher speeds than is possible anywhere else, and mantain an international advantage in the development of scramjet flight propulsion. It will also put Australian researchers in a strong p ....Development of large scale expansion tubes. The aim of this proposal is to develop a high Mach number scramjet simulation capability by modifying the X3 superorbital expansion tube at UQ for high suborbital operation at very high total pressures. This will enable Australia to do true Mach number simulation at higher speeds than is possible anywhere else, and mantain an international advantage in the development of scramjet flight propulsion. It will also put Australian researchers in a strong position to participate in the next generation of US ground testing facilities, foreshadowed by the recent NASA purchase of a large shock tunnel driver. It will enable Australia to maintain a position of leadership in the development of new space travel concepts.Read moreRead less
Minimizing hypersonic skin-friction by boundary-layer combustion. The high drag associated with hypersonic flight has been a major obstacle to development of hypersonic aircraft. It is generally accepted that half the drag of hypersonic vehicles will be caused by air friction on the aircraft's skin, due mainly to the turbulent boundary layer which forms on the skin. However, a new method of reducing skin friction, by injecting and burning fuel in the boundary layer, has been discovered. This ....Minimizing hypersonic skin-friction by boundary-layer combustion. The high drag associated with hypersonic flight has been a major obstacle to development of hypersonic aircraft. It is generally accepted that half the drag of hypersonic vehicles will be caused by air friction on the aircraft's skin, due mainly to the turbulent boundary layer which forms on the skin. However, a new method of reducing skin friction, by injecting and burning fuel in the boundary layer, has been discovered. This project is aimed at investigating the range of conditions under which this method will be effective. By this boundary-layer "lubrication" much more efficient hypersonic flight will be possible.Read moreRead less
Enhancing scramjet performance by boundary layer combustion. Australia has developed a strong international reputation over the past 20 years for excellence in research into hypersonic flight technologies. This helps to reinforce the fact that this is a country in which advanced technologies can be conceived and developed. Australian companies and agencies are already collaborating with and are being supported by international organizations to develop further hypersonic flight technologies. Achi ....Enhancing scramjet performance by boundary layer combustion. Australia has developed a strong international reputation over the past 20 years for excellence in research into hypersonic flight technologies. This helps to reinforce the fact that this is a country in which advanced technologies can be conceived and developed. Australian companies and agencies are already collaborating with and are being supported by international organizations to develop further hypersonic flight technologies. Achieving another significant advance in this area by demonstrating significant reductions in frictional drag on hypersonic vehicles will keep us at the forefront of this field and lead to continued international support and collaboration.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100111
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
A database for Australian optical astronomy. We will build an astronomy data facility to provide database facilities to analyse data from three major Australian optical astronomy projects, SkyMapper, WiggleZ and GAMA. The facility will provide efficient analysis tools not only for the researchers immediately involved with the projects, but, for the entire national and international astronomical community when the data become public. Long-term maintenance of the facility is vital, so the facilit ....A database for Australian optical astronomy. We will build an astronomy data facility to provide database facilities to analyse data from three major Australian optical astronomy projects, SkyMapper, WiggleZ and GAMA. The facility will provide efficient analysis tools not only for the researchers immediately involved with the projects, but, for the entire national and international astronomical community when the data become public. Long-term maintenance of the facility is vital, so the facility will be standards-compliant and stable to facilitate long-term support. For this reason the facility will be based at the ANU Supercomputer Facility (ANUSF) to leverage substantial expertise in this area and to provide long-term operations support.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100087
Funder
Australian Research Council
Funding Amount
$760,000.00
Summary
Veloce - Australia's Next-Generation Planet Foundry. Veloce - Australia's next-generation planet foundry: This project will deliver to Australian astronomers a high-resolution, ultra-stabilised, red-wavelength-optimised spectrograph capable of delivering high-precision doppler velocities for the transiting exoplanet host-stars being discovered now by southern hemisphere transit-planet searches, and for the coming wave of discoveries to be made by NASA's Transiting Exoplanet Survey Satellite (TES ....Veloce - Australia's Next-Generation Planet Foundry. Veloce - Australia's next-generation planet foundry: This project will deliver to Australian astronomers a high-resolution, ultra-stabilised, red-wavelength-optimised spectrograph capable of delivering high-precision doppler velocities for the transiting exoplanet host-stars being discovered now by southern hemisphere transit-planet searches, and for the coming wave of discoveries to be made by NASA's Transiting Exoplanet Survey Satellite (TESS). In addition it will enable a vast suite of new research programs in exoplanetary science and galactic archaeology, as well as providing a sound base of ultra-stable infrastructure enabling future expansion to cover the full optical wavelength range at minimal cost.Read moreRead less