Glucocorticoid Resistance: Identifying New Anti-inflammatory Drug Targets
Funder
National Health and Medical Research Council
Funding Amount
$453,287.00
Summary
The control of chronic inflammatory diseases such as asthma involve use of drugs related to the steroid hormone cortisol. Up to 40% of patients with more severe disease respond poorly or not at all to these drugs. The remaining non-steroid treatments are only partially effective. Poor disease control is a great health and economic burden. We have identified a molecular mechanism for steroid resistance and propose new studies to identify novel drugs that act to reverse steroid resistance.