Epidemiological Investigation Of The Role Of Early Life Environment In The Development Of Immune Function And Allergic And Autoimmune Disease: Knowledge Generation For Future Primary Prevention.
Funder
National Health and Medical Research Council
Funding Amount
$664,584.00
Summary
Immune diseases, which include allergic and autoimmune diseases, are accounting for an increasing fraction of the disease burden in Australia. It is now increasingly recognised that early life changes to the immune system by environmental factors can impact on the risk of these diseases. The goal of this fellowship is the prevention of allergic and autoimmune disease.
Early Life Exposures And Chronic Disease: Mechanisms And Preventative Strategies
Funder
National Health and Medical Research Council
Funding Amount
$851,980.00
Summary
The world is facing an epidemic of chronic disease and adverse environmental exposures in early life are partly responsible. One reason why we have not been able to do more to prevent this is the lack of appropriate methods for measuring environmental exposures during pregnancy and infancy. My research will develop and validate methods for measuring exposures early life and the health consequences of these exposures with the aim of developing preventative interventions
Allergies and chronic respiratory diseases are major causes of illness and death in Australia. Worryingly there are still many gaps in knowledge on how best to prevent and manage these diseases. The proposed program will investigate these questions and provide evidence to guide health policy and clinical management. As this program is built on state-of the-art methods and technology, these original Australian findings will be of great importance internationally.
Improving Outcomes In Pregnancies Complicated By Asthma: Understanding Mechanisms And Defining Interventions
Funder
National Health and Medical Research Council
Funding Amount
$707,370.00
Summary
Asthma is a common disease to complicate pregnancy and it is important to identify ways of effectively managing the disease to ensure the fetus has the best possible outcome. The current research focusses on this disease and looks at ways of improving management in pregnancy and improving outcomes for the baby.
Delivering On The GWAS Promise: From Genetic Discoveries To Novel Drug Targets For Asthma
Funder
National Health and Medical Research Council
Funding Amount
$697,605.00
Summary
The aim of this study is to identify new drug targets for asthma. This is important because for 6 in 10 asthma patients, current treatments do not adequately control disease symptoms and so these individuals are at a higher risk of having severe exacerbations. I propose that identifying asthma risk genes represents our best chance to identify novel drug targets for asthma. In this study, I will identify new asthma risk genes and test whether blocking these genes can alleviate disease symptoms.
My work focuses on the prevention of vascular disease. A major aim of mine is to improve outcome after stroke. We can test this by assessing whether individualised management plans provided to people with stroke will improve risk factors. Proper risk factor management reduces the risk of stroke recurrence. I also aim to reduce the burden of vascular disease in disadvantaged settings by finding out what risk factors are important in the development of these diseases in people living in poverty.
Through the improved understanding of the determinants of road injury, the identification of effective and efficient preventive strategies and how best to translate the research findings, this Fellowship will facilitate reductions in the burden of road injury in Australia.
Research Fellowship In Preventing HIV And HIV-related Cancer
Funder
National Health and Medical Research Council
Funding Amount
$772,490.00
Summary
This fellowship concerns HIV prevention and HIV-related cancer. In HIV prevention, Grulich will evaluate the success of elements of the new biomedical prevention approach to HIV, and highlight areas in which policy action can be taken to substantially reduce HIV transmission. In HIV related cancer, Grulich will determine whether HIV-associated cancers continue to occur at increased rates in the new era of prolonged survival of people with HIV, and investigate preventive approaches.
Inflammatory Airway Diseases In Children: Mechanisms Underlying And Preventative Strategies
Funder
National Health and Medical Research Council
Funding Amount
$823,008.00
Summary
Professor Sly’s research concentrates on understanding why some children develop chronic lung disease and on finding ways to prevent this from happening.
Development Of New Therapies For Respiratory Diseases And Infection
Funder
National Health and Medical Research Council
Funding Amount
$847,490.00
Summary
Prof Hansbro’s group have developed world 1st experimental models of emphysema, severe asthma infection and lung cancer. He uses them to further our understanding of these untreatable diseases. This has led to the development of new potential therapeutic approaches. Now, in discovery programs he will expand studies of pathogenesis to identify new therapeutic targets these diseases. In development and translational programs he will progress new therapies towards clinical application.