Inhibitors of meso-diaminopimelic acid (meso-DAP) and lysine biosynthesis: targeting dihydrodipicolinate synthase. With antibiotic resistance on the rise, there is an urgent need to develop new antibiotics with novel modes of action. This project aims to generate new drug candidates that target dihydrodipicolinate synthase (DHDPS) - the first enzyme in the synthesis of the bacterial cell wall - using a triple-pronged approach. This novel approach will allow for the development of new drugs to tr ....Inhibitors of meso-diaminopimelic acid (meso-DAP) and lysine biosynthesis: targeting dihydrodipicolinate synthase. With antibiotic resistance on the rise, there is an urgent need to develop new antibiotics with novel modes of action. This project aims to generate new drug candidates that target dihydrodipicolinate synthase (DHDPS) - the first enzyme in the synthesis of the bacterial cell wall - using a triple-pronged approach. This novel approach will allow for the development of new drugs to treat a range of pathogenic bacteria, including "Golden Staph".Read moreRead less
The Development of Novel Task Specific and Biodegradable Ionic Liquids. The advance of ?Green Chemistry? has become a forefront issue in mainstream chemistry. Green Chemistry is aimed at the reduction or elimination of hazardous substances in the design, manufacture and application of chemical products. The advent of ionic liquids (ILs) has made a significant contribution towards these goals. ILs have many beneficial properties including non-volatility, non-flammability, and a large stable liq ....The Development of Novel Task Specific and Biodegradable Ionic Liquids. The advance of ?Green Chemistry? has become a forefront issue in mainstream chemistry. Green Chemistry is aimed at the reduction or elimination of hazardous substances in the design, manufacture and application of chemical products. The advent of ionic liquids (ILs) has made a significant contribution towards these goals. ILs have many beneficial properties including non-volatility, non-flammability, and a large stable liquid range. As ILs advance from academic curiosities to industrial solvents, the need to address the issue of their biodegradability and toxicity is paramount. The key objective of this project is to design new biodegradable and task specific ILs for environmentally friendly industrial use.Read moreRead less