Prevalence Of Dementia In The Torres Strait And Common Health Issues Of Later Life In The Torres Strait
Funder
National Health and Medical Research Council
Funding Amount
$365,000.00
Summary
The aim of the project is to assess the prevalence of dementia in people aged 45 years and over living in Torres Strait Islander communities and identify potential risk and protective factors associated with dementia risk. An additional aim is to revalidate a culturally appropriate cognitive assessment tool, the Kimberley Indigenous Cognitive Assessment (KICA) for use in the Torres Strait.
SCALE-C: Strategies For Hepatitis C Testing And Treatment In Aboriginal Communities That Lead To Elimination
Funder
National Health and Medical Research Council
Funding Amount
$2,175,170.00
Summary
Prevalence of hepatitis C infection within the Aboriginal population is among the highest of any identifiable population in Australia. Highly effective, direct-acting antiviral (DAA) therapy, and their listing on the PBS in 2016 has revolutionised HCV clinical management in Australia. The SCALE-C study will evaluate an established test and treat model to rapidly scale-up DAA within four Aboriginal communities to determine both impact on community prevalence and ongoing transmission.
Evaluation Of SCID-I In The Diagnosis Of Mental Disorders In Indigenous Australians
Funder
National Health and Medical Research Council
Funding Amount
$988,007.00
Summary
Current estimates of mental disease among Indigenous Australians are inadequate. This research will examine the use of a structured interview tool that is promoted globally for diagnosing mental disorders, and then use the tool to quantify the burden of mental illness among Indigenous Australians. The findings will provide accurate estimates of occurrence of mental disorders, thereby help inform policy making and planning of services for Indigenous Australians.
Understanding How Azithromycin Prevents Exacerbations In Severe Asthma
Funder
National Health and Medical Research Council
Funding Amount
$697,273.00
Summary
In some people with severe asthma, conventional inhaler treatments are not able to control the disease so there is a need for new treatment options. We have recently completed a large clinical trial which showed that very low doses of a common antibiotic help prevent asthma attacks in this situation. However, not much is known about how the antibiotic is working. This study will help us understand how the antibiotic is working and which people respond best.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100035
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Hyperpolarised gas functional lung and molecular imaging. This project will produce a polariser to generate magnetised gas for research with magnetic resonance imaging (MRI). This allows imaging of normal and abnormal lung ventilation and circulation in animal and humans. The use of these hyperpolarised gases can also be used to tag specific molecules and increase understanding of lung metabolism.
Investigations into and development of an intelligent decision support system for general practitioners in home-based sleep disorder diagnosis. Sleep disorders cost the Australian health system an estimated $40 million per year. General practitioner's surgeries are not well equipped to deal with diagnosis and the majority of the referrals to specialists are unnecessary. This research will investigate and develop an intelligent decision support system to provide a cost effective solution to thi ....Investigations into and development of an intelligent decision support system for general practitioners in home-based sleep disorder diagnosis. Sleep disorders cost the Australian health system an estimated $40 million per year. General practitioner's surgeries are not well equipped to deal with diagnosis and the majority of the referrals to specialists are unnecessary. This research will investigate and develop an intelligent decision support system to provide a cost effective solution to this problem. The developed software application will enable sleep study to be carried out at home, enabling general practitioners to conduct a preliminary diagnosis. Benefits include a reduction in the costs incurred in travel, time off work and at hospital sleep care centres for people in remote areas.Read moreRead less
New Insights Into Viral Inflammatory Disease Mechanisms And Approaches To Therapy
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This fellowship aims to establish how viruses cause disease, including how they evade the immune response to persist and cause disease for prolonged periods. My vision is that knowing how the virus and the immune system interact to determine disease severity will assist in devising new treatments and prevention programs to lessen the impact of viral diseases in Australia and worldwide.
Rhinovirus impairs physiological and immunological lung development and causes exacerbation of allergic airways disease. Rhinovirus (RV) infections account for around 90 per cent of asthma exacerbations, yet the mechanisms behind this are unknown. This project will use mouse models to study the effects of early life RV infection and allergic sensitisation on respiratory and immunological development, with the expectation that early life RV infection disrupts anitgen presenting cell function.
Towards an influenza virus glycan interaction map (Glycointeractome). This project will use nuclear magnetic resonance (NMR) spectroscopy to map carbohydrate interaction used by the virus to cause infection and spread. This information will provide new direction in anti-influenza drug discovery.
Impaired innate antiviral immunity predisposes toward virus-associated airway remodelling in childhood asthma. Increased airway smooth muscle (ASM) mass is the major pathological feature of asthma that causes poor lung function. ASM remodelling occurs in early life, is refractory to current treatments and persists into later life. Severe respiratory virus infections in early life are a major risk factor for the development of asthma, yet it remains to be determined whether viruses promote ASM re ....Impaired innate antiviral immunity predisposes toward virus-associated airway remodelling in childhood asthma. Increased airway smooth muscle (ASM) mass is the major pathological feature of asthma that causes poor lung function. ASM remodelling occurs in early life, is refractory to current treatments and persists into later life. Severe respiratory virus infections in early life are a major risk factor for the development of asthma, yet it remains to be determined whether viruses promote ASM remodelling. Previous studies have developed a unique mouse model of childhood asthma and discovered the molecular mechanism by which this tissue tropism develops in response to virus infection. This project will identify new targets for immunomodulation and design new biologics to block ASM remodelling and the deleterious effects of respiratory virus infection in asthmatic subjects. Read moreRead less