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Identification of structural proteins in the tissue cyst wall of Toxoplasma gondii. Most infections with Toxoplasma gondii are asymptomatic, however, infection during pregnancy can lead to miscarriage or blindness, deafness and mental retardation in the developing baby. Furthermore, in AIDS patients, toxoplasmosis is the leading cause of fatal encephalitis as the normally dormant tissue cysts are reactivated in the absence of an effective immune system. In Australia, it has been estimated that ~ ....Identification of structural proteins in the tissue cyst wall of Toxoplasma gondii. Most infections with Toxoplasma gondii are asymptomatic, however, infection during pregnancy can lead to miscarriage or blindness, deafness and mental retardation in the developing baby. Furthermore, in AIDS patients, toxoplasmosis is the leading cause of fatal encephalitis as the normally dormant tissue cysts are reactivated in the absence of an effective immune system. In Australia, it has been estimated that ~30% of the population is infected with T. gondii and the occurrence of congenital toxoplasmosis is 0.2% of live births, which translates to roughly 500 cases/year. Our research will identify structural proteins in Toxoplasma cyst walls that will lead to the design of new strategies to control the diseases caused by these parasites.Read moreRead less
Matched experiments and numerical simulations of flow-induced oscillations in uniform and tapered-stiffness collapsible tubes. Flexible tubes that can be flattened are widespread in the body and can act to limit flow-rate. Limitation is usually associated with spontaneous oscillation (repetitive opening and closing). There are many candidate explanations, but none has been shown to correspond with a given experiment. Through computer models and matched experiments on this coupled system (the ....Matched experiments and numerical simulations of flow-induced oscillations in uniform and tapered-stiffness collapsible tubes. Flexible tubes that can be flattened are widespread in the body and can act to limit flow-rate. Limitation is usually associated with spontaneous oscillation (repetitive opening and closing). There are many candidate explanations, but none has been shown to correspond with a given experiment. Through computer models and matched experiments on this coupled system (the fluid flow interacts with the tube shape), we seek to demonstrate for the first time that a given theory/computer model encompasses the physics controlling a given observed oscillation. The solution will find application in other flexible-structure design problems in engineering, and also potentially in medicine.Read moreRead less
Degradation of Trace Contaminants Using Sonochemistry and Peroxide Scavenging Advanced Oxidation Processes. Sonochemical degradation of hazardous organic compounds in aqueous solution has been examined extensively in recent years and found to be an effective means of waste treatment however the scavenging of hydroxyl radicals by the relatively high concentrations of hydrogen peroxide produced limits the amount of reactive radicals accessible to target molecules. In this project we will investiga ....Degradation of Trace Contaminants Using Sonochemistry and Peroxide Scavenging Advanced Oxidation Processes. Sonochemical degradation of hazardous organic compounds in aqueous solution has been examined extensively in recent years and found to be an effective means of waste treatment however the scavenging of hydroxyl radicals by the relatively high concentrations of hydrogen peroxide produced limits the amount of reactive radicals accessible to target molecules. In this project we will investigate, by both experimental and computational means, options for the regeneration of hydroxyl radicals through use of hydrogen peroxide. Methods of particular interest include use of Fenton's reagent and ozone.Read moreRead less
Drying sewage sludge using hot oil. The project seeks to investigate and develop an entirely new area of fundamental and applied research involving the process, mechanisms and kinetics of direct dehydration of sewage sludge by fry-drying in hot oil. Frying can be carried out as a drying process, though it not widely recognized or applied in this way, and has consequently not been exploited outside of the traditional food industries. It potentially provides a wide range of significant benefits ....Drying sewage sludge using hot oil. The project seeks to investigate and develop an entirely new area of fundamental and applied research involving the process, mechanisms and kinetics of direct dehydration of sewage sludge by fry-drying in hot oil. Frying can be carried out as a drying process, though it not widely recognized or applied in this way, and has consequently not been exploited outside of the traditional food industries. It potentially provides a wide range of significant benefits for sludge drying, including high efficiency and low costs, and produces a non-offensive product with a high energy value suitable for (renewable) power generation.Read moreRead less
Establishing the relationship between water characteristics and fouling of membranes used in water reuse. The project will result in the following significant benefits to the Australian and international partners: a state-of-the-art laboratory and semi-pilot system from which a full-scale system could be developed and tested, funded by the water industry; an outstanding research project for postgraduate students at the University of Technology, Sydney (UTS), Gwangji Institute of Science and Tech ....Establishing the relationship between water characteristics and fouling of membranes used in water reuse. The project will result in the following significant benefits to the Australian and international partners: a state-of-the-art laboratory and semi-pilot system from which a full-scale system could be developed and tested, funded by the water industry; an outstanding research project for postgraduate students at the University of Technology, Sydney (UTS), Gwangji Institute of Science and Technology, Korea (GIST) and Yale University; and fostering a culture of innovation in the wastewater industry in Australia, Korea and USA and contributing to the commercialization of research by UTS, GIST and YU.Read moreRead less
An innovative wastewater treatment system for the removal of persisting organic pollutants (POPs). Photocatalysis is an emerging technology in wastewater treatment that is capable of completely converting POPs into harmless compounds. In this research, we will combine the expertise of Gwangju Institute of Science and Technology (GIST) in water reuse technologies, and Chonnam National University (CNU) in advanced oxidation processes with that of UTS' in physico-chemical treatment processes to dev ....An innovative wastewater treatment system for the removal of persisting organic pollutants (POPs). Photocatalysis is an emerging technology in wastewater treatment that is capable of completely converting POPs into harmless compounds. In this research, we will combine the expertise of Gwangju Institute of Science and Technology (GIST) in water reuse technologies, and Chonnam National University (CNU) in advanced oxidation processes with that of UTS' in physico-chemical treatment processes to develop a novel photocatalysis hybrid system. Through long term collaboration we aim to: (i) establish an innovative hybrid system for POPs removal, (ii) prepare industry grants, (iii) research training of postgraduate research students, and (iv) help to commercialize our research outcomes for domestic benefit and export.Read moreRead less
A better way to remove arsenic from drinking water. Arsenic is a serious pollutant of drinking water in parts of Australia and in Asia, We propose to developed an inovative technology to remove arsenic from water. Our international partnership combines the expertise of the University of Regina (UR), Canada in physico-chemical treatment processes with that of the UTS in membrane processes. Through a long term collaboration we aim to: (i) establish a full-scale innovative system for arsenic remova ....A better way to remove arsenic from drinking water. Arsenic is a serious pollutant of drinking water in parts of Australia and in Asia, We propose to developed an inovative technology to remove arsenic from water. Our international partnership combines the expertise of the University of Regina (UR), Canada in physico-chemical treatment processes with that of the UTS in membrane processes. Through a long term collaboration we aim to: (i) establish a full-scale innovative system for arsenic removal, (ii) prepare joint publications and apply for more industry grants, (iii) research training of postgraduate research student, and (iv) help to commercialize our research outcomes for domestic benefit and export.Read moreRead less
Development of a novel filtration hybrid system in wastewater treatment and reuse. Water industries in Australia and Japan are aiming at developing compact wastewater treatment and reuse systems. This project will form the basis for a long-term study on coupling a new static floccuator/filter system being developed at UTS and a hanging sponge cubes bioreactor being developed at NUT. A properly designed physico-chemical biological hybrid system will be cost-effective in removing a wide range of ....Development of a novel filtration hybrid system in wastewater treatment and reuse. Water industries in Australia and Japan are aiming at developing compact wastewater treatment and reuse systems. This project will form the basis for a long-term study on coupling a new static floccuator/filter system being developed at UTS and a hanging sponge cubes bioreactor being developed at NUT. A properly designed physico-chemical biological hybrid system will be cost-effective in removing a wide range of pollutants with little maintenance. This study will establish a rational hybrid system through detailed bench and pilot-scale experimentation. It will make the optimum use of the complementary expertise and facilities at NUT and UTS.Read moreRead less
Nanofiltration in Wastewater treatment for Reuse: Effect of Pretreatment for Long-term Application. Low pressure nanofiltration (NF) is a relatively new technology. The main problem of membrane fouling on NF could successfully be avoided by pretreatment. In this study, novel high rate pretreatment methods employing flocculation and biosorption concepts will be investigated to prolong membrane life time. A compact wastewater treatment technology established through this research will be useful in ....Nanofiltration in Wastewater treatment for Reuse: Effect of Pretreatment for Long-term Application. Low pressure nanofiltration (NF) is a relatively new technology. The main problem of membrane fouling on NF could successfully be avoided by pretreatment. In this study, novel high rate pretreatment methods employing flocculation and biosorption concepts will be investigated to prolong membrane life time. A compact wastewater treatment technology established through this research will be useful in small and isolated communities. This study will be conducted in collaboration with Prof. Yamamoto of University of Tokyo (UTokyo), Japan and Prof. Kim of Kwangju Institute of Science and Technology (KJIST), Korea, who are international experts on nanofiltration and water reuse technologies respectively.Read moreRead less
Inhibitors of meso-diaminopimelic acid (meso-DAP) and lysine biosynthesis: targeting dihydrodipicolinate synthase. With antibiotic resistance on the rise, there is an urgent need to develop new antibiotics with novel modes of action. This project aims to generate new drug candidates that target dihydrodipicolinate synthase (DHDPS) - the first enzyme in the synthesis of the bacterial cell wall - using a triple-pronged approach. This novel approach will allow for the development of new drugs to tr ....Inhibitors of meso-diaminopimelic acid (meso-DAP) and lysine biosynthesis: targeting dihydrodipicolinate synthase. With antibiotic resistance on the rise, there is an urgent need to develop new antibiotics with novel modes of action. This project aims to generate new drug candidates that target dihydrodipicolinate synthase (DHDPS) - the first enzyme in the synthesis of the bacterial cell wall - using a triple-pronged approach. This novel approach will allow for the development of new drugs to treat a range of pathogenic bacteria, including "Golden Staph".Read moreRead less