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Raman spectroscopy and imaging of natural and synthetic melanins. The national benefit of this research lies in three main areas. First, this research could lead to a non-invasive diagnostic for melanoma. Second, it could reveal stronger connections between melanin and melanoma development than previously believed and thus inspire possible methods of treatment or prevention of melanoma. Given Australia's high incidence of melanoma, these could have an enormous impact on our health care system. T ....Raman spectroscopy and imaging of natural and synthetic melanins. The national benefit of this research lies in three main areas. First, this research could lead to a non-invasive diagnostic for melanoma. Second, it could reveal stronger connections between melanin and melanoma development than previously believed and thus inspire possible methods of treatment or prevention of melanoma. Given Australia's high incidence of melanoma, these could have an enormous impact on our health care system. Third, it will increase our understanding of the melanin pigment and further establish Australia as a leader in this field. Given the links between melanin and Parkinson's Disease and immune response, this understanding could have greater impact on health care than simply melanoma.Read moreRead less
CHAMP GPS-Altimetry. The proposed research project aims to develop a novel application for the Global Positioning System (GPS), namely the use of GPS signals reflected from sea- or ice-surfaces and received by Low-Earth-Orbiter (LEO) for determination of these surface heights. Data from the German satellite CHAMP will be used for this purpose, for selected regions in Antartica. CHAMP covers areas not visited by other remote sensing satellites. The Fellow is instrumental for obtaining and process ....CHAMP GPS-Altimetry. The proposed research project aims to develop a novel application for the Global Positioning System (GPS), namely the use of GPS signals reflected from sea- or ice-surfaces and received by Low-Earth-Orbiter (LEO) for determination of these surface heights. Data from the German satellite CHAMP will be used for this purpose, for selected regions in Antartica. CHAMP covers areas not visited by other remote sensing satellites. The Fellow is instrumental for obtaining and processing these CHAMP data.
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Investigation of novel sialic acid mimetics to target the spread of cancer. The mortality rates for many cancers afflicting the world's population are extremely high and these rates are consistent with the Australian experience. It is generally accepted that colon cancer, and cancers as a whole, are a significant healthcare issue and have immense socioeconomic impact. Alternative treatments preventing the spread of cancers would be of very significant benefit. This fellowship will provide the ....Investigation of novel sialic acid mimetics to target the spread of cancer. The mortality rates for many cancers afflicting the world's population are extremely high and these rates are consistent with the Australian experience. It is generally accepted that colon cancer, and cancers as a whole, are a significant healthcare issue and have immense socioeconomic impact. Alternative treatments preventing the spread of cancers would be of very significant benefit. This fellowship will provide the opportunity for the discovery and development of such treatments that are based on the processes that utilise carbohydrates to facilitate the spread of tumours.Read moreRead less
Design and evaluation of new environmentally-benign herbicides that inhibit branched-chain amino acid biosynthesis. Herbicides interfere with processes that occur in plants, such as photosynthesis or the biosynthesis of certain amino acids. In this project we will focus on branched-chain amino acid biosynthesis, designing and evaluating inhibitors of the first two enzymes in this process. Based on their three dimensional structures we will develop an understanding of the molecular features that ....Design and evaluation of new environmentally-benign herbicides that inhibit branched-chain amino acid biosynthesis. Herbicides interfere with processes that occur in plants, such as photosynthesis or the biosynthesis of certain amino acids. In this project we will focus on branched-chain amino acid biosynthesis, designing and evaluating inhibitors of the first two enzymes in this process. Based on their three dimensional structures we will develop an understanding of the molecular features that contribute to a potent inhibitor and those that are required for it to be effective upon plants. Using this information we will design and synthesis new compounds as potential environmentally-benign herbicides.Read moreRead less