Role Of Musculoskeletal Biomechanical Factors In Cartilage Loss In Those Who Undergo Partial Medial Menisectomy.
Funder
National Health and Medical Research Council
Funding Amount
$654,530.00
Summary
The novel outcomes from our project are that we will identify whether musculoskeletal-biomechanical factors that can be modified are associated with adverse cartilage changes in a subgroup of individuals with an increased risk of developing knee OA, those who have undergone an APM. The findings of this research are timely and of major international significance as there is increasing attention being paid to preventing OA rather than merely treating the signs and symptoms. Our state-of-the-art me ....The novel outcomes from our project are that we will identify whether musculoskeletal-biomechanical factors that can be modified are associated with adverse cartilage changes in a subgroup of individuals with an increased risk of developing knee OA, those who have undergone an APM. The findings of this research are timely and of major international significance as there is increasing attention being paid to preventing OA rather than merely treating the signs and symptoms. Our state-of-the-art measure of cartilage changes will allow us to detect those at risk much sooner than traditional measures using radiographs. The measures are also leading edge internationally. We chose these specific factors to investigate as there is evidence that they can be modified with appropriate interventions. For example, static joint alignment could be modified with foot orthoses [Crenshaw, 2000 #1016], muscle weakness can be addressed with strength programs and mechanical loading across the knee could be reduced via weight loss programs or techniques to alter gait patterns. Currently, formal supervised post-operative rehabilitation is not routinely prescribed following APM because it is considered a routine procedure. If our research identifies risk factors for increased cartilage loss then we will be able to develop appropriate intervention strategies for individuals following an APM. These interventions can then be formally tested as to their effectiveness in reducing adverse cartilage changes using randomised controlled trials. In particular, this could lead to changes in current post-operative clinical practice for this patient group. Ultimately, this could reduce the risk of OA in the future and the resultant personal and societal costs of this condition.Read moreRead less
Variational theory for fully nonlinear elliptic equations. This project aims to develop new methods and techniques to solve challenging mathematical problems in fully nonlinear partial differential equations arising in important applications. The project will develop methods and techniques to study these equations’ regularity and variational properties. This project is expected to establish comprehensive theories and enhance and promote Australian participation and leadership in this area of mat ....Variational theory for fully nonlinear elliptic equations. This project aims to develop new methods and techniques to solve challenging mathematical problems in fully nonlinear partial differential equations arising in important applications. The project will develop methods and techniques to study these equations’ regularity and variational properties. This project is expected to establish comprehensive theories and enhance and promote Australian participation and leadership in this area of mathematics.Read moreRead less
Non-linear partial differential equations: Bubbles, layers and stability. This project aims to investigate non-linear elliptic partial differential equations in well-established models in applied sciences. The treatment of them challenges the existing mathematical theory. This project will enrich and expand the mathematical theory in semi-linear elliptic equations to understand the equations under investigation.
New perspectives on nonlocal equations. This project aims at tackling cutting-edge problems in the field of mathematical analysis, with specific focus on nonlocal equations, by introducing innovative approaches and a unified perspective. It focuses on the use of long-range interactions to deeply understand new effects arising in several mathematical problems of great impact.
The research will be performed through stimulating international collaborations, providing exchange opportunities and idea ....New perspectives on nonlocal equations. This project aims at tackling cutting-edge problems in the field of mathematical analysis, with specific focus on nonlocal equations, by introducing innovative approaches and a unified perspective. It focuses on the use of long-range interactions to deeply understand new effects arising in several mathematical problems of great impact.
The research will be performed through stimulating international collaborations, providing exchange opportunities and ideal conditions for students to complete their training.
The expected outcomes include new techniques to solve difficult problems, high impact international research collaborations, training of the next generation of mathematicians and top tier journal publications.Read moreRead less
Singularity and regularity for Monge-Ampere type equations. The Monge-Ampere equation, as a premier nonlinear partial differential equation, arises in several areas including geometry, physics, and optimal transportation. Many important problems and applications are related to the regularity of solutions, which are obstructed by singularities. This project aims to classify the geometry of the singular sets, and to establish a comprehensive regularity theory for general Monge-Ampere type equation ....Singularity and regularity for Monge-Ampere type equations. The Monge-Ampere equation, as a premier nonlinear partial differential equation, arises in several areas including geometry, physics, and optimal transportation. Many important problems and applications are related to the regularity of solutions, which are obstructed by singularities. This project aims to classify the geometry of the singular sets, and to establish a comprehensive regularity theory for general Monge-Ampere type equations by using innovative approaches and developing cutting-edge technologies in partial differential equations. Expected outcomes include the resolution of outstanding open problems. This project will significantly enhance Australia’s leadership and expertise in a major area of mathematics and applications.Read moreRead less
Propagation described by partial differential equations with free boundary. Cutting edge nonlinear mathematics is required to understand many important propagation phenomena in nature, such as the spreading of invasive species or nerve signals. This project aims to systematically investigate nonlinear partial differential equation models that govern the dynamics of such propagations, with emphasis on the development of new approaches that enable deeper insights on the evolution of the propagatin ....Propagation described by partial differential equations with free boundary. Cutting edge nonlinear mathematics is required to understand many important propagation phenomena in nature, such as the spreading of invasive species or nerve signals. This project aims to systematically investigate nonlinear partial differential equation models that govern the dynamics of such propagations, with emphasis on the development of new approaches that enable deeper insights on the evolution of the propagating fronts. The project aims to develop new mathematics for new applications of lasting values.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230101165
Funder
Australian Research Council
Funding Amount
$419,420.00
Summary
Geometric Scattering Theory, Resolvent Estimates, and Wave Asymptotics. This project aims to understand how fast the local energy of a wave decays when it propagates in a rough, open system. This projects will generate new knowledge in the mathematical subfields of microlocal analysis and partial differential equations by refining tools such as Carleman estimates, separation of variables, b-vector field analysis, and quasimode constructions. The expected outcome of this project is a novel and co ....Geometric Scattering Theory, Resolvent Estimates, and Wave Asymptotics. This project aims to understand how fast the local energy of a wave decays when it propagates in a rough, open system. This projects will generate new knowledge in the mathematical subfields of microlocal analysis and partial differential equations by refining tools such as Carleman estimates, separation of variables, b-vector field analysis, and quasimode constructions. The expected outcome of this project is a novel and comprehensive mathematical treatment of wave propagation in systems with weaker than Lipschitz regularity. This research should provide significant benefits such as informing predictions about waves in rough systems, including the propagation of seismic waves, and lead to advances in medical and geological imaging.Read moreRead less