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Ross River virus - identification of virulence determinants in clinical isolates from across Australia. In Australia, Ross River virus (RRV) is the most common insect borne virus that affects human health. There were more than 60,000 confirmed cases of RRV between 1993 and 2008. While not fatal, the disease is responsible for significant morbidity that has both social and economic costs for the individual, their family and the community. The project has several national benefits. It will elucida ....Ross River virus - identification of virulence determinants in clinical isolates from across Australia. In Australia, Ross River virus (RRV) is the most common insect borne virus that affects human health. There were more than 60,000 confirmed cases of RRV between 1993 and 2008. While not fatal, the disease is responsible for significant morbidity that has both social and economic costs for the individual, their family and the community. The project has several national benefits. It will elucidate whether there is any association between RRV strain and the severity of human disease. It will also identify viral markers that could assist public health officials in determining likely disease outcomes of outbreaks and could provide new avenues for the design of antiviral strategies.Read moreRead less
Development and characterization of a technology platform to study the mechanisms of scaffold/Bone Morphogenic Proteins (BMP) augmented large segmental bone healing. This project will increase understanding of bone engineering and in doing so will lead to superior treatments for bone defects. Such a treatment would be valuable in addressing the ever-increasing problems of diminished productivity and reduced quality of life associated with bone disorders as the population ages. The multidisciplin ....Development and characterization of a technology platform to study the mechanisms of scaffold/Bone Morphogenic Proteins (BMP) augmented large segmental bone healing. This project will increase understanding of bone engineering and in doing so will lead to superior treatments for bone defects. Such a treatment would be valuable in addressing the ever-increasing problems of diminished productivity and reduced quality of life associated with bone disorders as the population ages. The multidisciplinary and international team will be valuable in establishing Australia's prominence in this field and training the next generation of young scientists and engineers. The technologies developed will be of great interest to a large number of research groups and companies worldwide and will assist with fostering international collaboration and placing Australia at the forefront of this emerging field.Read moreRead less
Refinement And Delivery Of Synthetic Compounds That Specifically Alter Muscle Contraction. The project has broad benefits for the nation and the community. Cutting edge research at the molecular level, done within Australia, will benefit Australian scientists and research in general. The discovery of drugs that will be developed by the Australian Pharmaceutical Industry will benefit the Australian Industry sector and will have spin-offs for the racing industry, livestock industry (lean meat) an ....Refinement And Delivery Of Synthetic Compounds That Specifically Alter Muscle Contraction. The project has broad benefits for the nation and the community. Cutting edge research at the molecular level, done within Australia, will benefit Australian scientists and research in general. The discovery of drugs that will be developed by the Australian Pharmaceutical Industry will benefit the Australian Industry sector and will have spin-offs for the racing industry, livestock industry (lean meat) and for rural industry (insecticides). In addition, expansion of the outcomes of the project into preclinical development will strengthen the Australian bioscience sector. Thus the project will eventually benefit the Australian industry sector. The project will have further benefits for education and training. Read moreRead less
The role of muscle and tendon mechanics in human muscle damage. This project aims to examine what sort of forceful stretch is required to cause exercise induced muscle damage (EIMD) in humans and how muscles adapt to limit future damage. Specifically, the project aims to examine how the elastic properties of tendons might reduce muscle damage by buffering stretch in muscle fibres. Using cutting-edge ultrasound imaging technology, human muscle strain in different regions of muscle will be examine ....The role of muscle and tendon mechanics in human muscle damage. This project aims to examine what sort of forceful stretch is required to cause exercise induced muscle damage (EIMD) in humans and how muscles adapt to limit future damage. Specifically, the project aims to examine how the elastic properties of tendons might reduce muscle damage by buffering stretch in muscle fibres. Using cutting-edge ultrasound imaging technology, human muscle strain in different regions of muscle will be examined to quantify the temporal relationship between muscle power absorption and EIMD. The importance of muscle and tendon mechanical properties in buffering the muscle from potential damage will be gauged. This could be a critical mechanism for preventing EIMD in exercising humans.Read moreRead less