Centre For Clinical Research Excellence In Anxiety And Neuroscience
Funder
National Health and Medical Research Council
Funding Amount
$2,007,200.00
Summary
This Centre will bring together Australia's leading anxiety and neuroscience researchers to develop, evaluate, and disseminate better treatments of anxiety. Epidemiological studies indicate that anxiety disorders are common, with lifetime prevalence estimated to be as high as 15% (1). These disorders share the features of excessive physiological arousal in response to feared stimuli, and this leads to pervasive avoidance that has a debilitating impact on people's lives. In addition, anxiety is o ....This Centre will bring together Australia's leading anxiety and neuroscience researchers to develop, evaluate, and disseminate better treatments of anxiety. Epidemiological studies indicate that anxiety disorders are common, with lifetime prevalence estimated to be as high as 15% (1). These disorders share the features of excessive physiological arousal in response to feared stimuli, and this leads to pervasive avoidance that has a debilitating impact on people's lives. In addition, anxiety is often present as a co-morbid feature of other major disorders, such as schizophrenia, substance use, and depression. Anxiety is one of the world's major health burdens; it costs $44 billion per year in the United States. Health agencies around the world are now putting unprecedented resources into understanding the neural bases of anxiety and its reduction. Building on recent advances in the neuroscience of anxiety, the Centre will expand the capacity for neurotransmitter modulation during therapy to reduce anxiety disorders. By extensive training programs with community clinicians, the Centre will conduct large-scale community trials to assess effectiveness of new approaches. The Centre will foster a new generation of neuroscience researchers and clinicians who are skilled in translating basic science findings into clinical practice.Read moreRead less
Prevention Of Childhood Anxiety: A Parent-focused Approach, Targeting The School Transition
Funder
National Health and Medical Research Council
Funding Amount
$60,220.00
Summary
The prevention of mental health problems in young people warrants research. Anxiety is a common problem amongst children, resulting in academic and relationship difficulties across the lifespan. The project investigates the effectiveness of an anxiety prevention strategy designed to optimise school adjustment in anxious and withdrawn preschool aged children making the transition to formal schooling. The intervention is parent-focused. Parents will be taught anxiety management strategies. They wi ....The prevention of mental health problems in young people warrants research. Anxiety is a common problem amongst children, resulting in academic and relationship difficulties across the lifespan. The project investigates the effectiveness of an anxiety prevention strategy designed to optimise school adjustment in anxious and withdrawn preschool aged children making the transition to formal schooling. The intervention is parent-focused. Parents will be taught anxiety management strategies. They will also be taught to decrease the use of overprotective or threat communicative responses, to model and reinforce non-anxious behaviour, and to coach children in active problem solving. The prevention of childhood anxiety will have important cost savings in the long term, relating to reduction in the costs associated with school adjustment difficulties and mental health treatments for children, as well as reductions in distress amongst individuals and their families. If the present program proves successful with children at risk of anxiety, it may have the potential to be offered within the education system as a universal transitional program.Read moreRead less
Enhanced Treatment For Social Phobia Through The Incorporation Of Attentional Re-training.
Funder
National Health and Medical Research Council
Funding Amount
$465,162.00
Summary
Social phobia is a serious difficulty that can cause tremendous interference in an individual's life. Social phobia can interfere with an individual's social and romantic life, work and study aspirations, and even increase medical and other psychological problems. Psychological programs to help individuals manage their anxiety have been developed and shown to lead to relatively strong positive outcomes. Recent theoretical understanding has suggested that one maintaining factor in social phobia m ....Social phobia is a serious difficulty that can cause tremendous interference in an individual's life. Social phobia can interfere with an individual's social and romantic life, work and study aspirations, and even increase medical and other psychological problems. Psychological programs to help individuals manage their anxiety have been developed and shown to lead to relatively strong positive outcomes. Recent theoretical understanding has suggested that one maintaining factor in social phobia may be these people's tendency to focus onto negative information. In some exciting developments, several researchers have shown that simply training people with social phobia to focus their attention away from negative information, with no other treatment components, can produce a marked change in their fears. Therefore it makes sense that incorporating these methods into current standard treatment packages, may increase their effectiveness. The current study aims to compare the current best practice treatment package for social phobia with a combination of this package plus the recent attention re-training methods. It is expected that incorporating attention re-training into standard treatment with significantly improve its effects.Read moreRead less
A Brain-Based Measure Of Anxiety Sensitivity: Validation Of A Novel Intermediate Phenotype With Psychophysiologically-Informed Neuroimaging
Funder
National Health and Medical Research Council
Funding Amount
$271,930.00
Summary
Excessive anxiety is disabling, such that people who suffer from a clinical anxiety disorder are often crippled by overwhelming emotional and physical symptoms. We will use sophisticated brain imaging technology to understand how certain brain areas produce feelings of anxiety, including a common fear of arousal related bodily sensations. This work is expected to enhance our basic understanding of the brain basis of anxiety symptoms and may inform new treatment options with biological rationale.
This project maps and manipulates the brainstem mechanisms causing expression of fear. It does so using brain cell type and brain circuit specific mechanisms.
The Prevention Of Anxiety And Related Disorders: Long Term Follow-up Of Temperamentally At-risk Preschoolers.
Funder
National Health and Medical Research Council
Funding Amount
$391,476.00
Summary
Anxiety and related disorders such as depression provide a tremendous cost to the individual sufferer and to Australian society. While previous research has focussed on treatment of these conditions, little work has addressed the possibility of preventing these disorders before they interfere with an individual's life. There is growing evidence that children who are shy, withdrawn and inhibited at a very young age are more likely than other children to develop anxiety disorders in later childhoo ....Anxiety and related disorders such as depression provide a tremendous cost to the individual sufferer and to Australian society. While previous research has focussed on treatment of these conditions, little work has addressed the possibility of preventing these disorders before they interfere with an individual's life. There is growing evidence that children who are shy, withdrawn and inhibited at a very young age are more likely than other children to develop anxiety disorders in later childhood and a variety of related disorders in adulthood. In a previous NHMRC-funded grant, we have developed a brief parent education program to modify this personality style in young children. Early results are very promising and it appears that we have been able to help these withdrawn children to become more outgoing. This next proposal aims to follow these children over the coming years to see whether they are also less likely to develop mental health problems than children whose parents have not received the educational program are. We will be observing the children in a laboratory setting and at school at three, yearly intervals. At each point, we will compare withdrawn children whose parents have gone through the education program with those who haven't.Read moreRead less
Enhancing Treatment Effectiveness In Acute Stress Disorder
Funder
National Health and Medical Research Council
Funding Amount
$235,330.00
Summary
Posttraumatic stress disorder (PTSD) is the most common psychiatric condition to develop after trauma. Early intervention of PTSD following a trauma is indicated because chronic PTSD can be resistant to treatment. Early intervention is possible because acute stress disorder immediately after a trauma identifies those people who will develop chronic PTSD. Although cognitive behaviour therapy of acute stress disorder can effectively prevent PTSD in many cases, many people do not benefit from this ....Posttraumatic stress disorder (PTSD) is the most common psychiatric condition to develop after trauma. Early intervention of PTSD following a trauma is indicated because chronic PTSD can be resistant to treatment. Early intervention is possible because acute stress disorder immediately after a trauma identifies those people who will develop chronic PTSD. Although cognitive behaviour therapy of acute stress disorder can effectively prevent PTSD in many cases, many people do not benefit from this treatment because this treatment involves exposure to distressing memories and emotions, and this contributes to many people dropping out of treatment. This project aims to extend the utility of early intervention following trauma by assessing approaches that can be used by most trauma survivors. The project compares early intervention with either exposure, cognitive therapy, combined exposure and cognitive therapy, or supportive counseling. All therapy will be conducted in the initial four weeks and will comprise 6 sessions. Assessments will be conducted posttreatment, six-months follow-up, and one-year follow-up. The outcomes of this project will have significant public health benefits because they will lead to increased treatment effectiveness for acutely traumatized people, and will markedly reduce the incidence of PTSD in the community.Read moreRead less
The Effectiveness Of An Early Intervention And Prevention Strategy For Anxiety And Depressive Disorders.
Funder
National Health and Medical Research Council
Funding Amount
$119,924.00
Summary
Adult anxiety and depressive disorders are common, cause significant distress to sufferers and cost to the community, and generally begin in childhood. Prior research has shown that children who exhibit higher than average levels of anxiety in their late childhood are at risk for developing anxiety and depressive disorders as they grow older. However if at risk children can learn skills to better manage their anxiety, the chance that they will continue to experience significant anxiety problems ....Adult anxiety and depressive disorders are common, cause significant distress to sufferers and cost to the community, and generally begin in childhood. Prior research has shown that children who exhibit higher than average levels of anxiety in their late childhood are at risk for developing anxiety and depressive disorders as they grow older. However if at risk children can learn skills to better manage their anxiety, the chance that they will continue to experience significant anxiety problems is greatly reduced. For example, school-based skills-building programs run by specialist mental health professionals have been shown to reduce the rate of existing anxiety disorder and prevent the onset of new anxiety disorders across middle to late childhood and early adolescence. The proposed study will aim to show that a school-based program, run by school counsellors, can prevent the development of anxiety and depressive disorders in late adolescence. In other words, the aim is to demonstrate whether the benefit of the program can be achieved across the wider school-aged population when conducted wholly within the education sector. This outcome is significant, not only in its potential to reduce distress to a large number of adolescents and their families, but in reducing costs to the community in terms of reduced disability and reduced need for health care and specialist mental health treatment.Read moreRead less