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Anthocyanin Inhibitors to the Influenza Virus. The increasing resistance of circulating influenza strains to current anti-viral inhibitors has prompted an investigation to screen, design, synthesize and evaluate a new class of natural product based inhibitors to the virus employing novel and innovative mass spectrometry, computational and structural approaches. Preliminary studies reveal they offer benefits in terms of a different mode of binding to influenza neuraminidase, remote from many know ....Anthocyanin Inhibitors to the Influenza Virus. The increasing resistance of circulating influenza strains to current anti-viral inhibitors has prompted an investigation to screen, design, synthesize and evaluate a new class of natural product based inhibitors to the virus employing novel and innovative mass spectrometry, computational and structural approaches. Preliminary studies reveal they offer benefits in terms of a different mode of binding to influenza neuraminidase, remote from many known resistance mutations, and may have specific practicality against N1 neuraminidase in H1N1 and H5N1 viruses responsible for all pandemics of the 20th and 21st centuries. The research will enable the potential of these inhibitors to be fully assessed at the molecular level for the first time.Read moreRead less
Probing antimicrobial drug resistance by multimodal molecular analysis. This project aims to investigate drug resistance in microbial agents. With the emergence of "super bugs" there is a need to understand the biochemistry of antimicrobial resistance. Combining vibrational spectroscopic approaches and metabolomic techniques, the project will investigate cell populations, single cells and subcellular structures in search of biomarkers for drug resistance. The discovery of such biomarkers could l ....Probing antimicrobial drug resistance by multimodal molecular analysis. This project aims to investigate drug resistance in microbial agents. With the emergence of "super bugs" there is a need to understand the biochemistry of antimicrobial resistance. Combining vibrational spectroscopic approaches and metabolomic techniques, the project will investigate cell populations, single cells and subcellular structures in search of biomarkers for drug resistance. The discovery of such biomarkers could lead to improved disease management and eradication programs through identification and treatment of drug resistant pathogens in individuals that have the potential to re-infect the community.Read moreRead less
Mechanisms of human immunodeficiency virus entry into cells. This project will develop an understanding of how human immunodeficiency virus (HIV) evolves in people to become better able to infect, and hence destroy, cells of the immune system. It is expected that new knowledge into how HIV alters the way it interacts with these cells will reveal insights for the design of vaccines, drugs and new diagnostic tests.