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Molecular Pathways Mediating Quiescence And Resistance In Leukaemia Stem Cells In Acute Myeloid Leukaemia.
Funder
National Health and Medical Research Council
Funding Amount
$100,381.00
Summary
Acute myeloid leukaemia (AML) is a devastating cancer of the blood and bone marrow which is rapidly fatal unless effectively treated with chemotherapy. AML is caused by genetic events that alter normal blood stem cells to give them a growth and survival advantage and also may confer resistance to chemotherapy in some cases. We will evaluate and target the mechanism of this resistance in laboratory models. This information can then be used to design new treatments to improve outcomes in AML.
Identification And Characterisation Of Novel Copper Homeostasis Genes And Proteins
Funder
National Health and Medical Research Council
Funding Amount
$70,307.00
Summary
Copper is an essential nutrient that is also toxic when in excess. Specific mechanisms exist to regulate copper levels and these are conserved across many species. Disrupted copper regulation contributes to many diseases including: cardiovascular disease, osteoporosis and Alzheimer’s. I aim to identify and characterise novel copper regulatory proteins using the model organism Drosophila (vinegar fly) together with human cultured cells as a foundation for work to prevent or treat these diseases.
The Role Of Presenilin In Metal Homeostasis And Alzheimers Disease
Funder
National Health and Medical Research Council
Funding Amount
$86,335.00
Summary
Presenilin, a protein involved in Alzheimer’s disease (AD), may regulate copper and zinc levels. Copper and zinc are essential nutrients however a deficiency or excess can cause disease. Promising metal-altering AD drugs, are in various stages of clinical trial. I aim to characterize the interaction of Presenilin and metals using both mouse and cultured human cell models that are deficient in Presenilin. Understanding this interaction should lead to better drug design and treatment of AD.
The Effect Of Aging And Mitochondria Dysfunction On Optic Nerve Response To Oxidative Stress In Glaucoma
Funder
National Health and Medical Research Council
Funding Amount
$100,381.00
Summary
Glaucoma is a disease of the nerve cells in the retina and optic nerve of the eye, it is the second most common cause of blindness worldwide. The risk of developing glaucoma increases exponentially with age but the mechanisms that predispose older individuals to glaucoma are not known. This study examines whether age-related changes in mitochondria, a characteristic finding in aging, results in increase susceptibility to glaucoma development.