Data-led bioengineering to uncover hidden chemical wealth in bacteria. The soil bacteria Nocardia are an untapped source of industrially prized chemical compounds called natural products. This project aims to develop innovative bioprospecting genomics technologies built from the disciplines of microbiology, biochemistry and computational statistics to discover hundreds of new natural products in Nocardia. This project will unlock the diversity of potent new enzymes and molecules with high econom ....Data-led bioengineering to uncover hidden chemical wealth in bacteria. The soil bacteria Nocardia are an untapped source of industrially prized chemical compounds called natural products. This project aims to develop innovative bioprospecting genomics technologies built from the disciplines of microbiology, biochemistry and computational statistics to discover hundreds of new natural products in Nocardia. This project will unlock the diversity of potent new enzymes and molecules with high economic value that could include insecticides to protect crops, bioactives to fight diseases, or new enzymes for food and biofuel production. This research unlocks enormous hidden chemical potential in soil bacteria, to build sustainable national economic growth through innovative, high-value industrial chemical development.Read moreRead less
Mid-Career Industry Fellowships - Grant ID: IM230100534
Funder
Australian Research Council
Funding Amount
$874,096.00
Summary
NOVEL MASS-SCALE BIOSYNTHESIS: TAILORING CHEMICAL LOGIC & BIOSYNTHESIS. No new antibiotics against Gram-negative ‘superbugs’ are expected to be available in the near future. We have exhausted the chemical space from the natural product pool and lack a fundamental understanding of antibiotics in nature, this is a major hurdle for antibiotic design targeting bacterial resistance. This proposal aims to engineer unique chemo-enzymatic platforms for the synthesis of new lipopeptide scaffolds which wi ....NOVEL MASS-SCALE BIOSYNTHESIS: TAILORING CHEMICAL LOGIC & BIOSYNTHESIS. No new antibiotics against Gram-negative ‘superbugs’ are expected to be available in the near future. We have exhausted the chemical space from the natural product pool and lack a fundamental understanding of antibiotics in nature, this is a major hurdle for antibiotic design targeting bacterial resistance. This proposal aims to engineer unique chemo-enzymatic platforms for the synthesis of new lipopeptide scaffolds which will significantly expand the chemical space available for novel antibiotic discovery. The development of these unique platforms will greatly expand our inventory of natural product antibiotics and will represent a major technological break-through for Australia's biotechnology and pharmaceutical manufacturing sectors.Read moreRead less
ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems. ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems. The ARC Centre for the Mathematical Analysis of Cellular Systems aims to deliver the mathematics required to compute life. The Centre will deliver innovation in computational and mathematical biology and establish in silico biology alongside in vivo and in vitro biology. These models will allow us to understand the complexity of life at the cellu ....ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems. ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems. The ARC Centre for the Mathematical Analysis of Cellular Systems aims to deliver the mathematics required to compute life. The Centre will deliver innovation in computational and mathematical biology and establish in silico biology alongside in vivo and in vitro biology. These models will allow us to understand the complexity of life at the cellular level and enable new ways of combining diverse and heterogenous data. This will allow us to understand the mechanisms underlying cellular behaviour, and to apply rational design engineering methods in order to control the dynamics of biological systems. Read moreRead less
Surface ligation of nanomaterials for biomedical applications . The project aims to explore the synergistic effects co-ligands for target recognition and biofouling protection in nanoparticle surface patterns to enable practical atomic scale precision engineering of efficient and biofouling resistant nanosensors. The project will fundamentally characterise interfacial interactions and dynamics of ligated nano-surfaces and biomolecules via advanced computer modelling. Outcomes should include pra ....Surface ligation of nanomaterials for biomedical applications . The project aims to explore the synergistic effects co-ligands for target recognition and biofouling protection in nanoparticle surface patterns to enable practical atomic scale precision engineering of efficient and biofouling resistant nanosensors. The project will fundamentally characterise interfacial interactions and dynamics of ligated nano-surfaces and biomolecules via advanced computer modelling. Outcomes should include practical molecular design guidelines for functional ligands and predicted optimal patterns for combining functional and antifouling ligands on gold nanomaterials for biosensing technologies. The advanced predictive modelling capabilities will facilitate future practical engineering of efficient biomedical devices.Read moreRead less