A National Centre For Antimicrobial Stewardship: Using A One Health Approach
Funder
National Health and Medical Research Council
Funding Amount
$2,601,801.00
Summary
The emergence of antimicrobial resistance is a serious worldwide problem. The National Centre for Antimicrobial Stewardship will use a One Health approach to address antibiotic use in both humans and animals. We will focus on hospitals, aged care, and general practice. In animal health, we will investigate links between antibiotic use in animal production and resistant bacteria, and evaluate usage in companion animals. The aim is to promote appropriate antibiotic use in animal and human health.
Towards Reducing Resistance And Haematological Toxicity Of Linezolid
Funder
National Health and Medical Research Council
Funding Amount
$135,825.00
Summary
Multi-drug resistance in bacteria is increasing at an alarming rate. We have diminishing therapeutic options, and there are few antibiotics in the drug development pipeline that offer much hope. It is therefore important that we look towards ways of further optimising the use of antibiotics that we currently have available. An important last line of defense drug, linezolid, has been available in Australia for less than 2 years and already resistance is occuring. In addition, with broader use of ....Multi-drug resistance in bacteria is increasing at an alarming rate. We have diminishing therapeutic options, and there are few antibiotics in the drug development pipeline that offer much hope. It is therefore important that we look towards ways of further optimising the use of antibiotics that we currently have available. An important last line of defense drug, linezolid, has been available in Australia for less than 2 years and already resistance is occuring. In addition, with broader use of this drug outside clinical trials, there has been an increasing concern over its toxicity to important blood cells. We seek to better understand the determinants of linezolid resistance and toxicity, so that novel dosing strategies may be developed to optimise its use (reduce toxicity and enhance efficacy) thereby extending the usefulness of this last line of defense antibiotic.Read moreRead less
Integrative Systems Pharmacology, Neutron Reflectometry And Molecular Dynamics Approaches To Unravelling The Interactions Between Polymyxins And Bacterial Membranes
Funder
National Health and Medical Research Council
Funding Amount
$968,005.00
Summary
Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii are among the 6 top-priority dangerous ‘superbugs’ causing life-threatening infections worldwide. This study will employ a multi-disciplinary approach to decipher the complex interactions of polymyxins with the membranes of these three ‘superbugs’ and to discover novel antibiotics with superior efficacy. This innovative project targets the urgent unmet global medical crisis due to antibiotic resistance.
Towards Optimising Dosing Of The 'old' Antibiotic Colistin Methanesulphonate: Enhancing Efficacy And Reducing Resistance
Funder
National Health and Medical Research Council
Funding Amount
$266,500.00
Summary
The global problem of multidrug-resistant bacteria is a major clinical challenge. In cystic fibrosis (CF) patients, the bacteria pseudomonas shows significantly high resistance to the commonly used antibiotics and is a major cause of death. As a consequence, interest in an old antibiotic, colistin, has been rekindled after 40 years on the shelf. The safety of intravenous colistin has been demonstrated in several clinical trials. However, based on our preliminary studies in CF patients, the curre ....The global problem of multidrug-resistant bacteria is a major clinical challenge. In cystic fibrosis (CF) patients, the bacteria pseudomonas shows significantly high resistance to the commonly used antibiotics and is a major cause of death. As a consequence, interest in an old antibiotic, colistin, has been rekindled after 40 years on the shelf. The safety of intravenous colistin has been demonstrated in several clinical trials. However, based on our preliminary studies in CF patients, the current dosage regimen where colistin is given three times a day does not achieve high enough concentrations to kill the bacteria. The studies proposed in this project will address the safety, effectivenss and impact on development of resistance of larger doses of intravenous colistin given once or twice daily. We propose that such dosing strategies will yield more effective usage of this promising 'old' antibiotic.Read moreRead less
Targeting The Unmet Global Medical Need Caused By Gram-negative 'superbugs': From Antibiotic Discovery To Novel Therapeutic Strategies
Funder
National Health and Medical Research Council
Funding Amount
$697,209.00
Summary
Bacterial ‘superbugs’ present a significant global medical challenge. ‘Old’ polymyxins are the only antibiotics against Gram-negative ‘superbugs’ but with limited pharmacological information available. In the next 5 years, as a pharmacologist I will continue re-developing polymyxins and discovering novel antibiotics against these problematic bacteria. My research targets the “Bad Bugs, No Drugs” disaster highlighted by the Infectious Diseases Society of America and the World Health Organization.
The Development Of Novel Antibacterials Targeting Clostridium Difficile Infections
Funder
National Health and Medical Research Council
Funding Amount
$750,546.00
Summary
Clostridium difficile is a bacterium associated with infections in the gut which may result in mild to severe diarrhoea and inflammation of the colon. These infections are an increasing problem for hospitalised patients in the US, the EU and Australia. We have been very successful in the past at developing new drugs to treat external infections caused by resistant strains of bacteria, for example, golden Staph. We now aim to develop our drugs to treat C. difficile infections in the gut.
Redefining Antibiotic Dosing To Reduce Bacterial Resistance
Funder
National Health and Medical Research Council
Funding Amount
$474,513.00
Summary
>3000 Australians die every year from severe infections (nearly 3-fold higher in number than our annual road toll). These treatment failures are due to sub-optimal antibiotic dosing from a poor understanding of why concentrations are different in these patients. I will use my laboratory to define what antibiotic concentrations we need to achieve and perform clinical studies with my collaborative network to demonstrate that we can redefine antibiotic dosing to reduce the emergence of superbugs ....>3000 Australians die every year from severe infections (nearly 3-fold higher in number than our annual road toll). These treatment failures are due to sub-optimal antibiotic dosing from a poor understanding of why concentrations are different in these patients. I will use my laboratory to define what antibiotic concentrations we need to achieve and perform clinical studies with my collaborative network to demonstrate that we can redefine antibiotic dosing to reduce the emergence of superbugs.Read moreRead less
Antimicrobial Stewardship – Establishing An Effective Model For Australian Private Hospitals
Funder
National Health and Medical Research Council
Funding Amount
$55,807.00
Summary
Inappropriate and overuse of antibiotics in hospitals has accelerated world-wide antimicrobial resistance. Strategies to improve antibiotic prescribing have been effective in slowing down antibiotic resistance, however there has been little uptake of these strategies in Australian private hospitals. Needs, resources, and current barriers for these strategies will be investigated in the private hospital setting and results will be used to construct a program model that can be adopted by private h ....Inappropriate and overuse of antibiotics in hospitals has accelerated world-wide antimicrobial resistance. Strategies to improve antibiotic prescribing have been effective in slowing down antibiotic resistance, however there has been little uptake of these strategies in Australian private hospitals. Needs, resources, and current barriers for these strategies will be investigated in the private hospital setting and results will be used to construct a program model that can be adopted by private hospitals in AustraliaRead moreRead less
This program directly addresses the major threat of antimicrobial resistance , bringing together the power of modern genomics and the promise of novel positive therapies to eradicate AMR organisms and AMR genes from individuals at risk from severe infection.