How Do Cross-reactive Memory B Cells Affect Influenza Vaccine Titers?
Funder
National Health and Medical Research Council
Funding Amount
$798,049.00
Summary
Influenza vaccines are updated frequently to protect against the highly variable influenza virus. Despite careful selection of vaccine viruses, most influenza vaccines provide only modest protection and protection is poor some years. In turn, the response to vaccination varies between individuals. This probably reflects complex and variable histories of influenza infection and vaccination. The project investigates how past influenza exposure influences vaccine responses and effectiveness.
Wrong Parasite, Wrong Host? How Plasmodium Falciparum Erythrocyte Membrane Protein 1 Expression And The Host’s Innate Immune Response Combine To Influence The Inflammatory Response To Malaria In Vitro And In Vivo. Implications For Severe Malaria
Funder
National Health and Medical Research Council
Funding Amount
$707,821.00
Summary
One factor that determines whether some children die of malaria is the type of protein that the parasite expresses on the red blood cell, to help it stick in blood vessels. Our new data suggests that some proteins stimulate excessive host immune response, possibly leading to severe malaria. People's immne response to malaria varies too, and we will discover whether severe malaria occurs when a dangerous parasite strain infects a susceptible host causing an excessive immune response, harming the ....One factor that determines whether some children die of malaria is the type of protein that the parasite expresses on the red blood cell, to help it stick in blood vessels. Our new data suggests that some proteins stimulate excessive host immune response, possibly leading to severe malaria. People's immne response to malaria varies too, and we will discover whether severe malaria occurs when a dangerous parasite strain infects a susceptible host causing an excessive immune response, harming the child.Read moreRead less