Development And Validation Of A Latent Tuberculosis Diagnostic
Funder
National Health and Medical Research Council
Funding Amount
$534,865.00
Summary
Globally, tuberculosis is a leading cause of death with 9.6 million new diagnoses in 2014. The diagnosis of latent TB infection is important, but is difficult to make because current assays are suboptimal. We have developed a very simple assay which detects responses to TB antigens by co-expression of two surface markers expressed by CD4+ T cells. We propose to develop this into a highly standardised kit for the diagnosis of TB with our commercial partner Cytognos.
Variation and Perceptual Ecologies in Computer Games and Simulations: Towards a Generic Model of Variable 3D Environments. The non repeatability is a key element in providing a challenging and interesting experience in computer games and simulations. However, too much variation could lead to a rejection of the environment and reluctance to accept the premise as a base for game play or training. Examples of applications that could utilise this research include; (a) Computer Games - always playing ....Variation and Perceptual Ecologies in Computer Games and Simulations: Towards a Generic Model of Variable 3D Environments. The non repeatability is a key element in providing a challenging and interesting experience in computer games and simulations. However, too much variation could lead to a rejection of the environment and reluctance to accept the premise as a base for game play or training. Examples of applications that could utilise this research include; (a) Computer Games - always playing in an unknown environment, (b) Vocational Training - a Forest Fire Fighting simulation that allows for different terrain configurations, undergrowth volatility, fire source, etc., and (c) Military Simulations - Anti-terrorist simulations where the level of variability will manifest itself both in the physical environment and in the nature of the combatants. Read moreRead less
Mapping ear morphology to individualised three dimensional audio. The project aims to develop a practical method to derive a listener's individualised Head Related Transfer Functions from two dimensional images of the head and ears. These are essential for generating high-fidelity three dimensional audio. The project will perceptually evaluate and test the proposed system when applied to teleconferencing, surveillance, and navigational guidance.
Individualisation for 3D Audio. The project aim is to allow the general listener to enjoy high-fidelity 3-D sound over headphones. Such 3-D audio is of paramount importance when inter-personal communication requires situational awareness, (eg search and rescue, fire-fighting, and air traffic control). To achieve this, the project aims to address one of the toughest problems in audio signal processing: deriving high-fidelity 3-D audio headphone filters from photos and/or 3D scans of ears. The pro ....Individualisation for 3D Audio. The project aim is to allow the general listener to enjoy high-fidelity 3-D sound over headphones. Such 3-D audio is of paramount importance when inter-personal communication requires situational awareness, (eg search and rescue, fire-fighting, and air traffic control). To achieve this, the project aims to address one of the toughest problems in audio signal processing: deriving high-fidelity 3-D audio headphone filters from photos and/or 3D scans of ears. The project plans to address fundamental research questions in statistical shape and data analysis and to perceptually evaluate the 3-D audio methods developed.Read moreRead less
Drug-induced Immune Thrombocytopenia: Understanding The Disease Mechanisms Is The Key To Better Treatment
Funder
National Health and Medical Research Council
Funding Amount
$509,550.00
Summary
Many very commonly used medications cause an allergic reaction in a small number of patients that receive them. The allergic reaction results in platelets being destroyed and puts the patients at risk of bleeding. The patient recovers slowly if the drug is stopped but there is no other treatment and no way to reverse the effect quickly if the patient starts to bleed. This project will try to understand the mechanism of the condition and test a potential treatment.
Dynamic Controllability Analysis for Plantwide Process Design and Control. World-wide chemical plants represent many billions of dollars of investment. Improvements to the process designs in terms of controllability would have the potential to provide large economic benefits, as it implies improved productivity, reduced operating costs and product variability. This proposed research will be a step towards integration of process design and control, which has been widely recognized as the key to t ....Dynamic Controllability Analysis for Plantwide Process Design and Control. World-wide chemical plants represent many billions of dollars of investment. Improvements to the process designs in terms of controllability would have the potential to provide large economic benefits, as it implies improved productivity, reduced operating costs and product variability. This proposed research will be a step towards integration of process design and control, which has been widely recognized as the key to this improvement. The outcomes from this project may be readily implemented in process design practice, and therefore have a direct impact to the Australian and world-wide process industries, helping to build a more efficient and environmental conscious Australian process industries.Read moreRead less
Bayesian Inference for Multivariate Hierarchical Regression Models. This project will develop Bayesian methodology for analysing multivariate regression models. The distribution of each measurement can be discrete or continuous, with the dependence between measurements obtained through the correlation matrix of a Gaussian copula. Model parsimony is obtained by identifying zero elements in the correlation matrix or its inverse and by variable selection on the regression parameters. The results wi ....Bayesian Inference for Multivariate Hierarchical Regression Models. This project will develop Bayesian methodology for analysing multivariate regression models. The distribution of each measurement can be discrete or continuous, with the dependence between measurements obtained through the correlation matrix of a Gaussian copula. Model parsimony is obtained by identifying zero elements in the correlation matrix or its inverse and by variable selection on the regression parameters. The results will be applied to solve problems in finance, health management and marketing. In all these fields multiple observations are often taken per individual or time period and the models need to incorporate measures of dependence and uncertainty.Read moreRead less
Improving Patient Safety In Radiation Therapy With The Watchdog Real-time Treatment Delivery Verification System
Funder
National Health and Medical Research Council
Funding Amount
$593,742.00
Summary
Radiation therapy is a highly effective cancer treatment with extremely high doses delivered using very complex treatment machines. Unfortunately errors have occurred resulting in cases of patient death and mistreatment. We have developed a novel method to assess the treatment delivery in real-time to prevent errors. The method uses imaging devices that are already present on the treatment machine meaning that this method could have a major impact on patient safety in modern radiation therapy.
Reducing The Greatest Uncertainty In Radiotherapy.
Funder
National Health and Medical Research Council
Funding Amount
$594,197.00
Summary
The weakest link in radiotherapy is defining treatment volumes (contouring). Lack of accuracy and consistency in clinical trial contouring has been shown to result in reduced patient outcomes. Manual review of contouring is resource intensive, expensive and for advanced treatments unachievable in a timely fashion. We will assess an automated approach to contouring assessment using 4 clinical trial datasets, changing practice for future studies and enabling consistent assessment in the clinic.
Nano-Rheology and Nano-Tribology: Atomistic Simulation of Boundary Lubrication. Manufacturing in atomic level is going to transform the efficiency level in many important applications. As molecular biology transformed medical and biological sciences,so molecular level material design and the techniques involved are going to significantly affect the engineering applications and manufacturing in coming decades. We have no doubt the benefits will flow from the project to many disciplines that are c ....Nano-Rheology and Nano-Tribology: Atomistic Simulation of Boundary Lubrication. Manufacturing in atomic level is going to transform the efficiency level in many important applications. As molecular biology transformed medical and biological sciences,so molecular level material design and the techniques involved are going to significantly affect the engineering applications and manufacturing in coming decades. We have no doubt the benefits will flow from the project to many disciplines that are critical in manufacturing and commercialisation of nano-devices. The results will position Australia in the forefront of one of the most important leading edge technologies in the world. This not only will improve Australia's research profile in the world but also will enable it to capitalize on any future commercial outcomesRead moreRead less