The Impact Of Therapy On T-cell Recognition Of Mutated Tumour Neo-antigens
Funder
National Health and Medical Research Council
Funding Amount
$1,126,685.00
Summary
Cancer is caused by mutations which should be 'seen' and destroyed by the patients immune cells, similar to how immune cells protect us against viruses. But they don't. This grant will study how current cancer treatments help the immune cells 'see' these mutations. We will undertake these studies in the important cancers lung cancer and mesothelioma.
Reducing environmental footprint by improving phosphorous use efficiency. While modern agriculture relies heavily on the use of phosphorous fertilizers, most of them are not used by plants and lost in runoff, resulting in a massive environmental damage through contamination of waterways (termed eutrophication). This project takes advantage of an untapped resource - a unique collection of Tibetan wild barley genotypes, to reveal key traits that confer superior phosphorus use efficiency in wild ba ....Reducing environmental footprint by improving phosphorous use efficiency. While modern agriculture relies heavily on the use of phosphorous fertilizers, most of them are not used by plants and lost in runoff, resulting in a massive environmental damage through contamination of waterways (termed eutrophication). This project takes advantage of an untapped resource - a unique collection of Tibetan wild barley genotypes, to reveal key traits that confer superior phosphorus use efficiency in wild barley and identify appropriate candidate genes and their position on chromosomes for further incorporating these traits into commercial barley cultivars. This will reduce the environmental footprint of modern agricultural practices on terrestrial and aquatic ecosystems without compromising food security.Read moreRead less
Brassica genome organisation and evolution: unlocking the potential of using genome-specific repetitive elements for crop improvement. Introgression of chromosome segments from related Brassica species provides an opportunity to develop locally adapted varieties with improved agronomic and quality traits. There is a need to understand Brassica genome organisation and how this information can be used for enhancing the efficiency of cultivar development. Dispersed and tandem repetitive DNA sequen ....Brassica genome organisation and evolution: unlocking the potential of using genome-specific repetitive elements for crop improvement. Introgression of chromosome segments from related Brassica species provides an opportunity to develop locally adapted varieties with improved agronomic and quality traits. There is a need to understand Brassica genome organisation and how this information can be used for enhancing the efficiency of cultivar development. Dispersed and tandem repetitive DNA sequences provide valuable information on the organisation and evolution of plant chromosomes. Methods for monitoring chromosome segment transfer across Brassica species will be developed based on detecting and quantifying genome-specific repetitive DNA sequences. Australian Brassica improvement programs could benefit from this research by adopting methods to detect chromosome segment transfer during interspecific hybridisation.Read moreRead less
Exploiting the Arabidopsis genome sequence as a molecular 'toolbox' for Brassica improvement. Australia's position as a major exporter of canola (Brassica napus) is under threat from genetic improvements in yield and quality being made by our international competitors. We will identify genes from Arabidopsis (the 'tool-box') that will be used to increase the speed of selection of new canola varieties with improved oleic acid content, disease resistance, and agronomic traits such as early flower ....Exploiting the Arabidopsis genome sequence as a molecular 'toolbox' for Brassica improvement. Australia's position as a major exporter of canola (Brassica napus) is under threat from genetic improvements in yield and quality being made by our international competitors. We will identify genes from Arabidopsis (the 'tool-box') that will be used to increase the speed of selection of new canola varieties with improved oleic acid content, disease resistance, and agronomic traits such as early flowering and cold tolerance. Genome similarity between Arabidopsis and canola will be exploited to map specific genes from Arabidopsis directly into canola. Based on this knowledge, we will develop gene-specific molecular markers for rapid selection of Australian-adapted canola varieties.Read moreRead less