A Novel Point Of Care (PoC) Device For Predicting And Monitoring Bleeding And Clotting (haemostasis)
Funder
National Health and Medical Research Council
Funding Amount
$608,979.00
Summary
Manipulating the bleeding/clotting system is a critical but expensive part of modern medicine, eg some people need blood thinners while others can bleed too much. Thrombin generation is the ideal overall test for the bleeding/clotting of blood, but current methods have major problems. We developed and patented a test that deals with most of the problems. This proposal will create an assay that is easy for doctors to perform without a specialised laboratory.
Platelet Glycoprotein Proteolysis: Novel Mechanisms And Risk Factors
Funder
National Health and Medical Research Council
Funding Amount
$441,473.00
Summary
Platelets are the richest source of amyloid precursor protein (APP) in the body. Platelet ADAM10 regulates both the expression and function of the major platelet collagen receptor GPVI, and protective APP processing. Coagulation protein Factor X has a role in activation of ADAM10. This activation is disrupted in blood that has been treated with direct oral anticoagulant (DOAC) rivaroxaban. This grant will investigate the implications for people taking rivaroxaban on regulation of APP and GPVI.
Kidney Function And The Effectiveness And Safety Of Direct Oral Anticoagulants In Atrial Fibrillation: The KODIAK-AF Study
Funder
National Health and Medical Research Council
Funding Amount
$451,730.00
Summary
The direct oral anticoagulants (DOACs) are a relatively new type of drug that are used to prevent the onset of stroke among patients with atrial fibrillation (AF). While these drugs have been demonstrated to be safe and effective among AF patients, in those AF patients with chronic kidney disease (CKD), there is uncertainty as to whether these drugs are similarly safe. This program of research will study the safety profile of DOACs in patients with AF and CKD.
Enabling Personalised Cohort Studies From Large Repositories Of Clinical Practice Data
Funder
National Health and Medical Research Council
Funding Amount
$520,968.00
Summary
We propose to leverage the information contained in large, routinely collected health datasets, by enabling personalised cohort studies on demand. Findings from these studies can be used to crowdsource prioritisation of clinical questions in need of further evidence. They can also provide an avenue to discuss and support treatment recommendations at the point-of-care.
Interactions Between Herbal Medicines And The Anticoagulant Warfarin
Funder
National Health and Medical Research Council
Funding Amount
$440,250.00
Summary
Complementary medicines are used widely in our community. Products are advertised as safe despite the fact that many have never been systematically tested for either efficacy or safety. Little is known about the potential for herbal medicines to interact with conventional medicines which may lead to potentially serious consequences. Clinical reports suggest that there is potential for an interaction between warfarin and herbal medicines. Interactions with warfarin in patients receiving the drug ....Complementary medicines are used widely in our community. Products are advertised as safe despite the fact that many have never been systematically tested for either efficacy or safety. Little is known about the potential for herbal medicines to interact with conventional medicines which may lead to potentially serious consequences. Clinical reports suggest that there is potential for an interaction between warfarin and herbal medicines. Interactions with warfarin in patients receiving the drug as part of their therapy can be life threatening. Identifying and avoiding significant drug interactions with warfarin can reduce patient problems caused by excessive bleeding, reduce length of hospital stay and decrease the need for frequent blood monitoring. The present study design will also provide a valuable insight into possible interactions with other medicines by understanding the mechanism of possible herb-drug interactions.Read moreRead less