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Germinal Centres, Rogue B Cells And The Genesis Of Immunological Diseases.
Funder
National Health and Medical Research Council
Funding Amount
$753,300.00
Summary
This study will determine how the immune system is normally prevented from producing autoantibodies that target the body's own cells and how this fails in autoimmune diseases such as lupus. Targeted studies of a newly discovered "rogue" white blood cell will also provide new clues on how autoimmune diseases arise. In addition, modeling of human immunological disease in mice via CRISPR/Cas9 mutagenesis will provide valuable new insights into their causes and potential treatments.
Dissecting Human B-cell Function: From Primary Immunodeficiencies To Chronic Inflammatory Disease
Funder
National Health and Medical Research Council
Funding Amount
$631,370.00
Summary
Despite knowing a lot about immunity in a mice, functional analysis of the human immune system has been a major challenge. I will study defects of immune cells in humans with gene mutations that cause an antibody deficiency. With new insights from these unique clinical samples, I will functionally dissect human immune responses, directly translate these to chronic inflammatory disease, and provide implications for future vaccine development and cancer treatment.
Immunological Diseases: Understanding Their Cause And Improving Their Treatment By Human Genome Sequencing
Funder
National Health and Medical Research Council
Funding Amount
$788,486.00
Summary
Prof Goodnow will develop a collaborative consortium of specialist physicians, laboratory researchers and bioinformaticians. This team will apply the new tools of large scale DNA sequencing to reveal the root cause of immune system diseases including: autoimmune diseases, congenital immune deficiency diseases, allergic disorders, and cancer. It aims to accelerate, simplify and unify the diagnosis of these diseases, and guide targeted, earlier and more effective treatment.
The major objective of this research is to advance the development of highly effective malaria vaccines through i) defining mechanisms and targets of human immunity to malaria to establish a rational basis for vaccine design; ii) advancing the development of lead candidates and promising new candidates and combinations; iii) advancing vaccine platforms that induce potent protective immune responses; iv) develop and validate urgently-needed immunological assays for vaccine development and testing
Understanding the immune response is proving extremely complex and promising results for disease treatments from animal models are often difficult to translate to new clinical therapies. My research is unearthing weaknesses in our current knowledge of the immune system and seeking to replace them with a foundation that can exploit new developments in computer modelling and systems biology. In this way I aim to rationally manipulate the immune response.
Control Of Pathogenic Antibody Responses In Humans
Funder
National Health and Medical Research Council
Funding Amount
$763,845.00
Summary
Deficient or inappropriate antibody responses are at the core of many autoimmune diseases, allergies, food intolerances, and often explain the failure of vaccination strategies. Specialised follicular T cells control the quality of antibodies produced by B cells. This fellowship will combine basic studies investigating B cell helper or regulatory follicular T cells in humans with genetic studies identifying the causes of autoantibody-driven diseases. The results will uncover targeted therapies.
I am an immunologist focusing on understanding how can we combat chronic infections while preventing autoimmunity. This proposal aims to investigate how a poorly understood subset of lymphocytes called Tfh cells are regulated to promote the formation of protective antibodies, and prevent development of harmful antibodies that go on to cause or exacerbate diseases such as lupus, rheumatoid arthritis and type 1 diabetes. Our discoveries will illuminate novel drug targets for these diseases and hel ....I am an immunologist focusing on understanding how can we combat chronic infections while preventing autoimmunity. This proposal aims to investigate how a poorly understood subset of lymphocytes called Tfh cells are regulated to promote the formation of protective antibodies, and prevent development of harmful antibodies that go on to cause or exacerbate diseases such as lupus, rheumatoid arthritis and type 1 diabetes. Our discoveries will illuminate novel drug targets for these diseases and help generate more potent vaccines.Read moreRead less
Wounds are not just the simple cuts and abrasions that can be covered with a band-aid and healed within days with no major consequence. They are a largely unrecognised spiralling epidemic that is affecting millions of people world-wide. This project aims to develop new approaches to heal wounds with research that is innovative, cross-disciplinary and has the ability to transform current approaches for wound management.
Improving Health Outcomes In Drug Overdose And Envenoming: Risk Assessment And Interventional Studies
Funder
National Health and Medical Research Council
Funding Amount
$772,209.00
Summary
The research aims to improve our understanding of the mechanisms and treatments for poisoning and envenoming. Observational studies measuring toxin levels will be done to investigate the effects of drug overdose and terrestrial and marine envenoming. Clinical trials will be done to investigate the benefit and safety of antivenom in snake/spider envenoming, antidotes and other treatments for drug overdose, including decontamination such as activated charcoal. Clinical studies will involve multipl ....The research aims to improve our understanding of the mechanisms and treatments for poisoning and envenoming. Observational studies measuring toxin levels will be done to investigate the effects of drug overdose and terrestrial and marine envenoming. Clinical trials will be done to investigate the benefit and safety of antivenom in snake/spider envenoming, antidotes and other treatments for drug overdose, including decontamination such as activated charcoal. Clinical studies will involve multiple hospitals across Australia.Read moreRead less
I am a hematologist with expertise in the science of immunology and clinical experience in bone marrow transplantation and the treatment of hematological malignancies. My vision is to study the biology of dendritic cells, which are the specialized white cells that initiate the immune response, and then, to apply this knowledge to the design and introduction of novel diagnostic and therapeutic immune strategies, to improve the survival of patients with leukemia, lymphoma and multiple myeloma.