I am a cardiovascular scientist and interventional cardiologist using biotechnological, molecular and cell biological methods as well as in vivo and ex vivo models to address translational research questions in the fields of inflammation, thrombosis and atherosclerosis. The aim of my research is to better understand the pathogenesis of cardiovascular disease and to develop new diagnostic and therapeutic strategies that ultimately provide direct benefits to patients.
I am a molecular biologist determining the mechanisms of eukaryotic mRNA translation and its regulation by RNA-binding proteins and noncoding RNA. In collaborative work I extend these basic science objectives into the medical research areas of cardiology
Receptor Tyrosine Kinase Function As Molecular Target In Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$415,788.00
Summary
As molecular cell biologist and protein chemist my motivation for research is to tackle metastatic cancer, one of the principle health burdens of the 21 century. Over the next five years I will lead R&D programs with national and international collaborators that will generate new diagnostic approaches and insights in basic and translational research. These will allow us to develop anti-cancer drugs, which target several of the mechanisms that are active in metastatic cancers.
I am a bioinformatician conducting methodological research in statistical functional genomics. I use designed experiments involving highthroughput gene expression technologies to make inferences about gene function and to make discoveries of medical signi